Branding Places through Experiential Tourism: A Survey on the Features of the Experiential Product and Enterprises in Greek Regions

The focus of experiential tourism is for the consumer or visitor to experience the tourist destination and to actively interact with local people, cultures, and the place itself. In fact, it can be seen as a form of tourism that builds upon place identities, both tangible and intangible, by energetically introducing the visitor to the culture, history, nature, traditions, cuisine, and social life of a place. In doing so, the emotional, physical, or spiritual experience of the consumer becomes a dynamic source of place branding. The paper investigates the main features of experiential tourism in the Greek regions of Central Macedonia, and Eastern Macedonia and Thrace, and discusses their interactions with place identity. Our methodology consists of a qualitative survey based on semi-structured interviews with stakeholders and a thematic analysis to trace the main features of the experiential product and enterprises that develop such products. The paper concludes that experiential tourism in Greece bears many of the features highlighted in the literature. Furthermore, our findings underline some new aspects, especially the links between the experiential product, small and well-qualified enterprises, and a place’s tangible and intangible identities, which make experiential tourism an opportunity for locales and their branding

Branding Places through Experiential Tourism: A Survey on the Features of the Experiential Product and Enterprises in Greek Regions

The focus of experiential tourism is for the consumer or visitor to experience the tourist destination and to actively interact with local people, cultures, and the place itself. In fact, it can be seen as a form of tourism that builds upon place identities, both tangible and intangible, by energetically introducing the visitor to the culture, history, nature, traditions, cuisine, and social life of a place. In doing so, the emotional, physical, or spiritual experience of the consumer becomes a dynamic source of place branding. The paper investigates the main features of experiential tourism in the Greek regions of Central Macedonia, and Eastern Macedonia and Thrace, and discusses their interactions with place identity. Our methodology consists of a qualitative survey based on semi-structured interviews with stakeholders and a thematic analysis to trace the main features of the experiential product and enterprises that develop such products. The paper concludes that experiential tourism in Greece bears many of the features highlighted in the literature. Furthermore, our findings underline some new aspects, especially the links between the experiential product, small and well-qualified enterprises, and a place’s tangible and intangible identities, which make experiential tourism an opportunity for locales and their branding

GAA variants associated with reduced enzymatic activity but lack of Pompe-related symptoms, incidentally identified by exome sequencing

Pompe disease is a rare metabolic myopathy caused by pathogenic variants affecting the activity of the lysosomal glycogen-degrading enzyme acid alpha-glucosidase (GAA). Impaired GAA function results in the accumulation of undegraded glycogen within lysosomes in multiple tissues but predominantly affects the skeletal, smooth and cardiac muscle. The degree of residual enzymatic activity appears to roughly correlate with the age of onset and the severity of the clinical symptoms.Here, we report four siblings in which the GAA variants NM_000152.5:c.2237G > C p.(Trp746Ser) and NM_000152.5:c.266G > A p.(Arg89His) were identified as an incidental finding of clinical exome sequencing. These variants are listed in the ClinVar and the Pompe disease GAA variant databases but are reported here for the first time in compound heterozygosity. All four siblings displayed normal urine tetrasaccharide levels and no clinical manifestations related to Pompe disease. Nevertheless, GAA enzymatic activity was within the range for late onset Pompe patients.Our report shows an association between a novel genotype and attenuated GAA enzymatic activity. The clinical significance can only be established by the regular monitoring of these individuals. The study highlights the major challenges for clinical care arising from incidental findings of next generation sequencing

Inflammation and Venous Thromboembolism in Hospitalized Patients with COVID-19

Background: A link between inflammation and venous thromboembolism (VTE) in COVID-19 disease has been suggested pathophysiologically and clinically. The aim of this study was to investigate the association between inflammation and disease outcomes in adult hospitalized COVID-19 patients with VTE. Methods: This was a retrospective observational study, including quantitative and qualitative data collected from COVID-19 patients hospitalized at the Infectious Diseases Unit (IDU) of the University Hospital of Ioannina, from 1 March 2020 to 31 May 2022. Venous thromboembolism was defined as a diagnosis of pulmonary embolism (PE) and/or vascular tree-in-bud in the lungs. The burden of disease, assessed by computed tomography of the lungs (CTBoD), was quantified as the percentage (%) of the affected lung parenchyma. The study outcomes were defined as death, intubation, and length of hospital stay (LoS). A chi-squared test and univariate logistic regression analyses were performed in IBM SPSS 28.0. Results: After propensity score matching, the final study cohort included 532 patients. VTE was found in 11.2% of the total population. In patients with VTE, we found that lymphocytopenia and a high neutrophil/lymphocyte ratio were associated with an increased risk of intubation and death, respectively. Similarly, CTBoD > 50% was associated with a higher risk of intubation and death in this group of patients. The triglyceride–glucose (TyG) index was also linked to worse outcomes. Conclusions: Inflammatory indices were associated with VTE. Lymphocytopenia and an increased neutrophil-to-lymphocyte ratio negatively impacted the disease’s prognosis and outcomes. Whether these indices unfavorably affect outcomes in COVID-19-associated VTE must be further evaluated

Prone Positioning in Patients with COVID-19: Analysis of Multicenter Registry Data and Meta-analysis of Aggregate Data

Background/Aim: Evidence suggests a beneficial effect of prone positioning (PP) in COVID-19. Materials and Methods: Meta-analysis of individual (7 investigators’ groups) and aggregate data (PubMed/EMBASE) regarding the impact of PP on the ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PO2/FiO2) in patients with COVID-19. Results: Among 121 patients (mean age±SD 59.1±10.7 years, 55% males, 57% intubated) the mean post-versus pre- PP PO2/FiO2 difference was: (i) 50.4±64.3 mmHg, p<0.01, (ii) similar in awake (58.7±72.1 mmHg) versus intubated patients (44.1±57.5 mmHg, p=NS), (iii) inversely correlated with body mass index (r=–0.43, p<0.01). Meta-analysis of 23 studies (n=547, weighted age 58.3±4.1, 73% males, 59% intubated) showed a pooled PO2/FiO2 difference of 61.8 [95% confidence intervals=49.9-73.6] mmHg. Meta-regression analysis revealed no associations with baseline demographics, the time in PP before assessment, and the risk of bias of the studies. Conclusion: PP seems to improve oxygenation of patients with COVID-19. © 2022 International Institute of Anticancer Research. All rights reserved