5,558 research outputs found
A new dawn? The Roman Catholic Church and environmental issues
This is a PDF version of an article published in New Blackfriars© 1997. The definitive version is available at www.blackwell-synergy.com.This article discusses the stance of the Roman Catholic Church on environmental issues and argues that the Church tends to stay on the fringe rather than get involved. Some of the ways in which Roman Catholic theologians have incorporated environmental issues into theological reflection is discussed, as are environmental challenges facing the Church in Britain (conservation, resources, biodiversity, animal welfare, biotechnology, cooperate/individual ethics, environmental justice, economics/policy development, and global issues)
What Happened to our Oats in 1953?
Stem rust, crown rust, temperatures, moisture and- believe it or not- hurricanes, tornadoes and windstorms all combined forces to wreak havoc with Iowa\u27s 1953 oat crop. Here is the story and a look ahead
Entanglement of distant optomechanical systems
We theoretically investigate the possibility to generate non-classical states
of optical and mechanical modes of optical cavities, distant from each other. A
setup comprised of two identical cavities, each with one fixed and one movable
mirror and coupled by an optical fiber, is studied in detail. We show that with
such a setup there is potential to generate entanglement between the distant
cavities, involving both optical and mechanical modes. The scheme is robust
with respect to dissipation, and nonlocal correlations are found to exist in
the steady state at finite temperatures.Comment: 12 pages (published with minor modifications
About Those New Oats - Burnett and Newton
These two new oat varieties will be available for planting in 1958. You can see them growing this year at Iowa State College or in the fields of certified seed producers. Here are the details on what you can expect
Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors
Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV. As attenuated tumour-selective oncolytic vaccinia viruses (VV) are already undergoing clinical evaluation, the goal of this study is to determine whether HDI can also enhance the potency of these poxviruses in infection-resistant cancer cell lines. Multiple HDIs were tested and Trichostatin A (TSA) was found to potently enhance the spread and replication of a tumour selective vaccinia virus in several infection-resistant cancer cell lines. TSA significantly decreased the number of lung metastases in a syngeneic B16F10LacZ lung metastasis model yet did not increase the replication of vaccinia in normal tissues. The combination of TSA and VV increased survival of mice harbouring human HCT116 colon tumour xenografts as compared to mice treated with either agent alone. We conclude that TSA can selectively and effectively enhance the replication and spread of oncolytic vaccinia virus in cancer cells. © 2010 MacTavish et al
Designing a Fully Online Social Marketing Course for 21st Century Learners
This paper focuses on the development of a Social Marketing for Public Health course created for health sciences students at the University of Ontario Institute of Technology (UOIT). The course was intended to help students develop the skills required for planning and delivering social marketing campaigns. The development of this course brought together members of the Faculty of Health Sciences and the Teaching and Learning Centre at UOIT with individuals from ChangeMakers, a Canadian social marketing agency. Designing authentic learning experiences, providing students of a range of technical backgrounds opportunities to demonstrate their achievement of the learning outcomes, building in a strong social element to suit the nature of subject area, and scaffolding student learning in a fully asynchronous learning environment were four overarching challenges faced by the development team. This paper addresses those challenges, discusses the theoretical underpinnings and learning theories – including Constructive Alignment and Universal Design for Learning – which guided this process and identifies steps for further developing this course for future offerings
A method for cell type marker discovery by high-throughput gene expression analysis of mixed cell populations
BACKGROUND: Gene transcripts specifically expressed in a particular cell type (cell-type specific gene markers) are useful for its detection and isolation from a tissue or other cell mixtures. However, finding informative marker genes can be problematic when working with a poorly characterized cell type, as markers can only be unequivocally determined once the cell type has been isolated. We propose a method that could identify marker genes of an uncharacterized cell type within a mixed cell population, provided that the proportion of the cell type of interest in the mixture can be estimated by some indirect method, such as a functional assay. RESULTS: We show that cell-type specific gene markers can be identified from the global gene expression of several cell mixtures that contain the cell type of interest in a known proportion by their high correlation to the concentration of the corresponding cell type across the mixtures. CONCLUSIONS: Genes detected using this high-throughput strategy would be candidate markers that may be useful in detecting or purifying a cell type from a particular biological context. We present an experimental proof-of-concept of this method using cell mixtures of various well-characterized hematopoietic cell types, and we evaluate the performance of the method in a benchmark that explores the requirements and range of validity of the approach
