Force of infection modelling of seroconversion rates before and after MDA.

<p>A. Maximum likelihood fits from reversible catalytic equilibrium model for antibody responses either pgp3 or CT694 is shown. X-axis represents the time in years that each model has a change point. The y-axis is the log-likelihoods from each model where log-likelihoods are rescaled against a maximum of 0 and a log-likelihood above -2 is an approximate 95% confidence interval when the change occurred. B. A model in which SCR changed 10 years previously, to represent the time at which MDA ceased, had a better fit than the model that assumed the SCR had remained constant (likelihood ratio test X² = 45.4 p,0.0001). The triangles represent deciles of observed seroprevalence; the solid blue line represents the predicted values based on the model with dotted lines and the 95% CI.</p

Population structure of Kahe-Mpya and the study population.

<p>Population structure of Kahe-Mpya and the study population.</p

Antibody responses to <i>Ct</i> antigens 10 years after MDA cessation.

<p>A. Age-prevalence curves for antibody responses grouped by decade. Black squares represent individuals with any antibody-positive test (to pgp3 alone, CT694 alone, or both antigens), and red squares represent responses positive to both pgp3 and CT694. B. Plots show box-and-whiskers graph (min-max) of MFI-BG against age ranges grouped by decade for antibodies against pgp3 (left) and CT694 (right). C. Plots show age against MFI-BG for children aged 1–9. Each dot represents a single individual. Note the differences in the y-axis scales for pgp3 (left) and CT694 (right). Indeterminate range is shaded. Horizontal lines indicate cutoffs for antibody positivity. Ag = antigen.</p