1 research outputs found
Apoptotic Cell Membrane-Inspired Polymer for Immunosuppression
Apoptotic
cell death serves important roles in homeostasis by eliminating
dangerous, damaged, or unnecessary cells without causing an inflammatory
response by externalizing phosphatidylserine to the outer leaflet
in the phospholipid bilayer. In this study, we newly designed apoptotic
cell membrane-inspired monomer and polymer which have the phosphoryl
serine group as the anti-inflammatory functional moiety and demonstrate
here for the first time that administration of an apoptotic cell membrane-inspired
phosphorylserine polymer can protect murine macrophages (RAW 264.7)
from lipopolysaccharide-induced inflammation. Interestingly, statistical
copolymers with phosphorylcholine monomer that mimicked more precisely
the apoptotic cell membrane result in more effective suppression of
macrophage activation. This study provides new insights into the rational
design of effective polymeric materials for anti-inflammatory therapies