Comparison of health- related quality of life between obese women with binge eating disorder and obese women without binge eating disorder

Nowadays obesity It is an important factor in onset of disease and early mortality followed by personal and social consequences.  One of the effects of the obesity is its impacts on quality of individual's life while some studies proved that Binge eating disorder affects obesity consequences. So  in this cross sectional study, among all of clients to obesity clinic Sina Hospital with sampling   health- related quality of life61  obese women with  binge eating disorder was compared with those of 74obese women withoutbinge eating disorder through performing sf-36 questionnaire and the results were analyzed by using independent t-test. Results showed that in six subscales of health-related Quality of Life, the group of women without binge eating disorder ranked over those women with binge eating disorder. Parallel to weight loss in obese and overweight people and due to its impacts on the consequences over the obese people, it seems necessary to equally focus on the treatment of binge eating disorder simultaneously

Paraoxonase and Arylesterase activities of human serum paraoxonase in coronary artery disease

Introduction: Considering the importance of serum paraoxonase (PON1) in preventing fromproduction of oxidized low-density lipoprotein (LDL), and consequently, its role in prohibiting fromdevelopment of atherosclerosis, we investigated paraoxonase and arylesterase activities of PON1 inpatients with coronary artery disease (CAD) and with different coronary stenosis.Materials and Methods: In the present study, 120 patients with CAD were examined and theirstenosis documented by coronary angiography. Then, the patients were divided into two groups: 60patients with less than 50% of stenosis and 60 patients with more than 70% of stenosis. Paraoxonaseand arylesterase activity was measured with substrates of paraoxon and phenylacetate, respectively.The effects of eight drugs, which are prescribed in cardiovascular diseases, were assayed onparaoxonase activity.Results: There were no significant differences in LDL-C, total cholesterol and triglyceride levelsbetween two groups, but HDL levels in patients with >70% of stenosis were significantly decreased ascompared with those of patients who had <50% of stenosis (P<0.03). Both paraoxonase andarylesterase activity in patients with >70% of stenosis were significantly lower (P<0.05) than patientswith<50% of stenosis.Conclusion: Paraoxonase and arylesterase activities of PON1 and HDL levels in patients with>70% of stenosis were lower than patients with <50% of stenosis. In other words, the PON1 activitiesand HDL levels decrease with progression of atheroma. Therefore, the study might support theimportant role of HDL-bound PON1 in preventing from formation of ox-LDL and its anti-atherogenicactivity

Zinc- and Copper-Doped Mesoporous Borate Bioactive Glasses: Promising Additives for Potential Use in Skin Wound Healing Applications

In this study, zinc (Zn)- and copper (Cu)-doped 13-93B3 borate mesoporous bioactive glasses (MBGs) were successfully synthesized using nitrate precursors in the presence of Pluronic P123. We benefited from computational approaches for predicting and confirming the experimental findings. The changes in the dynamic surface tension (SFT) of simulated body fluid (SBF) were investigated using the Du Noüy ring method to shed light on the mineralization process of hydroxyapatite (HAp) on the glass surface. The obtained MBGs were in a glassy state before incubation in SBF. The formation of an apatite-like layer on the SBF-incubated borate glasses was investigated by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The incorporation of Zn and Cu into the basic composition of 13-93B3 glass led to changes in the glass transition temperature (Tg) (773 to 556 °C), particle size (373 to 64 nm), zeta potential (−12 to −26 mV), and specific surface area (SBET) (54 to 123 m2/g). Based on the K-means algorithm and chi-square automatic interaction detection (CHAID) tree, we found that the SFT of SBF is an important factor for the prediction and confirmation of the HAp mineralization process on the glasses. Furthermore, we proposed a simple calculation, based on SFT variation, to quantify the bioactivity of MBGs. The doped and dopant-free borate MBGs could enhance the proliferation of mouse fibroblast L929 cells at a concentration of 0.5 mg/mL. These glasses also induced very low hemolysis (Pseudomonas aeruginosa. In summary, we showed that Cu-/Zn-doped borate MBGs can be fabricated using a cost-effective method and also show promise for wound healing/skin tissue engineering applications, as especially supported by the cell test with fibroblasts, good compatibility with blood, and antibacterial properties