1 research outputs found
Chlamydia pneumoniae and Helicobacter pylori IgG seropositivities are not predictors of osteoporosis‑associated bone loss: a prospective cohort study
The potential link between infection with Chlamydia
pneumoniae or Helicobacter pylori and osteoporosis
has not been investigated in population-based longitudinal
studies. A total of 250 healthy postmenopausal women
who participated in a prospective cohort study were evaluated
for IgG antibodies directed against C. pneumoniae and
H. pylori, osteoprotegerin (OPG), the receptor activator of
nuclear factor kappa B ligand (RANKL), CrossLaps, and
osteocalcin. Bone mineral density (BMD) was measured at
the femoral neck and lumbar spine at baseline and at follow-
up 5.8 years later. There were no significant differences
in age-adjusted bone turnover markers, OPG, RANKL,
the RANKL/OPG ratio, and BMD between the C. pneumoniae
and H. pylori IgG seropositive and seronegative
subjects (P > 0.05). Neither C. pneumoniae nor H. pylori
IgG seropositivity was associated with age-and body massindex-adjusted BMD at the femoral neck and lumbar spine
or bone loss at the 5.8-year follow-up. In logistic regression
analysis, neither C. pneumoniae nor H. pylori IgG seropositivities
predicted incident lumbar or spine osteoporosis
5.8 years later. In conclusion, neither C. pneumoniae nor
H. pylori IgG seropositivity was associated with bone turnover
markers, the RANKL/OPG ratio, BMD, or bone loss
in postmenopausal women. In addition, chronic infection
with C. pneumoniae or H. pylori did not predict incident
osteoporosis among this group of wome