1,530 research outputs found
Carbon Deficiency in Externally-Polluted White Dwarfs: Evidence for Accretion of Asteroids
Existing determinations show that n(C)/n(Fe) is more than a factor of 10
below solar in the atmospheres of three white dwarfs that appear to be
externally-polluted. These results are not easily explained if the stars have
accreted interstellar matter, and we re-interpret these measurements as
evidence that these stars have accreted asteroids of a chrondritic composition.Comment: 23 pages, 6 figures, accepted for Ap
Activation of the Lck Tyrosine Kinase Targets Cell Surface T Cell Antigen Receptors for Lysosomal Degradation
AbstractThe mechanism by which TCR expression is regulated was explored by expressing a constitutively active form of the tyrosine kinase Lck (Lck505F) in T cells. Expression of Lck505F down-regulated TCR levels, an effect that was even more pronounced in CD45− T cells, in which the activity of this tyrosine kinase is further enhanced. Cells expressing Lck505F synthesized all TCR subunits, but lysosomal degradation of assembled receptors was enhanced. TCRs were rapidly internalized and degraded after removal of a tyrosine kinase inhibitor that had permitted cell surface expression. Finally, TCR levels on thymocytes were increased by an Lck inhibitor, and activation- but not phorbol ester–induced internalization of TCRs on Jurkat cells was prevented by inhibition or loss of Lck. These studies identify a regulated nonreceptor tyrosine kinase–mediated pathway for targeting cell surface receptors for lysosomal degradation
Optical second harmonic generation probe of two-dimensional ferroelectricity
Optical second harmonic generation (SHG) is used as a noninvasive probe of
two-dimensional (2D) ferroelectricity in Langmuir-Blodgett (LB) films of
copolymer vinylidene fluoride with trifluorethylene. The surface 2D
ferroelectric-paraelectric phase transition in the topmost layer of LB films
and a thickness independent (almost 2D) transition in the bulk of these films
are observed in temperature studies of SHG.Comment: 9 pages, 2 figures, Optics Letters, in prin
Vaccine Hesitancy and Support for Employer Vaccine Mandates
This study investigated COVID-19 vaccine hesitancy and support for employer vaccine mandates and support for termination for non-vaccinated employees among a national sample in New Zealand. A total of 1852 individuals participated in the study. Results indicated participants who are able to get vaccinated are less likely to support employer mandated vaccinations and the rights of employers to terminate employees who refuse to get vaccinated. However, individuals who self-identify that they can get vaccinated and have higher confidence in the COVID-19 vaccine are more likely to get vaccinated. Age and confidence in the vaccine influence support for mandates, while age and political affiliation influenced support for employer right to terminate a non-vaccinated employee. Understanding support, or lack thereof, for such initiatives is essential as businesses and nations respond to growing COVID concerns.fals
Subunit interactions within the T-cell antigen receptor: clues from the study of partial complexes.
Formation of Structure in Snowfields: Penitentes, Suncups, and Dirt Cones
Penitentes and suncups are structures formed as snow melts, typically high in
the mountains. When the snow is dirty, dirt cones and other structures can form
instead. Building on previous field observations and experiments, this work
presents a theory of ablation morphologies, and the role of surface dirt in
determining the structures formed. The glaciological literature indicates that
sunlight, heating from air, and dirt all play a role in the formation of
structure on an ablating snow surface. The present work formulates a
mathematical model for the formation of ablation morphologies as a function of
measurable parameters. The dependence of ablation morphologies on weather
conditions and initial dirt thickness are studied, focusing on the initial
growth of perturbations away from a flat surface. We derive a single-parameter
expression for the melting rate as a function of dirt thickness, which agrees
well with a set of measurements by Driedger. An interesting result is the
prediction of a dirt-induced travelling instability for a range of parameters.Comment: 28 pages, 13 figure
Properties of Ridges in Elastic Membranes
When a thin elastic sheet is confined to a region much smaller than its size
the morphology of the resulting crumpled membrane is a network of straight
ridges or folds that meet at sharp vertices. A virial theorem predicts the
ratio of the total bending and stretching energies of a ridge. Small strains
and curvatures persist far away from the ridge. We discuss several kinds of
perturbations that distinguish a ridge in a crumpled sheet from an isolated
ridge studied earlier (A. E. Lobkovsky, Phys. Rev. E. 53 3750 (1996)). Linear
response as well as buckling properties are investigated. We find that quite
generally, the energy of a ridge can change by no more than a finite fraction
before it buckles.Comment: 13 pages, RevTeX, acknowledgement adde
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