Demographic data of children TBE, adult severe TBE, and adult TBE cohorts.

<p>Demographic data of children TBE, adult severe TBE, and adult TBE cohorts.</p

Genotype distribution of <i>TLR3</i> rs3775291 and allele prevalence among TBE patients, Lithuanian TBEV-naive control subjects, and patients with aseptic meningoencephalitis (AME) of non-TBEV etiology.

<p>wt – wild type.</p>a<p> TBE1 vs C1+C2: p = 0.453 (Pearson's χ² test).</p>b<p> TBE2 vs C1+C2: p = 0.135 (Pearson's χ² test).</p>c<p> TBE1+TBE3 vs C1+C2: p = 0.02 (Pearson's χ² test).</p>d<p> TBE1+TBE2+TBE3 vs C1+C2: p = 0.025 (Pearson's χ² test).</p>e<p> TBE1+TBE3 vs C1+C2: OR = 1.449 (95% CI 1.085–1.936; p = 0.012).</p>f<p> TBE2 vs TBE3: p = 0.022 (Pearson's χ² test).</p>g<p> TBE2 vs TBE3: p = 0.009 (Pearson's χ² test).</p><p>Genotype distribution of <i>TLR3</i> rs3775291 and allele prevalence among TBE patients, Lithuanian TBEV-naive control subjects, and patients with aseptic meningoencephalitis (AME) of non-TBEV etiology.</p

Genotype distribution of <i>CCR5</i> and <i>Δ32</i> allele prevalence among patients with TBE, stratified by severity of disease.

<p>wt – wild type; M – Mild, Mo – Moderate, S – Severe form.</p><p><b>*</b> (wt/wt + wt/Δ32) vs Δ32/Δ32, M vs Mo vs S: p = 0.479; M vs (Mo+S): p = 0.292; wt vs Δ32, M vs Mo vs S: p = 0.571; M vs (Mo+S): p = 0.391.</p><p>** (wt/wt + wt/Δ32) vs Δ32/Δ32, M vs Mo vs S: p = 0.137; M vs (Mo+S): p = 0.202; wt vs Δ32, M vs Mo vs S: p = 0.806; M vs (Mo+S): p = 0.802.</p><p>Genotype distribution of <i>CCR5</i> and <i>Δ32</i> allele prevalence among patients with TBE, stratified by severity of disease.</p

Genotype distribution of <i>TLR3</i> rs3775291 and allele prevalence among patients with TBE, stratified by severity of disease.

<p>wt – wild type; M – Mild, Mo – Moderate, S – Severe form.</p><p>* wt/wt vs wt/mut vs mut/mut, M vs Mo vs S: p = 0.757; M vs (Mo+S): p = 0.485; wt vs mut, M vs Mo vs S: p = 0.476; M vs (Mo+S): p = 0.280.</p><p>** wt/wt vs wt/mut vs mut/mut, M vs Mo vs S: p = 0.264; M vs (Mo+S): p = 0.180; (wt/wt + wt/mut) vs mut/mut, M vs Mo vs S: p = 0.197; M vs (Mo+S): p = 0.071; wt vs mut, M vs Mo vs S: p = 0.157; M vs (Mo+S): p = 0.096.</p><p>Genotype distribution of <i>TLR3</i> rs3775291 and allele prevalence among patients with TBE, stratified by severity of disease.</p

CSF leukocyte and mononuclear cell count and total protein level in TBE patient cohorts, stratified by severity of disease.

<p>Note. Normal CSF cell count range: 0–5×10⁶/l leukocytes (all mononuclear cells), no red blood cells; normal total protein range: 0.15–0.45 g/l.</p><p>M – Mild, Mo – Moderate, S – Severe form.</p><p>* M vs Mo vs S, Leukocyte count: p = 0.114; Mononuclear cells: p = 0.160; Total protein: p = 0.362.</p><p>** M vs Mo vs S, Leukocyte count: p = 0.434; Mononuclear cells: p = 0.763; Total protein: p = 0.191.</p><p>*** M vs Mo vs S, Leukocyte count: p = 0.684; Mononuclear cells: p = 0.729; Total protein: p<0.001.</p><p>CSF leukocyte and mononuclear cell count and total protein level in TBE patient cohorts, stratified by severity of disease.</p