10 research outputs found
Fluid Mode Spectroscopy for measuring dynamic viscosity of fluids in open cylindrical containers
On a daily basis we stir tee or coffee with a spoon and leave it to rest. We
know empirically the larger the stickiness, viscosity, of the fluid, more
rapidly its velocity slows down. It is surprising, therefore, that the
variation has not been utilized for measuring (dynamic) viscosity of fluids.
This study shows that a spectroscopy decomposing a velocity field into fluid
modes (Stokes eigenmodes) allows us to measure accurately the dynamic
viscosity. The method, Fluid Mode Spectroscopy (FMS), is based on the fact that
each Stokes eigenmode has its inherent decay rate of eigenvalue and that the
dimensionless rate of the slowest decaying mode (SDM) is constant, dependent
only on the normalized shape of a fluid container, obtained analytically for
some shapes including cylindrical containers. The FMS supplements major
conventional measuring methods with each other, particularly useful for
measuring low dynamic viscosity.Comment: 18 pagese, 6 figure
Versican provides the provisional matrix for uterine spiral artery dilation and fetal growth
The extracellular matrix (ECM) in the endometrium plays a crucial role in mammalian pregnancy. We have shown that versican secreted from the endometrial epithelium promotes embryo implantation. Versican is a proteoglycan, a major player in the provisional matrix, and versikine, its N-terminal fragment cleaved by ADAMTS proteinases, serves as a bioactive molecule. Here, since versican expression in the placenta was dynamically altered in humans and mice, we investigated the role of versican in pregnancy using uterine-specific Vcan deletion mice (uKO mice) and ADAMTS-resistant versican expressing mice (V1R mice). uKO mice exhibited insufficient spiral artery dilation, followed by fetal growth restriction and maternal hypertension. Further analysis revealed impaired proliferation of tissue-resident natural killer cells required for spiral artery dilation. V1R mice showed the same results as the control, eliminating the involvement of versikine. Our results provide a new concept that versican, one factor of ECM, contributes to placentation and following fetal growth
Liver Cirrhosis and Hepatocellular Carcinoma Diagnosed from Chylothorax: A Case Report
A 71-year-old man visited our hospital with dyspnea and left pleural effusion. Left pleural effusion was diagnosed as chylothorax by thoracentesis. He had no history of trauma or surgery, and there were no findings of malignant lymphoma or thrombosis. Furthermore, he was diagnosed with liver cirrhosis and hepatocellular carcinoma by computed tomography and hematological examinations, and the chylothorax was considered to be caused by liver cirrhosis. We report a review of the literature with this case since it is relatively rare for cirrhosis and hepatocellular carcinoma diagnosed from chylothorax
Nivolumab for malignant transformation of ovarian mature cystic teratoma
Mature cystic teratoma of the ovary (MCT) occasionally undergoes malignant transformation (MT) that is resistant to chemotherapy and has a poor prognosis. We experienced a case of clinically aggressive MCT-MT that invades surrounding organs and tissues. Although tumor was resected entirely, a rapid tumor recurrence occurred during postoperative chemotherapy (paclitaxel + ifosfamide + cisplatin). The results of comprehensive genomic profiling test performed early in the postoperative period showed a high tumor mutational burden of 23 mutations/Mb. Treatment with nivolumab monotherapy has promptly been initiated and has been very successful for more than one year
Membrane Transport Mechanisms of Quinidine and Procainamide in Renal LLC-PK1 and Intestinal LS180 Cells
Instability of non-REM sleep in older women evaluated by sleep-stage transition and envelope analyses
Versican provides the provisional matrix for uterine spiral artery dilation and fetal growth
The extracellular matrix (ECM) in the endometrium plays a crucial role in mammalian pregnancy. We have shown that versican secreted from the endometrial epithelium promotes embryo implantation. Versican is a proteoglycan, a major player in the provisional matrix, and versikine, its N-terminal fragment cleaved by ADAMTS proteinases, serves as a bioactive molecule. Here, since versican expression in the placenta was dynamically altered in humans and mice, we investigated the role of versican in pregnancy using uterine-specific Vcan deletion mice (uKO mice) and ADAMTS-resistant versican expressing mice (V1R mice). uKO mice exhibited insufficient spiral artery dilation, followed by fetal growth restriction and maternal hypertension. Further analysis revealed impaired proliferation of tissue-resident natural killer cells required for spiral artery dilation. V1R mice showed the same results as the control, eliminating the involvement of versikine. Our results provide a new concept that versican, one factor of ECM, contributes to placentation and following fetal growth