Retrieve-and-Read: Multi-task Learning of Information Retrieval and Reading Comprehension

This study considers the task of machine reading at scale (MRS) wherein, given a question, a system first performs the information retrieval (IR) task of finding relevant passages in a knowledge source and then carries out the reading comprehension (RC) task of extracting an answer span from the passages. Previous MRS studies, in which the IR component was trained without considering answer spans, struggled to accurately find a small number of relevant passages from a large set of passages. In this paper, we propose a simple and effective approach that incorporates the IR and RC tasks by using supervised multi-task learning in order that the IR component can be trained by considering answer spans. Experimental results on the standard benchmark, answering SQuAD questions using the full Wikipedia as the knowledge source, showed that our model achieved state-of-the-art performance. Moreover, we thoroughly evaluated the individual contributions of our model components with our new Japanese dataset and SQuAD. The results showed significant improvements in the IR task and provided a new perspective on IR for RC: it is effective to teach which part of the passage answers the question rather than to give only a relevance score to the whole passage.Comment: 10 pages, 6 figure. Accepted as a full paper at CIKM 201

Introduction of Experimental Animal Center, Joint Faculty of Veterinary Medicine, Kagoshima University

To improve the quality of education and research with laboratory animals, Experimental Animal Center (EAC) was established as an animal facility in the Joint Faculty of Veterinary Medicine, Kagoshima University, on September 1st, 2015. We can house and use large-sized (bovine and horse), medium-sized (dog, cat, pig and bird), and small-sized (rodent and rabbit) animals in this facility. Our care and use program of laboratory animals in EAC was fully accredited by AAALAC International on June 9th, 2016. We are using this facility to demonstrate to our students that performance of veterinary care and animal welfare is important for appropriate education and scientific research with laboratory animals in Veterinary Medicine

The Role of Public Broadcasting in Media Bias:Do People React Differently to Pro-government Bias in Public and Private Media?

People often reject new information, especially when it does not fit their prior beliefs. But do publics in advanced democracies reject information from public and private media outlets in the same way? We examine this question in the form of the media’s pro-government bias in the under-examined case of Japan. By combining unique textual data with an original survey experiment, we document that (1) people generally tend to reject pro-government biased information that overly praises government actions; but (2) the reasons why people reject the same biased information vary—based on their expectations of neutrality for public media, and on expectations derived from political ideology for private media. Our study suggests that the basis of people’s motivated reasoning differs when they evaluate content from public and private media

More Efficient Adaptively Secure Lattice-based IBE with Equality Test in the Standard Model

Identity-based encryption with equality test (IBEET) is a variant of identity-based encryption (IBE), where any users who have trapdoors can check whether two ciphertexts are encryption of the same plaintext. Although several lattice-based IBEET schemes have been proposed, they have drawbacks in either security or efficiency. Specifically, most schemes satisfy only selective security, while adaptively secure schemes in the standard model suffer from large master public keys that consist of linear numbers of matrices. In other words, known lattice-based IBEET schemes perform poorly compared to the state-of-the-art lattice-based IBE schemes (without equality test). In this paper, we propose a semi-generic construction of CCA-secure lattice-based IBEET from a certain class of lattice-based IBE schemes. As a result, we obtain the first lattice-based IBEET schemes with adaptive security and CCA security in the standard model. Furthermore, our semi-generic construction can use several state-of-the-art lattice-based IBE schemes as underlying schemes. Then, we have adaptively secure lattice-based IBEET schemes whose public keys have only poly-log matrices

Characterization of the functions and proteomes associated with membrane rafts in chicken sperm

Cellular membranes are heterogeneous, and this has a great impact on cellular function. Despite the central role of membrane functions in multiple cellular processes in sperm, their molecular mechanisms are poorly understood. Membrane rafts are specific membrane domains enriched in cholesterol, ganglioside GM1, and functional proteins, and they are involved in the regulation of a variety of cellular functions. Studies of the functional characterization of membrane rafts in mammalian sperm have demonstrated roles in sperm-egg binding and the acrosomal reaction. Recently, our biochemical and cell biological studies showed that membrane rafts are present and might play functional roles in chicken sperm. In this study, we isolated membrane rafts from chicken sperm as a detergent-resistant membranes (DRM) floating on a density gradient in the presence of 1% Triton X-100, and characterized the function and proteomes associated with these domains. Biochemical comparison of the DRM between fresh and cryopreserved sperm demonstrated that cryopreservation induces cholesterol loss specifically from membrane rafts, indicating the functional connection with reduced post-thaw fertility in chicken sperm. Furthermore, using an avidin-biotin system, we found that sperm DRM is highly enriched in a 60 KDa single protein able to bind to the inner perivitelline layer. To identify possible roles of membrane rafts, quantitative proteomics, combined with a stable isotope dimethyl labeling approach, identified 82 proteins exclusively or relatively more associated with membrane rafts. Our results demonstrate the functional distinctions between membrane domains and provide compelling evidence that membrane rafts are involved in various cellular pathways inherent to chicken sperm

NOD1-Mediated Mucosal Host Defense against Helicobacter pylori

Infection of the stomach with Helicobacter pylori is an important risk factor for gastritis, peptic ulcer, and gastric carcinoma. Although it has been well established that persistent colonization by H. pylori is associated with adaptive Th1 responses, the innate immune responses leading to these Th1 responses are poorly defined. Recent studies have shown that the activation of nucleotide-binding oligomerization domain 1 (NOD1) in gastric epithelial cells plays an important role in innate immune responses against H. pylori. The detection of H. pylori-derived ligands by cytosolic NOD1 induces several host defense factors, including antimicrobial peptides, cytokines, and chemokines. In this paper, we review the molecular mechanisms by which NOD1 contributes to mucosal host defense against H. pylori infection of the stomach