BIOLOGIC DRUG PREFERENCES OF TURKISH RHEUMATOLOGISTS IN SPONDILOARTROPATHY PATIENTS WITH ADVANCED CHRONIC RENAL DISEASE

[Abstract Not Available

Single port/incision laparoscopic surgery compared with standard three-port laparoscopic surgery for appendicectomy : a randomised controlled trial

PMID: 23111090 [PubMed - indexed for MEDLINE] PMCID: PMC3543288 Free PMC ArticlePeer reviewedPublisher PD

Imaging of subsurface lineaments in the southwestern part of the Thrace Basin from gravity data

Linear anomalies, as an indicator of the structural features of some geological bodies, are very important for the interpretation of gravity and magnetic data. In this study, an image processing technique known as the Hough transform (HT) algorithm is described for determining invisible boundaries and extensions in gravity anomaly maps. The Hough function implements the Hough transform used to extract straight lines or circles within two-dimensional potential field images. It is defined as image and Hough space. In the Hough domain, this function transforms each nonzero point in the parameter domain to a sinusoid. In the image space, each point in the Hough space is transformed to a straight line or circle. Lineaments are depicted from these straight lines which are transformed in the image domain. An application of the Hough transform to the Bouguer anomaly map of the southwestern part of the Thrace Basin, NW Turkey, shows the effectiveness of the proposed approach. Based on geological data and gravity data, the structural features in the southwestern part of the Thrace Basin are investigated by applying the proposed approach and the Blakely and Simpson method. Lineaments identified by these approaches are generally in good accordance with previously-mapped surface faults

Poly-3-hydroxybutyrate-producing extreme halophilic archaeon: Haloferax sp. MA10 isolated from Çamalti{dotless} Saltern, İzmir [İzmir Çamalti{dotless} Tuzlasi{dotless}'ndan izole edilen poli-3-hidroksibütirat üreticisi ekstrem halofilik arkeon: Haloferax sp. MA10]

İzmir Çamalti{dotless} Saltern is the biggest seawater-based saltern in Turkey. To date, it has not been investigated extensively for the existence of poly-3-hydroxybutyrate (PHB)-producing species. In this study, 14 extremely halophilic archaea were isolated, purified, and screened for PHB production. One strain was then selected as the best PHB producer, further cultivated in different PHB media, and compared with a positive control, Haloferax mediterranei ATCC 33500. PHB was extracted from cells and measured with a spectrophotometer, and then the amount of PHB was measured through comparison with standard PHB. The detected high PHB yield was 6.53% of the dry cell weight in the PHB medium supplemented with acetate. Partial 16S rRNA gene sequence analysis showed 99% similarity to Haloferax alexandrinus strain TM T; therefore, the strain was named Haloferax sp. MA10. Haloferax sp. MA10 and Haloferax alexandrinus TMT have some differences in phenotypic and biochemical properties. With this study, the discovery of PHB-producing extreme halophilic archaeon Haloferax sp. MA10 at İzmir's Çamalti{dotless} Saltern is reported for the first time. © TÜBITAK

Beneficial effects of agomelatine in experimental model of sepsis-related acute kidney injury [Sepsis nedenli akut böbrek hasarında agomelatinin etkilerinin değerlendirilmesi]

PubMed ID: 27193977BACKGROUND: Sepsis-related acute kidney injury (AKI) is a serious complication of sepsis. Problems persist regarding early diagnosis and treatment of AKI. The aim of the present study was to evaluate the efficacy of agomelatine, which is primarily known for its positive effects on depressive and anxiety disorders in sepsis-related AKI. METHODS: Sepsis model was created with cecal ligation puncture (CLP). Rats were separated into 4 groups of 8 each: the control group, the sham-operated group, the CLP+saline group, and the CLP+agomelatine group. Agomelatine was administered intraperitoneally in doses of 20 mg/kg. RESULTS: In the agomelatine group, reductions were observed in levels of tumor necrosis factor ? (TNF-?), malondialdehyde (MDA), blood urea nitrogen (BUN), and creatinine, as well as in histological kidney scores, compared to the non-treated group. In addition, it was demonstrated that agomelatine treatment had positive effect on sepsis-induced morphological damage to renal and tubular tissues. CONCLUSION: Agomelatine showed strong efficacy in sepsis-related AKI, demonstrated with histological and biochemical results in an experimental model. It is believed that antioxidant and pro-inflammatory effects of agomelatine are responsible for the improvement in kidneys. © 2016 TJTES

OPTIMIZATION OF PHENOLIC COMPOUNDS EXTRACTION FROM PURPLE BASIL LEAF BY CONVENTIONAL AND MICROWAVE ASSISTED EXTRACTION METHODS

The present study aimed to determine the optimum extraction conditions of conventional solvent extraction (CSE) and microwave-assisted extraction (MAE) techniques to obtain maximum total phenolic (TPC), total flavonoid (TFC), total anthocyanin (TAC) and antioxidant capacity (AA). Response surface methodology (RSM) and central composite design (CCD) were used to determine optimum points of CSE and MAE. Both two extraction methods, all parameters significantly affected TPC, AA, TFC and TAC (p<0.05). MAE showed higher bioactive compounds yield than that of CSE. Optimum point for CSE and MAE was found to be 60 degrees C and 30 min and 591.83 W and 2.98 min respectively. TPC, AA, TFC and TAC were obtained as 33.81mg/g, 160.27 mg/g, 11.89 mg/g and 331.01 mg/kg for CSE and 62.99 mg/g, 214.62 mg/g, 21.80 mg/g and 3462.93 mg/kg for MAE respectively. This study recommended that the MAE should be used for the extraction of PBL to increase phenolic extraction yield.WOS:0007020935000092-s2.0-8511792183