113 research outputs found
The Fermion Monte Carlo revisited
In this work we present a detailed study of the Fermion Monte Carlo algorithm
(FMC), a recently proposed stochastic method for calculating fermionic
ground-state energies [M.H. Kalos and F. Pederiva, Phys. Rev. Lett. vol. 85,
3547 (2000)]. A proof that the FMC method is an exact method is given. In this
work the stability of the method is related to the difference between the
lowest (bosonic-type) eigenvalue of the FMC diffusion operator and the exact
fermi energy. It is shown that within a FMC framework the lowest eigenvalue of
the new diffusion operator is no longer the bosonic ground-state eigenvalue as
in standard exact Diffusion Monte Carlo (DMC) schemes but a modified value
which is strictly greater. Accordingly, FMC can be viewed as an exact DMC
method built from a correlated diffusion process having a reduced Bose-Fermi
gap. As a consequence, the FMC method is more stable than any transient method
(or nodal release-type approaches). We illustrate the various ideas presented
in this work with calculations performed on a very simple model having only
nine states but a full sign problem. Already for this toy model it is clearly
seen that FMC calculations are inherently uncontrolled.Comment: 49 pages with 4 postscript figure
Mechanisms of cisplatin resistance and targeting of cancer stem cells: Adding glycosylation to the equation
Cisplatin-based chemotherapeutic regimens are the most frequently used (neo)adjuvant treatments for the majority of solid tumors. While platinum-based chemotherapeutic regimens have proven effective against highly proliferative malignant tumors, significant relapse and progression rates as well as decreased overall survival are still observed. Currently, it is known that sub-populations of chemoresistant cells share biological properties with cancer stem cells (CSC), which are believed to be responsible for tumor relapse, invasion and ultimately disease dissemination through acquisition of mesenchymal cell traits. In spite of concentrated efforts devoted to decipher the mechanisms underlying CSC chemoresistance and to design targeted therapeutics to these cells, proteomics has failed to unveil molecular signatures capable of distinguishing between malignant and non-malignant stem cells. This has hampered substantial developments in this complex field. Envisaging a novel rationale for an effective therapy, the current review summarizes the main cellular and molecular mechanisms underlying cisplatin resistance and the impact of chemotherapy challenge in CSC selection and clinical outcome. It further emphasizes the growing amount of data supporting a role for protein glycosylation in drug resistance. The dynamic and context-dependent nature of protein glycosylation is also comprehensively discussed, hence highlighting its potentially important role as a biomarker of CSC. As the paradigm of cancer therapeutics shifts towards precision medicine and patient-tailored therapeutics, we bring into focus the need to introduce glycomics and glycoproteomics in holistic pan-omics models, in order to integrate diverse, multimodal and clinically relevant information towards more effective cancer therapeutics.This work was supported by European Union funds (FEDER/COMPETE) and by national funds (FCT, the Portuguese Foundation for Science and Technology) under the projects with the references FCOMP-01-0124-FEDER 028188 (PTDC/BBB-EBI/0786/2012) and PTDC/BBB-EBI/0567/2014. C.R. acknowledges the support by Gastric Glyco Explorer Initial Training Network (Seventh Framework Programme grant no. 316929). IPATIMUP integrates the i3S Research Unit, which is partially supported by FCT, (PEst-C/SAU/LA0003/2013). Grants were received from FCT: SFRH/BPD/111048/2015 to J.A.F and SFRH/BD/111242/2015 to A.P. FCT is co-financed by European Social Fund (ESF) under Human Potential Operation Programme (POPH) from National Strategic Reference Framework (NSRF)
Effects of a magnetic field on the one-dimensional spin-orbital model
We study the effects of a uniform magnetic field on the one-dimensional
spin-orbital model in terms of effective field theories. Two regions are
examined: one around the SU(4) point (J=K/4) and the other with K<<J. We found
that when , the spin and orbital correlation functions exhibit
power-law decay with nonuniversal exponents. In the region with J>K/4, the
excitation spectrum has a gap. When the magnetic field is beyond some critical
value, a quantum phase transition occurs. However, the correlation functions
around the SU(4) point and the region with K<<J exhibit distinct behavior. This
results from different structures of excitation spectra in both regime.Comment: 22 pages, no figure
Insulating charge density wave for a half-filled SU(N) Hubbard model with an attractive on-site interaction in one dimension
We study a one-dimensional SU(N) Hubbard model with an attractive on-site
interaction and at half-filling on the bipartite lattice using
density-matrix renormalization-group method and a perturbation theory. We find
that the ground state of the SU(N) Hubbard model is a charge density wave state
