34 research outputs found
Pseudosarcomatous myofibroblastic lesion of the urinary bladder: A rare entity posing a diagnostic challenge and therapeutic dilemma
<p>Abstract</p> <p>Background</p> <p>Pseudosarcomatous myofibroblastic lesions of the urinary bladder are relatively rare entities of an uncertain pathogenesis and benign indolent nature.</p> <p>Case presentation</p> <p>We present an extremely rare case of an ALK-1-positive pseudosarcomatous myofibroblastic lesion of the urinary bladder, which was initially misinterpreted as a low-grade leiomyosarcoma of myxoid subtype on histologic examination owing to prominent atypia, high mitotic activity, abnormal mitotic figures and infiltration of the bladder wall. Although the histologic features were suggestive of a sarcoma, the correct diagnosis was finally established and radical surgical treatment was subsequently avoided. The patient is currently free of disease without any evidence of tumor recurrence or metastasis at 3 years post-operatively.</p> <p>Conclusion</p> <p>The key differentiating point rests in distinguishing the aforementioned mass forming lesion from the myxoid subtype of low-grade leiomyosarcoma in order to avoid unnecessary radical therapy.</p
Leiomyosarcoma of the Prostate: Case Report and Review of 54 Previously Published Cases
Prostate leiomyosarcoma is an extremely rare and highly aggressive neoplasm that accounts for less than 0.1% of primary prostate malignancies. We present a patient with primary leiomyosarcoma of the prostate and review 54 cases reported in the literature to discuss the clinical, diagnostic and therapeutic aspects of this uncommon tumor. Median survival was estimated at 17 months (95% C.I. 20.7–43.7 months) and the 1-, 3-, and 5-year actuarial survival rates were 68%, 34%, and 26%, respectively. The only factors predictive of long-term survival were negative surgical margins and absence of metastatic disease at presentation. A multidisciplinary approach is necessary for appropriate management of this dire entity
Diagnosis and Management of Postpercutaneous Nephrolithotomy Residual Stone Fragments
Residual stone fragments can occur in up to 8% of patients who are
treated with percutaneous nephrolithotomy (PCNL). When left untreated,
approximately half of these patients will experience a stone-related
event, for which more than half will need a secondary surgical
intervention. Predictors of adverse events are a residual fragment
larger than 2 mm that is located in the pelvis or ureter. Preventive
measures for the creation of residual fragments include a carefully
selected access giving exposure to the bulk of the stone, the creation
of multiple tracts, the use of single pulse pneumatic lithotripsy, the
prevention of stone migration with ureteral balloons or stone cones, and
careful flushing of the stones from the collecting system. Plain
radiography of the kidneys, ureters, and bladder, linear tomography, and
ultrasonography have all been used to judge the result of PCNL and to
detect the presence of residual fragments. Thin-slice, unenhanced
helical CT, however, is more sensitive and should be performed at 1
month after surgery. While medical therapy and shockwave lithotripsy
possess a minor role, second-look flexible nephroscopy and/or flexible
ureterorenoscopy seem to be the treatments of choice for residual stone
fragments after PCNL
A Novel Thermo-Expandable Ureteral Metal Stent for the Minimally Invasive Management of Ureteral Strictures
The Impact of COVID-19 Disease on Urology Practice
The diagnosis and timely treatment of cancer patients should not be
compromised during an infectious disease pandemic. The pandemic of
coronavirus disease 2019 (COVID-19) has serious implications on urology
practice and raises particular questions for urologists about the
management of different conditions. It was recommended to cancel most of
the elective urological surgeries. Urological cancers surgeries that
should be prioritized are radical cystectomy for selective tumors,
orchiectomy for suspected testicular tumors, nephrectomy for c T3+,
nephroureterectomy for high-grade disease, and radical adrenalectomy for
tumors >6 cm or adrenal carcinoma. Most prostatectomies can be delayed
without compromising the survival rate of patients. Urological
emergencies should be treated adequately even during this pandemic.
There is a potential risk of coronavirus diffusion during minimally
invasive procedures performed. It is crucial to use specific precautions
when urologists performed those type of surgeries. It was also
recommended to suspend the kidney transplantation program during the
COVID-19 pandemic except for specific cases. In this review, we
discussed the triage of urological surgeries, the risk of minimally
invasive urological procedure, the kidney transplantation challenges,
the systemic therapies, intravesical instillation of Bacillus
Calmette-Guerin (BCG), endourology, teleconferencing, and telemedicine
application in urology during the COVID-19 pandemic
Molecular pathogenetics of renal cancer
Recent developments in genetics and molecular biology have led to an
increased understanding of the pathobiology of renal cancer. Thorough
knowledge of the molecular pathways associated with renal cancer is a
prerequisite for novel potential therapeutic interventions. Studies are
ongoing to evaluate novel anticancer agents that target specific
molecular entities. This article reviews current knowledge on the
genetics and molecular pathogenesis of sporadic and inherited forms of
renal cancer. Copyright (c) 2006 S. Karger AG, Basel
Intravesical treatment of bladder pain syndrome/interstitial cystitis: from the conventional regimens to the novel botulinum toxin injections
Update on cystine stones: current and future concepts in treatment
Cystine stones are relatively uncommon compared with other stone
compositions, constituting just 1% to 2% of adult urinary tract stone
diseases, and accounting for up to 10% of pediatric stone diseases. Two
responsible genes of cystinuria have been identified, the SLC3A1 and the
SLC7A9. Cystinuria is diagnosed by family history, stone analysis, or by
measurement of urine cystine excretion. Current treatments for
cystinuria include increased fluid intake to increase cystine solubility
by maintaining daily urine volume of greater than 3 Liter (L). Limiting
sodium and protein intake can decrease cystine excretion. When
conservative therapy fails, then pharmacologic therapy may be effective.
Alkaline urine pH in the 7.0-7.5 range will reduce cystine solubility
and can be achieved by the addition of alkali therapy. If these measures
fail, cystine-binding thiol drugs such as tiopronin and D-penicillamine
are considered. These compounds bind cysteine and prevent the formation
of less soluble cystine. These drugs, however, have poor patient
compliance due to adverse effects. Captopril can be useful in the
treatment of cystine stones but the drug has not been tested in rigorous
clinical trials. Novel potential therapies such as alpha-lipoic acid and
crystal growth inhibitors (L-cystine dimethyl ester (L-CDME) and
L-cystine methyl ester (L-CME)) were developed and tested in animals.
Those therapies showed promising results. Compliance with treatment was
associated with a lower rate of cystine stone formation