1 research outputs found
Supplementary Material for: Autologous Stem Cell Transplantation in Multiple Myeloma in the Era of Novel Drug Induction: A Retrospective Single-Center Analysis
<p>Within this retrospective single-center study, we analyzed the
survival of 320 multiple myeloma (MM) patients receiving melphalan
high-dose chemotherapy (HDCT) and either single (<i>n</i> = 286) or tandem (<i>n</i>
= 34) autologous stem cell transplantation (ASCT) from 1996 to 2012.
Additionally, the impact of novel induction regimens was assessed.
Median follow-up was 67 months, median overall survival (OS) 62 months,
median progression-free survival (PFS) 33 months (95% CI 27-39), and
treatment-related death (TRD) 3%. Multivariate analysis revealed age ≥60
years (<i>p = </i>0.03) and stage 3 according to the International Staging System (<i>p = </i>0.006)
as adverse risk factors regarding PFS. Median OS was significantly
better in newly diagnosed MM patients receiving induction therapy with
novel agents, e.g., bortezomib, thalidomide, or lenalidomide, compared
with a traditional regimen (69 vs. 58 months; <i>p = </i>0.01). More
patients achieved at least a very good partial remission in the period
from 2005 to 2012 than from 1996 to 2004 (65 vs. 30%; <i>p</i> < 0.001), with a longer median OS in the later period (71 vs. 52 months, <i>p</i>
= 0.027). In conclusion, our analysis confirms HDCT-ASCT as an
effective therapeutic strategy in an unselected large myeloma patient
cohort with a low TRD rate and improved prognosis due to novel induction
strategies.</p