The Ursinus Weekly, January 16, 1956

Thirteen seniors to appear in \u2756 Who\u27s who • February 20 set as deadline for May Day pageants • High school hears U.C. choral group • Dr. Miller\u27s class visits Bryn Mawr • Bloodmobile visits Ursinus Feb. 15 • Cupid hits U.C. over vacation • Editorial: How strong the foundation? • Sorority row • Fraternity row • Dillio gives some advice to the T-G. delinquents • The boy friend reveals realities of the roaring \u2720s • Schedule for final exams • Bears seek victory tonight after dropping four straight • Fords, Leopards drop grapplers; Garnet stopped by Bruins, 19-11 • Belles confident of another good year • Dave Burger receives All-American honors • Shreiner set to repeat as champshttps://digitalcommons.ursinus.edu/weekly/1441/thumbnail.jp

The Ursinus Weekly, October 15, 1956

Day-long program planned for Homecoming on Saturday, Oct. 20 • Ursinus seniors to hear businessmen • Customs, school rules discussed • International Relations Club holds reception • Three APEs congratulated • Ursinus Forum presents debate on politics • Convocation to be held Founders\u27 Day, October 21 • Religious emphasis week conference, October 21-24 • Y plans year\u27s activities at Fall retreat: Oct. 12-14 • Dean releases draft information • Students now teaching at schools in vicinity • Dr. M. W. Witmer dies, was retired Ursinus professor • Editorial: Raiding and responsibility; Direction of emphasis • Campus campaign: Republicans, Democrats • Bruin gridders take first victory; Trample Wilkes, 20-6: Arger, Padula and Rohm spark Ursinus attack • Belles romp over Gettysburg, 6-0 • Bear booters drop two to Drew, M\u27berg • Bears edged by Drexel as 2nd half drive falls short • Demas, O Chi hold fetehttps://digitalcommons.ursinus.edu/weekly/1412/thumbnail.jp

The Ursinus Weekly, March 4, 1957

Forum on student government scheduled for 8:00 tonight • March 15 date for annual show by students, faculty • Girls to discuss May Day on Wed. • Motion pictures viewed by Chemical Society • Chi Alpha schedules talk on integration • Curtain Club presents The Valiant, Feb. 26 • UC grad completes basic • Mary Jo Turtzo to represent UC in Glamour contest • Cub & Key Society requests outlines from junior men • 1957 Campus Chest fund drive • Annual drive begins today, closes on Friday, March 15 • YM-YW to sponsor music seminar; Begins Wednesday • YM-YW sponsor events for frosh • Local Rotarians set up scholarship to Ursinus • Frosh to present dance, The Golden nugget, Sat. • US foreign policy to be IRC program tonight • Editorial: Life for our organizations; It goes without saying • Letters to the editor • Obituary for a timid intellectual • Play review: The Valiant • He who hesitates • Ursinus five loses to Drexel, PMC; End with second worst slate, 0-16 • Belles top E. Stroudsburg; Win over William & Mary on weekend trip south • Padula emerges 4-year M. Atlantic champ; Wins second outstanding athlete award • Matmen gain first place tie with win over Drexel, 19-13 • Inside report on winless Bruinshttps://digitalcommons.ursinus.edu/weekly/1423/thumbnail.jp

Therapy for metastatic melanoma: the past, present, and future

Metastatic melanoma is the most aggressive form of skin cancer with a median overall survival of less than one year. Advancements in our understanding of how melanoma evades the immune system as well as the recognition that melanoma is a molecularly heterogeneous disease have led to major improvements in the treatment of patients with metastatic melanoma. In 2011, the US Food and Drug Administration (FDA) approved two novel therapies for advanced melanoma: a BRAF inhibitor, vemurafenib, and an immune stimulatory agent, ipilimumab. The success of these agents has injected excitement and hope into patients and clinicians and, while these therapies have their limitations, they will likely provide excellent building blocks for the next generation of therapies. In this review we will discuss the advantages and limitations of the two new approved agents, current clinical trials designed to overcome these limitations, and future clinical trials that we feel hold the most promise

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Paenibacillus infection with frequent viral coinfection contributes to postinfectious hydrocephalus in Ugandan infants

Postinfectious hydrocephalus (PIH), which often follows neonatal sepsis, is the most common cause of pediatric hydrocephalus worldwide, yet the microbial pathogens underlying this disease remain to be elucidated. Characterization of the microbial agents causing PIH would enable a shift from surgical palliation of cerebrospinal fluid (CSF) accumulation to prevention of the disease. Here, we examined blood and CSF samples collected from 100 consecutive infant cases of PIH and control cases comprising infants with non-postinfectious hydrocephalus in Uganda. Genomic sequencing of samples was undertaken to test for bacterial, fungal, and parasitic DNA; DNA and RNA sequencing was used to identify viruses; and bacterial culture recovery was used to identify potential causative organisms. We found that infection with the bacterium Paenibacillus, together with frequent cytomegalovirus (CMV) coinfection, was associated with PIH in our infant cohort. Assembly of the genome of a facultative anaerobic bacterial isolate recovered from cultures of CSF samples from PIH cases identified a strain of Paenibacillus thiaminolyticus. This strain, designated Mbale, was lethal when injected into mice in contrast to the benign reference Paenibacillus strain. These findings show that an unbiased pan-microbial approach enabled characterization of Paenibacillus in CSF samples from PIH cases, and point toward a pathway of more optimal treatment and prevention for PIH and other proximate neonatal infections

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