with two-fold degeneracy. All the excitations are found to be gapful, resulting
in an insulating ground state, on contrary to that in the SU(2) case. Moreover,
the charge gap is equal to the Cooperon gap, which behaves as
in the strong coupling regime. However, the spin gap and the
quasiparticle gap as well open exponentially in the weak coupling
region, while in the strong coupling region, they linearly depend on such
that and .Comment: 7 pages, 7 figure
Equilibrium Sampling From Nonequilibrium Dynamics
We present some applications of an Interacting Particle System (IPS)
methodology to the field of Molecular Dynamics. This IPS method allows several
simulations of a switched random process to keep closer to equilibrium at each
time, thanks to a selection mechanism based on the relative virtual work
induced on the system. It is therefore an efficient improvement of usual
non-equilibrium simulations, which can be used to compute canonical averages,
free energy differences, and typical transitions paths
Effect of Hund coupling in the one-dimensional SU(4) Hubbard model
The one-dimensional SU(4) Hubbard model perturbed by Hund coupling is
studied, away from half-filling, by means of renormalization group and
bosonization methods. A spectral gap is always present in the spin-orbital
sector irrespective of the magnitude of the Coulomb repulsion. We further
distinguish between two qualitatively different regimes. At small Hund
coupling, we find that the symmetry of the system is dynamically enlarged to
SU(4) at low energy with the result of {\it coherent} spin-orbital excitations.
When the charge sector is not gapped, a superconducting instability is shown to
exist. At large Hund coupling, the symmetry is no longer enlarged to SU(4) and
the excitations in the spin sector become {\it incoherent}. Furthermore, the
superconductivity can be suppressed in favor of the conventional charge density
wave state.Comment: 10 pages, 1 figur
Effect of symmetry breaking perturbations in the one-dimensional SU(4) spin-orbital model
We study the effect of symmetry breaking perturbations in the one-dimensional
SU(4) spin-orbital model. We allow the exchange in spin () and orbital
() channel to be different and thus reduce the symmetry to SU(2)
SU(2). A magnetic field along the direction is also applied. Using
the formalism developped by Azaria et al we extend their analysis of the
isotropic , h=0 case and obtain the low-energy effective theory near
the SU(4) point in the asymmetric case. An accurate analysis of the
renormalization group flow is presented with a particular emphasis on the
effect of the anisotropy. In zero magnetic field, we retrieve the same
qualitative low-energy physics than in the isotropic case. In particular, the
massless behavior found on the line extends in a large
anisotropic region. We discover though that the anisotropy plays its trick in
allowing non trivial scaling behaviors of the physical quantities. When a
magnetic field is present the effect of the anisotropy is striking. In addition
to the usual commensurate-incommensurate phase transition that occurs in the
spin sector of the theory, we find that the field may induce a second
transition of the KT type in the remaining degrees of freedom to which it does
not couple directly. In this sector, we find that the effective theory is that
of an SO(4) Gross-Neveu model with an h-dependent coupling that may change its
sign as h varies.Comment: 14 pages, 5 Figs, added referenc
Acquired resistance of human T cells to sulfasalazine: stability of the resistant phenotype and sensitivity to non-related DMARDs.
2.5 weeks) resumption of SSZ resistance and ABCG2 expression as in the original CEM/SSZ cells. CEM/SSZ cells displayed diminished sensitivity to the DMARDs leflunomide (5.1-fold) and methotrexate (1.8-fold), were moderately more sensitive (1.6-2.0 fold) to cyclosporin A and chloroquine, and markedly more sensitive (13-fold) to the glucocorticoid dexamethasone as compared with parental CEM cells. CONCLUSION: The drug efflux pump ABCG2 has a major role in conferring resistance to SSZ. The collateral sensitivity of SSZ resistant cells for some other (non-related) DMARDs may provide a further rationale for sequential mono- or combination therapies with distinct DMARDs upon decreased efficacy of SSZ
Phase diagram of a 1 dimensional spin-orbital model
We study a 1 dimensional spin-orbital model using both analytical and
numerical methods. Renormalization group calculations are performed in the
vicinity of a special integrable point in the phase diagram with SU(4)
symmetry. These indicate the existence of a gapless phase in an extended region
of the phase diagram, missed in previous studies. This phase is SU(4) invariant
at low energies apart from the presence of different velocities for spin and
orbital degrees of freedom. The phase transition into a gapped dimerized phase
is in a generalized Kosterlitz-Thouless universality class. The phase diagram
of this model is sketched using the density matrix renormalization group
technique.Comment: 11 pages, 5 figures, new references adde
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