Effects of lithium on electrical activity and potassium ion distribution in the vertebrate central nervous system

Three different regions of the vertebrate central nervous system maintained in vitro (frog spinal cord, guinea pig olfactory cortex and hippocampus) have been used to investigate how Li+ influences membrane potential, membrane resistance, action potentials, synaptic potentials and the transmembrane K+-distribution of neurons and glial cells. In view of the therapeutic action of Li+ in manicdepressive disease, a special effort was made to determine the threshold concentration for the actions of Li+ on the parameters described above. It was observed that Li+ induced a membrane depolarization of both neurons and glial cells, a decrease of action potential amplitudes, a facilitation of monosynaptic excitatory postsynaptic potentials and a depression of polysynaptic reflexes. The membrane resistance of neurons was not altered. Li+ also induced an elevation of the free extracellular potassium concentration and a decrease of the free intracellular potassium concentration. Furthermore, in the presence of Li+ a slowing of the recovery of the membrane potential of neurons and glial cells, and of the extracellular potassium concentration after repetitive synaptic stimulation was observed. The threshold concentrations for the effects of Li+ were below 5 mmol/l in the frog spinal cord and below 2 mmol/l in the guinea pig olfactory cortex and hippocampus. The basic mechanism underlying the action of Li+ may be an interaction with the transport-function of the Na+/K+ pump

Médecine d'urgence de l'adulte :attitudes et traitements

1ère édition 1er tirage Année Académique 1978-1979MEDinfo:eu-repo/semantics/published

APPROCHE CLINIQUE DES INTOXICATIONS AUX CHAMPIGNONS

Mushroom intoxication is rare in Belgium. Consequently, physicians do not know much about it. The purpose of the present article is to present a clinical approach allowing the diagnoses of the common intoxications. From the 'incubation' period, and the symptoms, it is possible to identify the toxin and to estimate the severity of the intoxication. A comprehensive treatment should follow.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Urinary hydroxylysine and hydroxylysyl glycoside excretions in normal and pathologic states

Hydroxylysyl glycoside excretion in the urine of normal subjects and of patients having either a skin or a bone disease was measured by ion exchange chromatography. Free hydroxylysine and peptide-bound hydroxylysine excretions were determined in normal and certain pathologic urines. Hydroxylysyl glycosides constitute the greatest fraction of the total hydroxylysine excretion (81 per cent). The monosaccharidic form predominates in the urine of patients with bone diseases, while the disaccharidic form is mainly excreted in skin diseases. Free hydroxylysine and peptide-bound hydroxylysine represent, respectively, 8 and 11 per cent of the total hydroxylysine excretion. Most of this latter form comes probably from large urinary polypeptides. In some diseases, smaller peptides containing hydroxylysine could be released. © 1974.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Certificat de soins intensifs, réanimation et anesthésiologie

SYL-002069 = Troisième partieTroisième partie :Principes généraux de diagnostic et de traitement des intoxications aiguësME 0544 Cinfo:eu-repo/semantics/published

La Faculté de Médecine de l'ULB pendant la guerre 1914-1918

As the German army closed the Belgian Universities, was the ULB Medicine Faculty still able to fulfil its missions ?Much has been written on Antoine Depage and the ambulance de l'Océan in La Panne so that it seems that faculty activities existed only in West Flanders in " Free Belgium ". What about Brussels during German occupation ?Actually, several famous members of this Faculty are still working, teaching, searching and publishing in the capital. Faculty itself holds sessions in 1914, 1915 and 1918. It prepares the after war medical education with the belief that Germany will be soon defeated.SCOPUS: re.jinfo:eu-repo/semantics/publishe

Courrier des lecteurs: Commentaires relatifs à l'article sur la prise en charge des insomnies

SCOPUS: le.jinfo:eu-repo/semantics/publishe

Etude du métabolisme du collagène par l'excrétion urinaire des glycosides de l'hydroxylysine

Doctorat en sciences médicalesL'année de défense de cette thèse est incertaineinfo:eu-repo/semantics/nonPublishe

INFRASTRUCTURE HOSPITALIERE DE L'URGENCE EN BELGIQUE

SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

Les trois carabins: roman

Préfaces d'Elie Cogan et de Jean-Louis Vanherwegheminfo:eu-repo/semantics/publishe