Elucidating the Influence of the Activation Energy on Reaction Rates by Simulations Based on a Simple Particle Model
An application for visualizing the dynamic properties of an equimolar binary mixture of isotropic reactive particles is presented. By introducing a user selectable choice for the activation energy, the application is useful to demonstrate qualitatively that the reaction rate depends on the above choice and on temperature. The application is based on a 2D realistic dynamic model where atoms move because of their thermal energies and the trajectories are determined by solving numerically Newton’s laws according to a Molecular Dynamics (MD) scheme. Collisions are monitored as time progresses, and every time the collision energy is larger than the selected activation energy, a reactive event occurs. By examining the time evolution of the configurations, it is possible to observe that the number of reactive collisions is always smaller than the total number of collisions. However, the number of reactive events increases on raising the temperature and/or by decreasing the activation energy. The above observations, as well as more quantitative analyses of the simulation data, are useful in elucidating the connections existing among particle kinetic energy, temperature, and activation energy of the reaction. The application can be used at different levels of detail and in different instruction levels. Qualitative visual observations of the progress of the reaction are suitable at all levels of instruction. Systematic investigations on the effect of changes of temperature and activation energy, suitable for senior high school and college courses and useful to gain insight into kinetic models and Arrhenius’ law, are also reported
Molecular formations in ultracold mixtures of interacting and noninteracting atomic gases
Atom-molecule equilibrium for molecular formation processes is discussed for
boson-fermion, fermion-fermion, and boson-boson mixtures of ultracold atomic
gases in the framework of quasichemical equilibrium theory. After presentation
of the general formulation, zero-temperature phase diagrams of the
atom-molecule equilibrium states are calculated analytically; molecular, mixed,
and dissociated phases are shown to appear for the change of the binding energy
of the molecules. The temperature dependences of the atom or molecule densities
are calculated numerically, and finite-temperature phase structures are
obtained of the atom-molecule equilibrium in the mixtures. The transition
temperatures of the atom or molecule Bose-Einstein condensations are also
evaluated from these results. Quantum-statistical deviations of the law of mass
action in atom-molecule equilibrium, which should be satisfied in mixtures of
classical Maxwell-Boltzmann gases, are calculated, and the difference in the
different types of quantum-statistical effects is clarified. Mean-field
calculations with interparticle interactions (atom-atom, atom-molecule, and
molecule-molecule) are formulated, where interaction effects are found to give
the linear density-dependent term in the effective molecular binding energies.
This method is applied to calculations of zero-temperature phase diagrams,
where new phases with coexisting local-equilibrium states are shown to appear
in the case of strongly repulsive interactions.Comment: 35 pages, 14 figure
Theory of x-ray absorption by laser-aligned symmetric-top molecules
We devise a theory of x-ray absorption by symmetric-top molecules which are
aligned by an intense optical laser. Initially, the density matrix of the
system is composed of the electronic ground state of the molecules and a
thermal ensemble of rigid-rotor eigenstates. We formulate equations of motion
of the two-color (laser plus x rays) rotational-electronic problem. The
interaction with the laser is assumed to be nonresonant; it is described by an
electric dipole polarizability tensor. X-ray absorption is approximated as a
one-photon process. It is shown that the equations can be separated such that
the interaction with the laser can be treated independently of the x rays. The
laser-only density matrix is propagated numerically. After each time step, the
x-ray absorption is calculated. We apply our theory to study adiabatic
alignment of bromine molecules (Br2). The required dynamic polarizabilities are
determined using the ab initio linear response methods coupled-cluster singles
(CCS), second-order approximate coupled-cluster singles and doubles (CC2), and
coupled-cluster singles and doubles (CCSD). For the description of x-ray
absorption on the sigma_g 1s --> sigma_u 4p resonance, a parameter-free
two-level model is used for the electronic structure of the molecules. Our
theory opens up novel perspectives for the quantum control of x-ray radiation.Comment: 14 pages, 4 figures, 1 table, RevTeX4, revise
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