Folic acid supplementation on global DNA methylation for the whole study population, for those with less than normal RBC folate status at baseline, low and high baseline methylation, and stratified by MTHFR C677T genotype.

1<p>values are given as median (inter-quartile range).</p>2<p>global DNA methylation is expressed as a percentage of 5-methylcytosines versus the total number of cytosines present in the genome.</p

Baseline characteristics of the population.

<p>Baseline characteristics of the population.</p

Overview of all randomized controlled trials of folic acid with global DNA methylation as an endpoint.

1<p>conversion factor of 2.266 for folate from ng/mL to nmol/L.</p

General characteristics of the mismatch repair gene mutation carriers in the GEOLynch prospective cohort study.

<p>a College or university degree</p><p>b Highest tertile of the physical activity score</p><p>c CRC =  colorectal cancer</p><p>d History of colorectal adenoma and/or carcinoma</p><p>e Use of any dietary supplement during the last month</p><p>f E.g. glucosamine/chondroitin supplements, and garlic pills</p

Association of any dietary supplement use and colorectal adenoma risk stratified for smoking status and total fruit and vegetables intake in the GEOLynch prospective cohort study of MMR gene mutation carriers.

<p>a No use of dietary supplements during the last month</p><p>b Use of any dietary supplement during the last month</p

General characteristics of the mismatch repair gene mutation carriers stratified by dietary supplement use in the GEOLynch prospective cohort study.

<p>a Use of any dietary supplement during the last month</p><p>b No use of dietary supplement during the last month</p><p>c College or university degree</p><p>d Highest tertile of the physical activity score <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066819#pone.0066819-Pols1" target="_blank">[31]</a></p><p>e CRC =  colorectal cancer</p><p>f History of colorectal adenoma and/or carcinoma</p><p>g E.g. glucosamine/chondroitin supplements, and garlic pills</p><p>h Calculated using Mann-Whitney U test for continuous variables or the χ2 test for categorical variables</p

Association of dietary supplement use and colorectal adenoma risk in the GEOLynch prospective cohort study of MMR gene mutation carriers.

<p>a No use of dietary supplements during the last month</p><p>b Use of any dietary supplement during the last month</p

Association of rs2256787 in the <i>ARHGEF10L</i> gene with invasive endometrioid EOC risk by study site and combined.

<p>Squares represent the estimated per-allele odds ratio (OR) and are proportional to sample size for each study; lines indicate its 95% confidence interval (CI); source indicates contributing study;[<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0197561#pone.0197561.ref011" target="_blank">11</a>] MAF, control minor allele frequency; PVal, per-allele p-value adjusted for age, site, and principal components to account for residual differences in European ancestry.</p

Association of variants in small GTPase genes with epithelial ovarian cancer risk (p-value<10⁻⁴) and functional annotation.

<p>Association of variants in small GTPase genes with epithelial ovarian cancer risk (p-value<10⁻⁴) and functional annotation.</p