Ambulatory Hysteroscopy Results Post-Menopause: Comparative Study Between Patients With and Without Metrorrhagia

Our objective was to compare the results of ambulatory hysteroscopy in postmenopausal women with and without uterine bleeding. A retrospective descriptive study was carried out on 236 women who were at least 2 years into the menopause, who were not undergoing hormone treatment and who had had abnormal pelvic ultrasound results. Of these women, 150 were asymptomatic and 86 reported haemorrhage. Diagnostic and operative outpatient hysteroscopy was performed between January 2002 and December 2003. There was no difference between the two groups regarding age of patients, age of menopause and presence of at least one of the risk factors for endometrial carcinoma evaluated, although obesity was more frequent in the symptomatic group. Abnormal ultrasound results for these women corresponded in the majority of cases to intracavitary disease, and the absence of organic endometrial pathology was 9.3% vs 11.3% in each group. The more frequent pathology was benign endometrial polyps (64% in bleeding patients and 84.7% in asymptomatic ones). Endometrial carcinoma was diagnosed in 23.3% of women with metrorrhagia and in 1.3% of asymptomatic women. We diagnosed 2.6% of malignancy inside polyps. Hysteroscopy results were confirmed by histology in 90.3% of cases. See and treat in one session was achieved in 91% of benign endometrial polyps. Ambulatory hysteroscopy has high sensitivity and specificity for intracavitary pathology and high tolerability and safety. See and treat in one session can be achieved in the majority of lesions with indication for excision. These results make us advise our menopausal patients with abnormal uterine bleeding to undergo diagnostic hysteroscopy complemented with biopsy

Case Report of Malignant Endometrial Polyps

The aims of this retrospective review were to determine the frequency of malignant endometrial polyps diagnosed with ambulatory hysteroscopy in the Obstetrics/Gynaecology Department of HDE, Lisbon, between January 2001 and December 2005 and to characterize these cases according to risk factors, sonographic and endoscopic findings tumoral histology, and tumor stage.We found seven cases of malignant endometrial polyps in a total of 1333 polyps initially diagnosed: an incidence rate of 0. 53%. These seven patients had a mean age of 68 years (55–82 years), and all were postmenopausal, with five having one risk factor each for endometrial cancer. Metrorrhagia was present in six of the seven patients(85.7%). Ultrasonography was abnormal in all seven patients, with a mean endometrial thickness of 26 mm(range: 12–44 mm). The hysteroscopy images suggested malignancy in all cases. All except one patient had a single polyp. The polyps had volumes between 1.5 and 3 cm; two were removed completely and five were biopsed. The histological subtype was: mixed endometrioid/serous papillary or clear cell (2), adenocarcinoma with squamous differentiation (2), carcinosarcoma (2), and clear cell carcinoma (1). Malignancy inside polyps is rare, but diagnostic hysteroscopy with visual guided biopsies can identify these cases in the earlier stages. The risk factors are not different from those of other endometrial carcinomas, but the histological subtype seems to point to more aggressive cancers

Myomectomy in Early Pregnancy - A Case Report

Uterine leiomyomas are by far the most common benign tumours of the female genital tract. The true incidence of leiomyomas during pregnancy is, however, unknown. Although leiomyomas usually remain asymptomatic during pregnancy, they may complicate its course. The management of leiomyoma during pregnancy is medical, but, in rare circumstances, surgical intervention and myomectomy may be required. A case of myomectomy in early pregnancy is described

Objective quality prediction model for lost frames in 3D video over TS

This paper proposes an objective model to predict the quality of lost frames in 3D video streams. The model is based only on header information from three different packet-layer levels: Network Abstraction Layer (NAL), Packetised Elementary Streams (PES) and Transport Stream (TS). Transmission errors leading to undecodable TS packets are assumed to result in frame loss. The proposed method estimates the size of the lost frames, which is used as a model parameter to predict their objective quality measured as the Structural Similarity Index Metric (SSIM). The results show that SSIM of missing stereoscopic frames in 3D coded video can be predicted with Root Mean Square Error (RMSE) accuracy of about 0.1 and Pearson correlation coefficient of 0.8, taking the SSIM of uncorrupted frames as reference. It is concluded that the proposed model is capable of estimating the SSIM quite accurately using only the lost frames estimated sizes.info:eu-repo/semantics/acceptedVersio

Global Hopf bifurcation in the ZIP regulatory system

Regulation of zinc uptake in roots of Arabidopsis thaliana has recently been modeled by a system of ordinary differential equations based on the uptake of zinc, expression of a transporter protein and the interaction between an activator and inhibitor. For certain parameter choices the steady state of this model becomes unstable upon variation in the external zinc concentration. Numerical results show periodic orbits emerging between two critical values of the external zinc concentration. Here we show the existence of a global Hopf bifurcation with a continuous family of stable periodic orbits between two Hopf bifurcation points. The stability of the orbits in a neighborhood of the bifurcation points is analyzed by deriving the normal form, while the stability of the orbits in the global continuation is shown by calculation of the Floquet multipliers. From a biological point of view, stable periodic orbits lead to potentially toxic zinc peaks in plant cells. Buffering is believed to be an efficient way to deal with strong transient variations in zinc supply. We extend the model by a buffer reaction and analyze the stability of the steady state in dependence of the properties of this reaction. We find that a large enough equilibrium constant of the buffering reaction stabilizes the steady state and prevents the development of oscillations. Hence, our results suggest that buffering has a key role in the dynamics of zinc homeostasis in plant cells.Comment: 22 pages, 5 figures, uses svjour3.cl

Coevolution of Generative Adversarial Networks

Generative adversarial networks (GAN) became a hot topic, presenting impressive results in the field of computer vision. However, there are still open problems with the GAN model, such as the training stability and the hand-design of architectures. Neuroevolution is a technique that can be used to provide the automatic design of network architectures even in large search spaces as in deep neural networks. Therefore, this project proposes COEGAN, a model that combines neuroevolution and coevolution in the coordination of the GAN training algorithm. The proposal uses the adversarial characteristic between the generator and discriminator components to design an algorithm using coevolution techniques. Our proposal was evaluated in the MNIST dataset. The results suggest the improvement of the training stability and the automatic discovery of efficient network architectures for GANs. Our model also partially solves the mode collapse problem.Comment: Published in EvoApplications 201

Repetições de dinucleotídeos em ESTs de frutos e sementes de guaraná.

O objetivo deste trabalho foi avaliar as repetições de dinucleotídeos em 5.969 unidades transcricionais (ESTs "singlets" and "contigs") de frutos e sementes de guaranazeiro mantidos no banco de dados da REALGENE e comparar com aqueles encontrados em bibliotecas genômicas enriquecidas para repetições AG/TC AC/TG

Resistência em campo de híbridos comerciais e experimentais de tomate para processamento a geminivírus.

No presente trabalho, buscouse avaliar a resistência de híbridos comerciais e experimentais à geminivirose em condições de campo na região de Morrinhos.Trabalho