Evolution and geochemical studies on a stromatic migmatite-amphibolite association in Hafafit area, Central Eastern Desert, Egypt

The infrastructural rocks exist in the form of the gneiss domes that constituting 7% of the surface outcrops of the basement rocks of the Eastern Desert of Egypt. This study is a closer look on the mesoscopic and microscopic characteristics and the chemical behaviour of typestromatic migmatites, associated with amphibolite bands and boudins that are exposed in the northeastern part of the Migif dome, Hafafit area. Therefore, the major oxides for the studied rocks were analyzed by using the wet chemical analysis technique, whereas the trace elements analyses were carried out by XRF technique.Microprobe analyses of the investigated minerals (amphiboles, plagioclase, biotite and muscovite) were carried out with a scanning microscope and wave length dispersive spectrometers.The paragenesis and microfabric evolution of these migmatites show that they are affected by three phases of deformation. These are associated with metamorphic differentiation, crystallization and segregation. Geochemical variation between mesosomes and leucosomes reflect original compositional variations, enhanced by metamorphic differentiation and short-range migration resulting in segregation of bands. This is followed by partial melting and in-situ formation of leucosomes. Geochemical data of the associated amphibolite show that they represent para- and ortho- amphibolites. Mineral chemistry show that hornblende of the migmatites is of ferro-tschermakitic, while from the amphibolites has magnesio-hornblende composition. Plagioclase of the amphibolite has An36-44, while of the migmatites has An25-32 in the leucosomes and An51-60 in the mesosomes and melanosomes. The amphibolites were formed at temperature ranges from 720-740ºC, whereas the migmatites at temperature ranges from 800-820ºC.The mineral chemistry support their formation in the upper amphibolite facies

Relation between migraine pattern and white matter hyperintensities in brain magnetic resonance imaging

Abstract Background Migraine is a common disorder in general population. Presence of white matter hyperintensities (WMHs) in brain MRI of migraine patients was not studied clearly. Detection of the prevalence of white matter hyperintensities in migraine patients determines its correlation with migraine severity, type and duration. Methods Cross sectional analytic study was conducted on migraine patients attending neurology clinic Suez Canal University Hospital. Sixty-five patients with migraine aged from 18 to 50 years were included. We excluded smokers and patients with hypertension, cardiac disease, diabetes mellitus, endocrine dysfunction, oncological and hematological diseases, infectious diseases, demyelinating disorders, and Alzheimer disease. Brain MRI and laboratory investigation was done for all patients. Results White matter hyperintensities were significant more frequent in migraine with aura than those without aura. According to MIGSEV scale, white matter hyperintensities were highly significantly more frequent in grade III severity than grades II and I. The number of white matter hyperintensities increases significantly with increase intensity of pain during attack. The number of white matter hyperintensities increases significantly with increase intensity of nausea, disability, tolerability during attack and age. Resistance to treatment also shows statistically significant difference in increase number of WMHs. Conclusions White matter hyperintensities are present in 43.1% of migraine patients. Age, presence of aura, nausea, disability during attack, resistance to treatment, and severity of headache and duration of migraine are considered a risk factor for development of white matter hyperintensities

Hepatic Endometriosis Mimicking Metastatic Disease: A Case Report and Review of the Literature

Endometriosis of the liver is an uncommon disease characterized by the presence of endometrial tissue in the liver. There are no pathognomonic radiological features for hepatic endometriosis and preoperative diagnosis is difficult by imaging. Most cases are diagnosed after surgery. We report atypical imaging features of hepatic endometriosis in a 61 year-old female that mimic metastatic disease to the liver. She was referred to our institution with a presumed diagnosis of metastatic neuroendocrine tumors to the liver. After imaging guided core biopsy and histologic and immunohistochemical analysis, the diagnosis of hepatic endometrial stromal proliferation was made. We review the literature and provide imaging features that may help in reaching the correct diagnosis of hepatic endometriosis

One-pot green synthesis of reduced graphene oxide decorated with β-Ni(OH)2-nanoflakes as an efficient electrochemical platform for the determination of antipsychotic drug sulpiride

International audienc

Self-assembled ruthenium decorated electrochemical platform for sensitive and selective determination of amisulpride in presence of co-administered drugs using safranin as a mediator

International audienc

Green ecofriendly electrochemical sensing platform for the sensitive determination of doxycycline

The detection of pharmaceutical compounds in extremely low concentrations remains a challenge despite recent advancements in electrochemical sensing. In this study, a green hydrothermally synthesized nickel hydroxide-graphene hybrid material was used for the point-of-care determination of the antibiotic doxycycline (DOXY), which is a promising treatment for COVID-19 and other infections. The electrochemical sensor, based on a screen-printed electrode modified with the hybrid material, was able to detect DOXY in the range of 5.1 × 10−8 to 1.0 × 10−4 M, with a low detection limit of 9.6 × 10−9 M. This approach paves the way for eco-friendly and sustainable methods of nanomaterial synthesis for electrochemical analyses, particularly in point-of-care drug monitoring, and has the potential to improve access to testing platforms

