2 research outputs found
The Enterics for Global Health (EFGH) Shigella Surveillance Study in Kenya
Background: Although Shigella is an important cause of diarrhea in Kenyan children, robust research platforms capable of conducting incidence-based Shigella estimates and eventual Shigella-targeted clinical trials are needed to improve Shigella-related outcomes in children. Here, we describe characteristics of a disease surveillance platform whose goal is to support incidence and consequences of Shigella diarrhea as part of multicounty surveillance aimed at preparing sites and assembling expertise for future Shigella vaccine trials.
Methods: We mobilized our preexisting expertise in shigellosis, vaccinology, and diarrheal disease epidemiology, which we combined with our experience conducting population-based sampling, clinical trials with high (97%–98%) retention rates, and healthcare utilization surveys. We leveraged our established demographic surveillance system (DSS), our network of healthcare centers serving the DSS, and our laboratory facilities with staff experienced in performing microbiologic and molecular diagnostics to identify enteric infections. We joined these resources with an international network of sites with similar capabilities and infrastructure to form a cohesive scientific network, designated Enterics for Global Health (EFGH), with the aim of expanding and updating our knowledge of the epidemiology and adverse consequences of shigellosis and enriching local research and career development priorities.
Conclusions: Shigella surveillance data from this platform could help inform Shigella vaccine trials
Effect of cigarette smoke on body weight, food intake and reproductive organs in adult albino rats
562-565One hour daily exposure to cigarette smoke for
two months significantly decreased the body weight and food intake in male and
female albino rats. The latency for conception increased significantly and the
litter size decreased. Mortality rate per litter increased and grayish
discoloration of the skin in the experimental group was the only congenital
anomaly seen. Testes and ovaries showed a significant decrease in weight. The
stroma of the ovaries were occupied by very few Graafian follicles. Testes
showed disruption of the normal orderly progression of the spermatogonia. The
tubules showed only one layer of spermatogonia and very few germinal cells. The
number of sperms was less in the testes. The results show that exposure to
cigarette smoke is detrimental to the reproductivity in both, male and female
albino rats