Fractal Growth on the Surface of a Planet and in Orbit around it

Fractals are defined as geometric shapes that exhibit symmetry of scale. This simply implies that fractal is a shape that it would still look the same even if somebody could zoom in on one of its parts an infinite number of times. This property is also called self-similarity with several applications including nano pharmacology and drug nano carriers. We are interested in the study of the properties of fractal aggregates in a microgravity environment above an orbiting spacecraft. To model the effect we use a complete expression for the gravitational acceleration. In particular on the surface of the Earth the acceleration is corrected for the effect of oblateness and rotation. In the gravitational acceleration the effect of oblateness can be modeled with the inclusion of a term that contains the J2 harmonic coefficient, as well as a term that depends on the square of angular velocity of the Earth. In orbit the acceleration of gravity at the point of the spacecraft is a function of the orbital elements and includes only in our case the J2 harmonic since no coriolis force is felt by the spacecraft. Using the fitting parameter d = 3.0 we have found that the aggregate monomer number N is not significantly affected and exhibits a minute 0.0001% difference between the geocentric and areocentric latitudes of 90 degrees and 0 degrees. Finally for circular and elliptical orbits around Earth and Mars of various inclinations and eccentricities the aggregate monomer number is not affected at all at the orbital altitude of 300 km.Comment: 24 pages, 10 Figures, Springer journal Microgravity - Science and Technology, 2014 (accepted, in press

Natural Products for Neurodegeneration: Regulating Neurotrophic Signals

Neurodegenerative disorders (NDs) are heterogeneous groups of ailments typically characterized by progressive damage of the nervous system. Several drugs are used to treat NDs but they have only symptomatic benefits with various side effects. Numerous researches have been performed to prove the advantages of phytochemicals for the treatment of NDs. Furthermore, phytochemicals such as polyphenols might play a pivotal role in rescue from neurodegeneration due to their various effects as anti-inflammatory, antioxidative, and antiamyloidogenic agents by controlling apoptotic factors, neurotrophic factors (NTFs), free radical scavenging system, and mitochondrial stress. On the other hand, neurotrophins (NTs) including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT4/5, and NT3 might have a crucial neuroprotective role, and their diminution triggers the development of the NDs. Polyphenols can interfere directly with intracellular signaling molecules to alter brain activity. Several natural products also improve the biosynthesis of endogenous genes encoding antiapoptotic Bcl-2 as well as NTFs such as glial cell and brain-derived NTFs. Various epidemiological studies have demonstrated that the initiation of these genes could play an essential role in the neuroprotective function of dietary compounds. Hence, targeting NTs might represent a promising approach for the management of NDs. In this review, we focus on the natural product-mediated neurotrophic signal-modulating cascades, which are involved in the neuroprotective effectsThis work was funded by the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University through the Fast-track Research Funding ProgramS

Point Cloud Subjective Evaluation Methodology based on 2D Rendering

Point clouds are one of the most promising technologies for 3D content representation. In this paper, we describe a study on quality assessment of point clouds, degraded by octree-based compression on different levels. The test contents were displayed using Screened Poisson surface reconstruction, without including any textural information, and they were rated by subjects in a passive way, using a 2D image sequence. Subjective evaluations were performed in five independent laboratories in different countries, with the inter-laboratory correlation analysis showing no statistical differences, despite the different equipment employed. Benchmarking results reveal that the state-of-the-art point cloud objective metrics are not able to accurately predict the expected visual quality of such test contents. Moreover, the subjective scores collected from this experiment were found to be poorly correlated with subjective scores obtained from another test involving visualization of raw point clouds. These results suggest the need for further investigations on adequate point cloud representations and objective quality assessment tools

Exacerbation of N-nitrosodiethylamine Induced Hepatotoxicity and DNA Damage in Mice Exposed to Chronic Unpredictable Stress

Psychological stress contributes to increased susceptibility to a number of diseases including cancer. The present study was designed to assess the effect of chronic unpredictable stress on N-nitrosodiethylamine induced liver toxicity in terms of in vivo antioxidant status and DNA damage in Swiss albino mice. The animals used in this study were randomized into different groups based on the treatment with N-nitrosodiethylamine or chronic unpredictable stress alone and post-stress administration of N-nitrosodiethylamine. The mice were sacrificed after 12 weeks of treatment, and the status of major enzymatic and non-enzymatic antioxidants, liver function markers, lipid peroxidation and the extent of DNA damage were determined in circulation and liver tissues of all the groups. The N-nitrosodiethylamine treated group showed significantly compromised levels of the antioxidant enzymes, lipid peroxidation, and the liver function markers with enhanced DNA damage as compared to chronic unpredictable stress or control groups. A similar but less typical pattern observed in the chronic unpredictable stress treated mice. All the measured biochemical parameters were significantly altered in the group treated with the combination of chronic unpredictable stress and N-nitrosodiethylamine when compared to controls, or chronic unpredictable stress alone and/or N-nitrosodiethylamine alone treated groups. Thus, exposure to continuous, unpredictable stress conditions even in general life may significantly enhance the hepatotoxic potential of N-nitrosodiethylamine through an increase in the oxidative stress and DNA damage

Diagnostic value of anti-cyclic citrullinated peptide antibodies in Greek patients with rheumatoid arthritis

Background: Anti-cyclic citrullinated peptide (anti-CCP) antibodies have been of diagnostic value in Northern European Caucasian patients with rheumatoid arthritis ( RA). In these populations, anti-CCP antibodies are associated with the HLA-DRB1 shared epitope. We assessed the diagnostic value of anti-CCP antibodies in Greek patients with RA where the HLA shared epitope was reported in a minority of patients. Methods: Using an enzyme-linked immunosorbent assay ( ELISA) (CCP2) kit, we tested anti-CCP antibodies in serum samples from 155 Greek patients with RA, 178 patients with other rheumatic diseases, and 100 blood donors. We also determined rheumatoid factor (RF) and compared it to anti-CCP antibodies for area under the curve (AUC), sensitivity, specificity and likelihood ratios. Results: Sensitivity of anti-CCP2 antibodies and RF for RA was 63.2% and 59.1%, and specificity was 95.0% and 91.2%, respectively. When considered simultaneously, the AUC for anti-CCP antibodies was 0.90 with 95% CI of 0.87 to 0.93 and the AUC for RF was 0.71 with 95% CI of 0.64 to 0.77. The presence of both antibodies increased specificity to 98.2%. Anti-CCP antibodies were positive in 34.9% of RF-negative RA patients. Anti-CCP antibodies showed a correlation with the radiographic joint damage. Anti-CCP-positive RA patients had increased the swollen joint count and serum CRP concentration compared to anti-CCP-negative RA patients (Mann-Whitney U test, p = 0.01, and p < 0.001, respectively). However, no correlation was found between anti-CCP antibodies and DAS28 score ( r = 0.13, p = 0.12). Conclusion: In Greek patients with RA, anti-CCP2 antibodies exhibit a better diagnostic value than RF and a correlation with radiological joint damage and therefore are useful in everyday rheumatology practice