Tetramic and Tetronic Acids as Scaffolds in Bioinorganic and Bioorganic Chemistry

Tetramic and tetronic acids are naturally occurring molecules with a variety of biological activities. In this review article, we present the general strategies for the synthesis of these compounds and we reveal the functionalized groups that are responsible for their properties. We also set out their coordinating modes with up-to-date bibliographical references

Novel short-step synthesis of optically active tetronic acids from chiral α-hydroxy acids mediated by 1-hydroxybenzotriazole

A novel method for the synthesis of functionalized γ-hydroxy acids and optically active tetronic acids is reported. The synthesis is simple and the compounds are produced in good yields (45-81%). Measurements of their optical rotations show that the reaction proceeds without or with partial racemization of the starting materials

Tetramic and tetronic acids as scaffolds in bioinorganic and bioorganic chemistry

Tetramic and tetronic acids are naturally occurring molecules with a variety of biological activities. In this review article, we present the general strategies for the synthesis of these compounds and we reveal the functionalized groups that are responsible for their properties. We also set out their coordinating modes with up-to-date bibliographical references. Copyright © 2010 G. Athanasellis et al