Re-colonizing spaces of memorializing: the case of the Chattri Indian Memorial, UK

This article inspects the ways that spaces of war memorialization are organized and reorganized through official and unofficial meaning-making activities. It aims to contribute to the discussion of the ‘value’ of memorializing by examining a multifaceted space of remembrance and commemoration: the Chattri Indian Memorial built near Brighton, UK. The article brings postcolonial perspectives to explore how memorializing has been organized here, focusing on the activities of once-colonized people and the affective, embodied aspects of organizing practices. Built in 1921 to honour Indian soldiers who fought in WWI, the Chattri evolved from a colonial instrument to symbol and space for ethnic-Indian group activities. The study employed historical, visual and ethnographic methods to study the tangible monument and the changing nature of the memorializing activities carried out around the monument. Memorializing is conceptualized within three inter-related processes: colonizing, de-colonizing and re-colonizing to examine how forms and practices of memorialization constitute a values-laden organizing system

Distribution of propensity scores of the IHC CRC dataset with a 2-to-1 matching arrangement.

Distribution of propensity scores of the IHC CRC dataset with a 2-to-1 matching arrangement.</p

Human participants research checklist.

BackgroundAnalysis of omics data that contain multidimensional biological and clinical information can be complex and make it difficult to deduce significance of specific biomarker factors.MethodsWe explored the utility of propensity score matching (PSM), a statistical technique for minimizing confounding factors and simplifying the examination of specific factors. We tested two datasets generated from cohorts of colorectal cancer (CRC) patients, one comprised of immunohistochemical analysis of 12 protein markers in 544 CRC tissues and another consisting of RNA-seq profiles of 163 CRC cases. We examined the efficiency of PSM by comparing pre- and post-PSM analytical results.ResultsUnlike conventional analysis which typically compares randomized cohorts of cancer and normal tissues, PSM enabled direct comparison between patient characteristics uncovering new prognostic biomarkers. By creating optimally matched groups to minimize confounding effects, our study demonstrates that PSM enables robust extraction of significant biomarkers while requiring fewer cancer cases and smaller overall patient cohorts.ConclusionPSM may emerge as an efficient and cost-effective strategy for multiomic data analysis and clinical trial design for biomarker discovery.</div

Comparison of IHC scoring between good and poor prognosis groups after 2-to-1 PSM.

Comparison of IHC scoring between good and poor prognosis groups after 2-to-1 PSM.</p

Random forest rankings of prognostic factors in the CRC proteomic marker dataset.

(A) Ranking of variable importance (VIMP). The blue bars represent positive values of VIMP, indicating that the corresponding factor is positively associated with prognostic prediction. While the red bars represent negative values of VIMP, indicating that the factor is negatively associated with prognostic prediction. (B) Ranking of minimal depth. The small minimal depth indicates that the factor plays an important role in prognostic prediction. The vertical dashed line indicates the minimal depth threshold where smaller minimal depth values indicate higher importance and larger indicate lower importance as calculated by the “gg_minimal_depth” function of the “ggRandomForests” R package (version 4.7–1.1). (C) The combination of variable importance (VIMP) and minimal depth. The blue dots represent positive values of VIMP, while red dots represent negative values of VIMP. The threshold represented by the vertical red dashed line indicates VIMP = 0. The threshold represented by the horizontal red dashed line is equal to (B).</p

Distribution of propensity scores of the IHC CRC dataset.

Distribution of propensity scores of the IHC CRC dataset.</p

Comparison of protein marker expression between groups before and after PSM.

Comparison of protein marker expression between groups before and after PSM.</p

Genes commonly selected before and after PSM.

BackgroundAnalysis of omics data that contain multidimensional biological and clinical information can be complex and make it difficult to deduce significance of specific biomarker factors.MethodsWe explored the utility of propensity score matching (PSM), a statistical technique for minimizing confounding factors and simplifying the examination of specific factors. We tested two datasets generated from cohorts of colorectal cancer (CRC) patients, one comprised of immunohistochemical analysis of 12 protein markers in 544 CRC tissues and another consisting of RNA-seq profiles of 163 CRC cases. We examined the efficiency of PSM by comparing pre- and post-PSM analytical results.ResultsUnlike conventional analysis which typically compares randomized cohorts of cancer and normal tissues, PSM enabled direct comparison between patient characteristics uncovering new prognostic biomarkers. By creating optimally matched groups to minimize confounding effects, our study demonstrates that PSM enables robust extraction of significant biomarkers while requiring fewer cancer cases and smaller overall patient cohorts.ConclusionPSM may emerge as an efficient and cost-effective strategy for multiomic data analysis and clinical trial design for biomarker discovery.</div

Fig 5 -

(A–B) RNA–seq volcano plot comparing good prognosis group vs. poor prognosis group. Green dots (N = 93) represent genes that are significant in both pre–and post–PSM comparison between the good–and poor–prognosis groups. Blue dots (N = 217) represent genes that are significant only in the pre–PSM comparison between the good–and poor–prognosis groups. Red dots (N = 29) represent genes that are significant only in the post–PSM comparison between the good–and poor–prognosis groups. Grey dots (N = 12,121) represent genes that did not show significant differences. (C) The Venn diagram of significant genes before and after PSM. The blue circle represents before PSM, and the yellow represents after PSM.</p

Genes significantly associated with CRC prognosis uncovered only by PSM.

Genes significantly associated with CRC prognosis uncovered only by PSM.</p