A micro vertical axis wind turbine (vawt) tested in the Jules Verne wind tunnel

International audienc

A micro vertical axis wind turbine (vawt) tested in the Jules Verne wind tunnel

International audienc

Contribution to Power Maximization of an Asynchronous Wind Electric Water Pumping System Using Single Input Fuzzy Logic Controller & Modified Enhanced Perturb and Observe

This paper investigates the efficiency of an original approach for Maximum Power Point Tracking (MPPT) algorithm applied to a Wind Electric Water Pumping System (WEWPS). The studied model is developed under Matlab/Sim-ulink software and consists of an asynchronous wind turbine, a Static Var Com-pensator (SVC) and a centrifugal water pump driven by a three phase Induction Motor (IM). The proposed control technique seeks to improve water flow rate by exploring the maximum amount of electrical power produced by the asynchro-nous wind turbine in a wide range of wind speed. Theoretical analysis as well as simulation results have shown that the highest electrical power rate depends on the value of the produced voltage which can be controlled by the SVC using single input fuzzy logic regulator. Modified Enhanced Perturb and Observe (MEPO) algorithm is then used in this application to calculate the optimal value of the voltage reference that ensure maximum electric power extraction and hence maximal water flow rate. Moreover, a comparison have been made with the conventional P&O algorithm to prove the superior performance of the proposed approach which does neither require to measure wind speed nor to know the WEWPS parameters

Influence of genetic factors on long-term treatment related neurocognitive complications, and on anxiety and depression in survivors of childhood acute lymphoblastic leukemia: The Petale study.

BackgroundA substantial number of survivors of childhood acute lymphoblastic leukemia suffer from treatment-related late adverse effects including neurocognitive impairment. While multiple studies have described neurocognitive outcomes in childhood acute lymphoblastic leukemia (ALL) survivors, relatively few have investigated their association with individual genetic constitution.MethodsTo further address this issue, genetic variants located in 99 genes relevant to the effects of anticancer drugs and in 360 genes implicated in nervous system function and predicted to affect protein function, were pooled from whole exome sequencing data of childhood ALL survivors (PETALE cohort) and analyzed for an association with neurocognitive complications, as well as with anxiety and depression. Variants that sustained correction for multiple testing were genotyped in entire cohort (n = 236) and analyzed with same outcomes.ResultsCommon variants in MTR, PPARA, ABCC3, CALML5, CACNB2 and PCDHB10 genes were associated with deficits in neurocognitive tests performance, whereas a variant in SLCO1B1 and EPHA5 genes was associated with anxiety and depression. Majority of associations were modulated by intensity of treatment. Associated variants were further analyzed in an independent SJLIFE cohort of 545 ALL survivors. Two variants, rs1805087 in methionine synthase, MTR and rs58225473 in voltage-dependent calcium channel protein encoding gene, CACNB2 are of particular interest, since associations of borderline significance were found in replication cohort and remain significant in combined discovery and replication groups (OR = 1.5, 95% CI, 1-2.3; p = 0.04 and; OR = 3.7, 95% CI, 1.25-11; p = 0.01, respectively). Variant rs4149056 in SLCO1B1 gene also deserves further attention since previously shown to affect methotrexate clearance and short-term toxicity in ALL patients.ConclusionsCurrent findings can help understanding of the influence of genetic component on long-term neurocognitive impairment. Further studies are needed to confirm whether identified variants may be useful in identifying survivors at increased risk of these complications