Normalized gene expression of <i>LDLR</i> gene in healthy controls, aPLA+, aPLA+/th- and aPLA+/th+ individuals.

<p>Two asterisks denote statistically significant differences between case and controls (<i>P</i>-value < 0.0001).</p

Characteristics of individuals included in the study.

<p>Characteristics of individuals included in the study.</p

Candidate genes included in the study.

<p>Candidate genes included in the study.</p

Variance in mAO for each CAGexp allele (40–44 range) in normotensives and in pre-HD AHT patients.

<p>Numbers above the square brackets are the difference in median years between Pre-HD AHT and normotensives for each CAGexp allele.</p

Multiple regression analyses and descriptive statistics for mAO.

<p>Multiple regression analyses and descriptive statistics for mAO.</p

RT-qPCR analysis of <i>E2F2</i> gene expression in HD patients, according to <i>E2F2</i> rs2742976 genotype.

<p>Two methods were used. In Taqman assay, the expression of <i>E2F2</i> gene was analyzed in 31 samples (N _TT = 4; N _GT = 12, N _GG = 15) with Hs00918089_m1 Taqman probe; the expression values were normalized respect to expression of <i>B2M</i> and <i>YWHAZ</i> reference genes. In SYBR Green assay, the <i>E2F2</i> gene expression was estimated in 31 samples (N_TT = 5; N_GT = 14, N_GG = 12); the expression values were normalized to expression of <i>UBC</i> and <i>YWHAZ</i> reference genes. Results are expressed as fold over respective GG individuals. Asterisk denotes statistically significant differences (P<0.05) between GG and any other group, according to DataAssist software analysis (T-test) or REST software analysis (Pair Wise Reallocation Randomization test).</p

CAGexp and mAO comparisons between samples from Southern and Northern European populations.

<p>CAGexp and mAO comparisons between samples from Southern and Northern European populations.</p

CAGexp and eAO comparisons between samples from Southern and Northern European populations.

<p>CAGexp and eAO comparisons between samples from Southern and Northern European populations.</p