An automated motion detection and reward system for animal training

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A Review of Academic Literature on Internal Control Reporting Under SOX

Section 404 of the Sarbanes-Oxley Act of 2002 (SOX) mandates reporting on the effectiveness of internal control over financial reporting (ICFR) by public company management and auditors. Such reporting began for fiscal years ended Nov 15, 2004 for accelerated filers and is scheduled to be fully implemented for non-accelerated filers in mid-2010. Section 404(a) of SOX requires public company management to include an assessment of the effectiveness of the company\u27s ICFR in its annual internal control report, and Section 404(b) requires attestation by the company\u27s auditor. The authors review the literature on internal control reporting under both Sections 302 and 404 in the post-SOX period. The internal control literature has grown substantially since the passage of SOX due to the availability of data regarding ICFR effectiveness that were not previously available. They conducted a literature search through mid-2009 resulting in the inclusion of many published papers and working papers that address ICFR issues covered in our taxonomy

Conflict, Value Diversity, and Performance in Virtual Teams

While most studies investigating culture in the context of conflict in teams have been using culture dimensions such as collectivism this study centers on another measurement of culture, namely individual values. In this investigation we examined how individual value diversity influences the relationship between team conflict and performance in virtual teams. Assessing two types of conflict, namely task and process conflict, the results revealed that task conflict had no unique effect beyond the impact of process conflict. Contrary to previous findings relating to group culture, this study found that value diversity has no influence on the relationship between conflict and performance in virtual teams. While individuals come to groups with their own values, they may be less powerful predictors of their behavior in groups where there are strong prevailing group values and norms to act a certain way

A Multi-Level View of the Antecedents and Consequences of Trust in Virtual Leaders

Although trust is widely acknowledged as critical to virtual teams, little is known regarding the causes and consequences of trust in leaders of virtual teams. This paper examines the antecedents and consequences of trust in virtual team leaders. Using survey and archival data from a massively multiplayer online game (MMOG), this study’s findings show that trust in the leader is affected by team members’ use of synchronous communication and breadth of communication with leaders as well as team members’ distance from each other. Furthermore, reasoning that team size and culture create a shared context qualifying team members’ experiences, we found that team size and collectivistic values diminished the benefits of synchronous communication and breadth of communication, respectively. The findings also revealed that trust in leaders had a positive relationship to team performance. Detailed discussion of the findings is provided in the conclusion of the paper

TASEP modelling provides a parsimonious explanation for the ability of a single uORF to derepress translation during the integrated stress response

Translation initiation is the rate-limiting step of protein synthesis that is downregulated during the Integrated Stress Response (ISR). Previously, we demonstrated that most human mRNAs that are resistant to this inhibition possess translated upstream open reading frames (uORFs), and that in some cases a single uORF is sufficient for the resistance. Here we developed a computational model of Initiation Complexes Interference with Elongating Ribosomes (ICIER) to gain insight into the mechanism. We explored the relationship between the flux of scanning ribosomes upstream and downstream of a single uORF depending on uORF features. Paradoxically, our analysis predicts that reducing ribosome flux upstream of certain uORFs increases initiation downstream. The model supports the derepression of downstream translation as a general mechanism of uORF-mediated stress resistance. It predicts that stress resistance can be achieved with long slowly decoded uORFs that do not favor translation reinitiation and that start with initiators of low leakiness

Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy

Sigmatropic rearrangements, while rare in biology, offer opportunities for the efficient and selective synthesis of complex chemical motifs. A “P411” serine-ligated variant of cytochrome P450_(BM3) has been engineered to initiate a sulfimidation/[2,3]-sigmatropic rearrangement sequence in whole E. coli cells, a non-natural function for any enzyme, providing access to enantioenriched, protected allylic amines. Five mutations in the enzyme substantially enhance its activity toward this new function, demonstrating the evolvability of the catalyst toward challenging nitrene transfer reactions. The evolved catalyst additionally performs the highly enantioselective imidation of non-allylic sulfides

The WMO SPICE snow-on-ground intercomparison: an overview of sensor assessment and recommendations on best practices

Comunicación presentada en: TECO-2016 (Technical Conference on Meteorological and Environmental Instruments and Methods of Observation) celebrada en Madrid, del 27 al 30 de septiembre de 2016.One of the objectives of the WMO Solid Precipitation Intercomparison Experiment (SPICE) was to assess the performance and capabilities of automated sensors for measuring snow on the ground (SoG), including sensors that measure snow depth and snow water equivalent (SWE). The intercomparison focused on five snow depth sensors (models SHM30, SL300, SR50A, FLS-CH 10 and USH-8) and two SWE sensors (models CS725 and SSG1000) over two winter seasons (2013/2014 and 2014/2015). A brief discussion of the measurement reference(s) and an example of the intercomparisons are included. Generally, each of the sensors under test operated according to the manufacturer’s specifications and compared well with the site references, exhibiting high correlations with both the manual and automated reference measurements. The use of natural and artificial surface targets under snow depth sensors were examined in the context of providing a stable and representative surface for snow depth measurements. An assessment of sensor derived measurement quality and sensor return signal strength, where available as an output option, were analysed to help explain measurement outliers and sources of uncertainty with the goal of improving data quality and maximizing the sensor capabilities. Finally, where possible, relationships are established between the gauge measurement of solid precipitation and the measurement of snow on the ground. This paper will provide a brief summary of these results with more detail included in the WMO SPICE Final Report

