Cutaneous metastasis from colorectal cancer: Making light on an unusual and misdiagnosed event

Cutaneous metastasis from solid tumors is a rare event and usually represents a late occurrence in the natural history of an advanced visceral malignancy. Rarely, cutaneous metastasis has been described in colorectal cancer patients. The most frequent cutaneous site of colorectal metastasis is the surgical scar in the abdomen following the removal of the primary malignancy, followed by the extremities, perineum, head, neck, and penis. Metastases to the thigh and back of the trunk are anecdotical. Dermatological diagnosis of cutaneous metastasis can be quite complex, especially in unusual sites, such as in the facial skin or thorax and in cases of single cutaneous lesions since metastasis from colorectal cancer is not usually the first clinical hypothesis, leading to misdiagnosis. To date, due to the rarity of cutaneous metastasis from colorectal cancer, little evidence, most of which is based on case reports and very small case series, is currently available. Therefore, a better understanding of the clinic-pathological characteristics of this unusual metastatic site represents an unmet clinical need. We present a large series of 29 cutaneous metastases from colorectal cancer with particular concerns regarding anatomic localization and the time of onset with respect to primitive colorectal cancer and visceral metastases

Lipid lesion distribution in right coronary artery of young people of different countries (PBDAY-WHO-ISFC Study)

Natural history of Atherosclerosis. Results of the International Work on natural history of Atherosclerosis, PBDAY of the World Health Organization, using probability-of-occurrence maps on right coronary arteries in youth from people lived in many Countries of the worl

Preliminary morphometric data on lipid lesion distribution in aortas of young people (WHO-ISFC PBDAY study)

Natural history of Atherosclerosis. Results of the International Work on natural history of Atherosclerosis, PBDAY of the World Health Organization, using probability-of-occurrence maps on lipd lesions of abdominal and thoracic Aortas in youth from people that lived in many Countries of the world

First morphometric data on lipid and raised lesion distribution in aortas of young people of different geographical origin (WHO-ISFC PBDAY Study)

Natural history of Atherosclerosis. Results of the International Work on natural history of Atherosclerosis, PBDAY of the World Health Organization, using probability-of-occurrence maps on abdominal and thoracic Aortas in youth from people lived in many Countries of the worl

Distribution of lipid and raised lesions in aortas of young people of different geographic origins (WHO-ISFC PBDAY study)

At the Morphometric Reference Center of the World Health Organization-International Society and Federation of Cardiology PBDAY (Pathobiological Determinants of Atherosclerosis in Youth) project, we studied left hemiaortas of 5- through 34-year-old male and female healthy subjects who died of traumatic injury. The subjects were either of European, American, Asian, or African origin. Three hundred fifty-five thoracic and 343 abdominal left hemiaortas, stained and photographed at the Malmö, Sweden, World Health Organization Reference Center, were studied. Lipid and raised lesion extent was evaluated by using computerized techniques. Probability-of-occurrence maps of lipid and raised lesion distribution were obtained by image processing. Our data have shown that the distributions of atherosclerotic lesions in the aortic intimal surface, which were similar in the different ethnic groups, also prevailed in branching regions, where low-blood flow shear stress and turbulence occur. The areas involved by raised lesions and by lipid lesions only partially overlapped. Lipid lesion extent, which was different among the ethnic groups, continuously increased with age in males but not in females, in whom the increase ceased at an age range from 15 through 24 years. This suggests that ethnic and dietary factors influence the extent but not the distribution of atherosclerotic lesions in the human aorta. Probability-of-occurrence maps also provided evidence that not every fatty streak will develop into a raised lesion, or will not develop quickly