Comparison between Pathogenic <i>Streptomyces scabies</i> Isolates of Common Scab Disease

Streptomyces scabies (Thaxter) causes destructive and serious damages to many vegetable field crops, including potato. Fourteen pure isolates were obtained from naturally diseased potato tubers showing symptoms of common scab disease, collected from different localities of Sohag governorate, Egypt. All tested isolates were identified as S. scabies (Stc) according to morphological and biochemical tests. Isolate Stc 10 exhibited the highest activity of polyphenoloxidase enzyme, followed by isolate Stc 11, while isolate Stc 2 produced the lowest activity of this enzyme. Concerning the peroxidase activity, the isolates varied in their production; Stc 11 exhibited the highest activity enzyme, followed by isolate Stc 2, whereas isolate Stc 10 produced the lowest activity of enzyme. In regard with Tyrosine Amonnia Lyase (TAL) activity, isolate Stc 2 exhibited the highest activity, followed by isolate Stc 10, whereas isolate Stc 11 exhibited the lowest activity. Agarose gel electrophoresis of the PCR amplification products revealed a band representing the expected 279 bp DNA fragment in each DNA extracted from the highly pathogenic isolates Stc 10 and 11. The results demonstrated that PCR amplification of the nec1 gene could be used as a reliable marker for detecting pathogenic Streptomyces isolates on potato tubers

Non-differential interaction between isolates of Rhizoctonia solani and flax cultivars

The pathogenicity of 24 isolates of Rhizoctonia solani (7 isolates from anastomosis group AG-2 and 17 from AG-4) was evaluated on 10 flax cultivars under greenhouse conditions. Survival, plant height, and dry weight were used as criteria to evaluate pathogenicity. Analysis of variance (ANOVA) showed that the cultivar was a highly significant source of variation in all the tested parameters (P < 0.0002). Isolate was always a highly significant source of variation in all the tested parameters (P = 0.0000). Cultivar x isolate interaction was always a nonsignificant source of variation. The results of the ANOVA in the present study suggest that physiologic specialization did not occur within R. solani isolates pathogenic on flax. They also imply that resistance of the tested cultivars was only horizontal, and there were significant differences among cultivars in this type of resistance. Similarly, pathogenicity of the tested isolates was only aggressiveness, and the isolates significantly differed in this type of pathogenicity. A hierarchical cluster analysis was conducted in order to group the isolates according to disease variables measured on the tested cultivars. Cluster analysis divided the isolates into groups; however, grouping the isolates was not related to their geographic origin nor the AG.Sýkingareiginleikar 24 stofna af Rhizoctonia solani (7 stofnar af netjuðum sveppum AG-2 og 17 af AG-4) voru metnir á 10 kvæmum af hör í gróðurhúsi. Lifun, hæð plöntu og þurrefni voru notuð til að meta sýkingareiginleika. Fervikagreining (ANOVA) sýndi að kvæmi var mjög marktæk uppspretta breytileika í öllum þáttum sem skoðaðar voru (P < 0.0002). Stofn var alltaf mjög marktæk uppspretta breytileika í öllum þáttum sem skoðaðir voru (P = 0.0000). Víxlverkun á milli stofns og kvæmis var aldrei marktæk ástæða breytileika. Niðurstöður fervikagreiningarinnar benda til þess að engin lífeðlisfræðileg sérhæfing hafi átt sér stað í R. solani stofnun sem sýkja lín. Jafnframt benda niðurstöðurnar til þess að varnir kvæmanna sem prófaðir voru séu einungis byggðar á almennri mótstöðu og að það væri marktækur munur milli kvæma í þeirri gerð mótstöðu.. Jafnframt að sýkingareiginleikar stofnanna sem prófaðir voru séu eingöngu háðir sýkingarhæfni og að munur hafi verið á stofnunum hvað þetta varðar. Klasagreining skipti sveppastofnunum í hópa en þeir voru hvorki tengdir landfræðilegum uppruna né AG

Investigation of the thermal stability of the antihypertensive drug nebivolol under different conditions: Experimental and computational analysis

The thermal decomposition of the third-generation beta-blocker nebivolol (NEB) was investigated using thermogravimetric analysis (TG) under isothermal and non-isothermal environments, revealing important steadiness performance for the dispensation in the pharma manufacturing, expecting shelf life, and appropriate storing features. Kinetic analysis was carried out using Kissinger–Akahira–Sunose, Friedman, Flynn–Wall–Ozawa, and Starink methods. The analysis reveals that the activation energy estimated from the disintegration reactions via different techniques is unswerving with each other. Furthermore, the thermodynamic constraints (ΔH, ΔS, and ΔG) of the decomposition reaction were also estimated. A correlation between the mass spectrometry and thermal behavior of NEB has also been investigated. The study provides valuable stability data, expected shelf life, and optimal storing conditions that would help drug design and manufacturing. Density functional theory was also employed to study the possible thermodynamic dissociation channels of NEB