The importance of appropriate diagnostics in prosthetic joint infection:letter to the editor of BMC musculoskeletal disorders

Assessment of a new diagnostic test must be performed against an acceptable and validated standard to allow comparison with other studies. We are concerned that the adoption of lower diagnostic criteria in this paper has contributed to an over-diagnosis of prosthetic joint infection and makes interpretation of the results difficult

Electrochemical Benzylic C(sp3)−H Acyloxylation

[Image: see text] The development of sustainable C(sp(3))–H functionalization methods is of great interest to the pharmaceutical and agrochemical industries. Anodic oxidation is an efficient means of producing benzylic cations that can undergo subsequent in situ nucleophilic attack to afford functionalized benzylic products. Herein, we demonstrate the suitability of carboxylic acids as nucleophiles to yield benzylic esters. This method employs a series of secondary benzylic substrates and functionalized carboxylic acids and is demonstrated on a gram scale in flow

VCU Day of Service Toolkit (VCU-DST)

This team designed and developed a digital Day of Service Toolkit (VCU-DST) to help facilitate the planning and execution of community service projects by VCU students, faculty and staff. The VCU-DST includes guidance and relevant procedures for all the aspects of planning needed to execute both large-scale and small-scale projects, including resources for strategic partnerships, financial planning and event logistics and evaluation. The VCU-DST is designed to be utilized for day-of-service projects planned and initiated by VCU students, student leaders, and organizations at all levels (undergraduate, graduate, and professional). The VCU-DST is designed to be flexible and adaptable, assisting in the planning of events of all types and sizes for execution at future dates as the students and their leaders see fit. At the completion of this project, the digital VCU-DST will be delivered to our sponsor, Joyce Lloyd, the faculty advisor for the Graduate Student Government Association. It will also be made available to student leadership and service organizations to assist them in planning their community service project

Observation of a stronger-than-adiabatic change of light trapped in an ultrafast switched GaAs-AlAs microcavity

We study the time-resolved reflectivity spectrum of a switched planar GaAs-AlAs microcavity. Between 5 and 40 ps after the switching (pump) pulse we observe a strong excess probe reflectivity and a change of the frequency of light trapped in the cavity up to 5 linewidths away from the cavity resonance. This frequency change does not adiabatically follow the fast-changing cavity resonance. The frequency change is attributed to an accumulated phase change due to the time-dependent refractive index. An analytical model predicts dynamics in qualitative agreement with the experiments, and points to crucial parameters that control future applications.Comment: Discussed effect of probe bandwidth. Included functional forms of n(z) and R(z

Experimentally manipulating the landscape of fear to manage problem animals

We thank A. M. Clemo and H. J. Chalmers of Raptor Force for allowing us to observe their falconry activities. We thank F. M. Fazey, F. S. Morling, and S. K. Abdu for their field assistance. We thank the golf course managers for access to the courses and support throughout the study, in particular W. A. Hill. Funding for the project was received from the Department of Science and Technology-National Research Foundation (DST-NRF) Centre of Excellence fund, University of Cape Town.Peer reviewedPostprin

Impact of the national rotavirus vaccination programme on acute gastroenteritis in England and associated costs averted.

BACKGROUND: Introduction of infant oral rotavirus vaccination in the UK in July 2013 has resulted in decreased hospitalisations and Emergency Department (ED) visits for acute gastroenteritis (AGE), for both adults and children. We investigated reductions in AGE incidence seen in primary care in the two years after vaccine introduction, and estimated the healthcare costs averted across healthcare settings in the first year of the vaccination programme. METHODS: We used primary care data from the Clinical Practice Research Datalink and age-stratified time-series analyses to derive adjusted incidence rate ratios (IRRa) for AGE in the first two years of the post-vaccination era (July 2013-April 2015) compared to the pre-vaccination era (July 2008-June 2013). We estimated cases averted among children aged <5years in the first year of the vaccination programme by comparing observed numbers of AGE cases in 2013-2014 to numbers predicted from the time-series models. We then estimated the healthcare costs averted for general practice consultations, ED visits and hospitalisations. RESULTS: In general practice, AGE rates in infants (the target group for vaccination) decreased by 15% overall after vaccine introduction (IRRa=0.85; 95%CI=0.76-0.95), and by 41% in the months of historically high rotavirus circulation (IRRa=0.59; 95%CI=0.53-0.66). Rates also decreased in other young children and to a lesser degree in older individuals, indicating herd immunity. Across all three settings (general practice, EDs, and hospitalisations) an estimated 87,376 (95% prediction interval: 62,588-113,561) AGE visits by children aged <5years were averted in 2013-14, associated with an estimated £12.5million (9,209-16,198) reduction in healthcare costs. CONCLUSIONS: The marked decreases in the general practice AGE burden after rotavirus vaccine introduction mirror decreases seen in other UK healthcare settings. Overall, these decreases are associated with substantial averted healthcare costs

Transmitting G-Code with Geometry Commands for Extrusion Additive Manufacturing

G-code refers to text-based commands used to instruct a 3D printer how to construct an object. G-code is generated to represent each toolpath during the slicing process. Each toolpath is represented as a list of points that define the trajectory of the path to be printed. Additional commands are included to define the motion velocity and extrusion rate, called the feeds and speeds. These toolpaths and commands must be generated specific to the machine, material, and calibration settings that will be used during the print. This paper outlines a new approach for the slicing and g-code creation process that eliminates the need for outputting feeds and speeds in the slicing process. Instead, the slicer outputs g-code that defines the desired bead geometry as printed. The 3D printer can then read this geometry data and calculate the necessary feeds and speeds based on internal calibration data to successfully print the object.Mechanical Engineerin