The key glycolytic enzyme phosphofructokinase is involved in resistance to antiplasmodial glycosides

ABSTRACT Plasmodium parasites rely heavily on glycolysis for ATP production and for precursors for essential anabolic pathways, such as the methylerythritol phosphate (MEP) pathway. Here, we show that mutations in the Plasmodium falciparum glycolytic enzyme, phosphofructokinase (PfPFK9), are associated with in vitro resistance to a primary sulfonamide glycoside (PS-3). Flux through the upper glycolysis pathway was significantly reduced in PS-3-resistant parasites, which was associated with reduced ATP levels but increased flux into the pentose phosphate pathway. PS-3 may directly or indirectly target enzymes in these pathways, as PS-3-treated parasites had elevated levels of glycolytic and tricarboxylic acid (TCA) cycle intermediates. PS-3 resistance also led to reduced MEP pathway intermediates, and PS-3-resistant parasites were hypersensitive to the MEP pathway inhibitor, fosmidomycin. Overall, this study suggests that PS-3 disrupts core pathways in central carbon metabolism, which is compensated for by mutations in PfPFK9, highlighting a novel metabolic drug resistance mechanism in P. falciparum. IMPORTANCE Malaria, caused by Plasmodium parasites, continues to be a devastating global health issue, causing 405,000 deaths and 228 million cases in 2018. Understanding key metabolic processes in malaria parasites is critical to the development of new drugs to combat this major infectious disease. The Plasmodium glycolytic pathway is essential to the malaria parasite, providing energy for growth and replication and supplying important biomolecules for other essential Plasmodium anabolic pathways. Despite this overreliance on glycolysis, no current drugs target glycolysis, and there is a paucity of information on critical glycolysis targets. Our work addresses this unmet need, providing new mechanistic insights into this key pathway

The epidemiology of injury and illness at the Vitality Netball World Cup 2019 : an observational study

BACKGROUND : Netball is a physical game with sudden direction changes, decelerations, jumping and landing, stop/start maneuvers and restrictive footwork rules exposing players to injury. Close contact play and shared facilities during tournaments, increase illness risk. OBJECTIVE : To describe incidence, period prevalence, types and severity of injuries and illnesses during the 10-day Vitality Netball World Cup 2019 (NWC). METHODS : All players from 16 teams consented (n = 192). Medical staff recorded injuries (840 exposure hours), illnesses (1440 player-days) and time-loss. Main outcome measures included incidence (I) calculated as injury/1000 player-hours and illness/1000 player-days, period prevalence (PP) and severity (time-loss) of all match injuries and illnesses. RESULTS : 39 players sustained 46 match injuries (I = 54.76; PP = 20.31%). Lower limb injuries (I = 29.76), specifically the ankle (I = 13.10) were most common with lateral ankle ligament sprains the highest (I = 17.39). Contact injuries (I = 40.48) significantly exceeded non-contact injuries (I = 14.29; p = 0.0124). Center players sustained most injuries (n = 12; 26%; I = 14.29), followed by goalkeepers (n = 10; 22%; I = 11.90) and goal defenders (n = 8; 17%; I = 9.52). Injuries occurred in almost 50% of matches, and 67% did not result in time-loss. Time-loss injuries (n = 14; 33%) were most frequent in the lower limb (n = 10; 71%) specifically involved lateral ankle ligaments (n = 4; 29%), attributable to contact (n = 11; 79%) and mostly implicated center players and goal defenders (n = 4 each; 29% each). 11 players contracted 11 illnesses (I = 7.64; PP = 5.72%) with respiratory tract illness contributing 36%. Most illnesses did not result in time-loss (91%). CONCLUSION : This is the first study reporting injury and illness during an NWC. Contact was the main mechanism of injury, and 2/3 of injuries did not result in time-loss. The ankle is most commonly injured and center players sustain most injuries. Non-respiratory system disease was most frequent, but upper respiratory tract infection remains the most common diagnosis. Targeted surveillance studies using similar methodology are required to develop injury and illness preventative strategies in elite netball.https://tandfonline.com/toc/ipsm202022-06-07hj2021Sports MedicineStatistic

Analysis of adequacy levels for human resources improvement within primary health care framework in Africa

Human resources in health care system in sub-Saharan Africa are generally picturing a lack of adequacy between expected skills from the professionals and health care needs expressed by the populations. It is, however, possible to analyse these various lacks of adequacy related to human resource management and their determinants to enhance the effectiveness of the health care system. From two projects focused on nurse professionals within the health care system in Central Africa, we present an analytic grid for adequacy levels looking into the following aspects: - adequacy between skills-based profiles for health system professionals, quality of care and service delivery (health care system /medical standards), needs and expectations from the populations, - adequacy between allocation of health system professionals, quality of care and services delivered (health care system /medical standards), needs and expectations from the populations, - adequacy between human resource management within health care system and medical standards, - adequacy between human resource management within education/teaching/training and needs from health care system and education sectors, - adequacy between basic and on-going education and realities of tasks expected and implemented by different categories of professionals within the health care system body, - adequacy between intentions for initial and on-going trainings and teaching programs in health sciences for trainers (teachers/supervisors/health care system professionals/ directors (teaching managers) of schools...). This tool is necessary for decision-makers as well as for health care system professionals who share common objectives for changes at each level of intervention within the health system. Setting this adequacy implies interdisciplinary and participative approaches for concerned actors in order to provide an overall vision of a more broaden system than health district, small island with self-rationality, and in which they operate