THE METABOLSIM AND TOXICITY OF RADIUM-223 IN RATS

This report covers studies of the excretion and retention of 'tracer' and toxic doses of the 11.2-day Ra{sup 223} isotope, its acute toxicity (organ weight changes, gross and microscopic pathology, and Fe{sup 59} utilization by the bone marrow), and long-term histopathological changes and alterations in the hemogram

LOCALIZATION OF CERIUM-144 IN THE SKELETAL TISSUES OF FETAL RATS

The developing fetal skeleton of the rat was used to study the microscopic localization of the rare earth Ce/sup 144/ in bone. Nineteen-day-old rat fetuses were injected with Ce/sup 144/ in isotonic sodium citrate via the umbilical vein. They were sacrificed one-haif hour after the injection by immersion in 80% alcohol fixative. The fetuses were embedded in paraffin and sectioned at 10 to 12 mu . Semiserial sections were treated with periodic acid- Schiff stain for mucopolysaccharides, and by the von Kossa technique for calcium. Contract x-ray-film autoradiographs and NTB stripping-film autoradiographs were prepared. Photographs of representative sections and their respective autoradiographs are presented for various bones. This material strongly suggests that the initial binding site of Ce/sup 44/ in the skeleton is in the organic matrix of cartilage and bone, especially where this matrix is just entering the calcifiable state. This conclusion is highly dependent upon the specificity of the von Kossa stain for calcium. (auth

THE EFFECT OF PROPYL THIOURACIL ON THE RECOVERY OF RAT THYROID GLAND FROM IRRADIATION WITH ASTATINE-211

Bibliography references : p. 21-22.Mode of access: Internet

The effect of propyl thiouracil on the recovery of rat thyroid gland from irradiation with astatine-211 /

Bibliography references : p. 21-22.Mode of access: Internet