377 research outputs found
Report on the Fifth Annual Meeting of the Association for Immunotherapy of Cancer (CIMT) April 12–14, 2007 in Würzburg, Germany
On Lattice QCD with Many Flavors
We discuss the confining and chiral-symmetry breaking properties of QCD with
a large number of flavors . In a Monte Carlo simulation of QCD with staggered fermions, we find clear evidence of a first order bulk phase
transition which separates phases with broken and unbroken chiral symmetry.
This is consistent with extrapolations of earlier studies with smaller ,
and is also as expected from general arguments. Thus, even when the
perturbative renormalization group flow has a new infrared stable fixed point
near the origin, lattice artifacts induce chiral symmetry breaking, and
presumably confinement, at sufficiently strong coupling.Comment: 10 pages, LaTeX, figures part of the LaTeX fil
Asymptotic Behavior of the Correlator for Polyakov Loops
The asymptotic behavior of the correlator for Polyakov loop operators
separated by a large distance is determined for high temperature QCD. It is
dominated by nonperturbative effects related to the exchange of magnetostatic
gluons. To analyze the asymptotic behavior, the problem is formulated in terms
of the effective field theory of QCD in 3 space dimensions. The Polyakov loop
operator is expanded in terms of local gauge-invariant operators constructed
out of the magnetostatic gauge field, with coefficients that can be calculated
using resummed perturbation theory. The asymptotic behavior of the correlator
is , where is the mass of the lowest-lying glueball in
-dimensional QCD. This result implies that existing lattice calculations
of the Polyakov loop correlator at the highest temperatures available do not
probe the true asymptotic region in .Comment: 10 pages, NUHEP-TH-94-2
The transcriptional landscape of endogenous retroelements delineates esophageal adenocarcinoma subtypes
Most cancer types exhibit aberrant transcriptional activity, including derepression of retrotransposable elements (RTEs). However, the degree, specificity and potential consequences of RTE transcriptional activation may differ substantially among cancer types and subtypes. Representing one extreme of the spectrum, we characterize the transcriptional activity of RTEs in cohorts of esophageal adenocarcinoma (EAC) and its precursor Barrett's esophagus (BE) from the OCCAMS (Oesophageal Cancer Clinical and Molecular Stratification) consortium, and from TCGA (The Cancer Genome Atlas). We found exceptionally high RTE inclusion in the EAC transcriptome, driven primarily by transcription of genes incorporating intronic or adjacent RTEs, rather than by autonomous RTE transcription. Nevertheless, numerous chimeric transcripts straddling RTEs and genes, and transcripts from stand-alone RTEs, particularly KLF5- and SOX9-controlled HERVH proviruses, were overexpressed specifically in EAC. Notably, incomplete mRNA splicing and EAC-characteristic intronic RTE inclusion was mirrored by relative loss of the respective fully-spliced, functional mRNA isoforms, consistent with compromised cellular fitness. Defective RNA splicing was linked with strong transcriptional activation of a HERVH provirus on Chr Xp22.32 and defined EAC subtypes with distinct molecular features and prognosis. Our study defines distinguishable RTE transcriptional profiles of EAC, reflecting distinct underlying processes and prognosis, thus providing a framework for targeted studies
Heavy Quark Free Energies and Screening in SU(2) Gauge Theory
We investigate the singlet, triplet and colour average heavy quark free
energies in SU(2) pure gauge theory at various temperatures T. We focus on the
long distance behaviour of the free energies, studying in particular the
temperature dependence of the string tension and the screening masses. The
results are qualitatively similar to the SU(3) scenario, except near the
critical temperature Tc of the deconfining transition. Finally we test a
recently proposed method to renormalize the Polyakov loop.Comment: 5 pages, 4 figures, contribution to the Proceedings of SEWM 2002
(Heidelberg
Recommended from our members
Pollution control and environmental monitoring efforts at DOE's Coal-Fired Flow Facility
Proof-of-Concept (POC) scale demonstration of such technology is currently being carried out at the US Department of Energy's (DOE's) Coal-Fired Flow Facility (CFFF), located at The University of Tennessee Space Institute (UTSI) in Tullahoma, Tennessee and at the Component Development and Integration Facility in Butte, Montana. The CFFF is dedicated to the evaluation of downstream (steam cycle) components and technology that may be considered for a full-scale MHD system. The objectives of the CFFF testing include the demonstration of various pollution control devices and techniques at a scale sufficient for future scale-up. The CFFF offers a unique test environment in which emissions control techniques can be developed and evaluated through emissions and environmental monitoring. Results thus far have demonstrated the ability of sulfur oxide (SO{sub x}), nitrogen oxide (NO{sub x}) and particulate emissions well below the New Source Performance Standards (NSPS). Regeneration of the potassium sulfate to produce sulfur-free compounds also has been demonstrated. The experimental program at the CFFF is now aimed at determining the optimum conditions for future commercial scale designs. Because of increased interests in Air Toxics, measurements of nitrous oxide (N{sub 2}O), a potential greenhouse gas, priority pollutants (inorganic as well as organics), and chlorine-containing species (Cl{sub 2} and HCl) are also included in our ongoing efforts. Environmental monitoring activities are being pursued to develop an environmental impact assessment data base. These include the use of three ambient air sites to determine the impacts of gaseous and particulate emissions, five lake water sites to determine impacts due to process water discharges and seven sites to collect terrestrial data on possible soil contamination and tree growth. In this paper, we will summarize the status of our ongoing environmental program. 16 refs., 15 figs., 3 tabs
Quasimolecular =3/2 moments in the cluster Mott insulator GaTaSe
Quasimolecular orbitals in cluster Mott insulators provide a route to tailor
exchange interactions, which may yield novel quantum phases of matter. We
demonstrate the cluster Mott character of the lacunar spinel GaTaSe
using resonant inelastic x-ray scattering (RIXS) at the Ta edge.
Electrons are fully delocalized over Ta tetrahedra, forming quasimolecular
=3/2 moments. The modulation of the RIXS intensity as function of
the transferred momentum q allows us to determine the cluster wavefunction,
which depends on competing intracluster hopping terms that mix states with
different character. This mixed wavefunction is decisive for the macroscopic
properties since it affects intercluster hopping and exchange interactions and
furthermore renormalizes the effective spin-orbit coupling constant. The
versatile wavefunction, tunable via intracluster hopping, opens a new
perspective on the large family of lacunar spinels and cluster Mott insulators
in general.Comment: 7 pages, 4 figures, plus supplementary informatio
Quarkonium Suppression
I discuss quarkonium suppression in equilibriated strongly interacting
matter. After a brief review of basic features of quarkonium production I
discuss the application of recent lattice data on the heavy quark potential to
the problem of quarkonium dissociation as well as the problem of direct lattice
determination of quarkonium properties in finite temperature lattice QCD.Comment: Invited plenary talk presented on 4th International Conference on
Physics and Astrophysics of Quark Gluon Plasma (ICPAQGP-2001), November
26-30, 2001, Jaipur; 12 pp, LaTeX, uses pramana.st
- …