968 research outputs found

    Status of Using Quantitative Methods in Project Risk Management

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    This study aims to evaluate the current project risk management within UNRWA in Gaza in all areas related to the Agency’s mandate. Projects implemented by UNRWA in Gaza are subject to risks due to the volatile situation and the adverse situation representing risks and uncertainties that are difficult to predict and that impede the effective and timely implementation of projects according to their plans. This negatively impacts the outputs of these projects and creates grave repercussions and disruption consuming the project resources and budgets. This will also have a negative impact on the Agency’s image and funding as the relationship with the donor community will be also distorted

    Preparation and Comparative Evaluation of Fe+2/Fe+3 and Mg+2/Fe+3 LDHs as Promising Nanocarriers for Class II and Class IV Drugs

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    Application of NPs is a promising nanocarriers strategy for development of new drug delivery system. To accomplish such strategy, two types of NPs of layered double hydroxides (Fe+2/Fe+3) and (Mg+2/Fe+3) were synthesized, each one was separately loaded with two types of drugs, montelukast sodium (class II) and cefdinir (class IV) by application of two methods of drug loading (ion-exchange and intercalation methods). The final dried powder were characterized using Fourier transform infrared spectra (FT-IR), Scanning electron microscopy (SEM), Transmission Electron Microscopy (TEM), Thermal analysis (TGA), Zeta Potential analyzer, Powder X-ray diffraction pattern (PXRD) and Energy-dispersive X-ray spectroscopy (EDX), and evaluated by measuring solubility, percentage yield and drug loading capacity, in vitro dissolution, in vitro diffusion and biological activity. The results indicated that Fe+2/Fe+3 LDHs NPs is more suitable nanocarrier for class IV as well as class II drugs since it gave smaller particle size, improved permeability, higher loading capacity and improved biological activity therefore, it could be used to give sustained release pattern that can prolong the action of the drug in the body. Keywords: Fe+2/Fe+3-LDHs, Mg+2/Fe+3-LDHs, drug loading, cefdinir, montelukas

    High Studies Deanery Faculty of Commerce Business Administration Department

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    This study aimed to show the influence of information overload on the decision making process, using the descriptive analytical method to study the influence of information overload represented through three dimensions (email overload, information characteristics and information & communication technology). The study was applied on INGOs that work in Gaza Strip. The questionnaire was used as a data collection tool. The study population was (106) who are all managers (Top and Middle levels Management) in INGOs. A census has been used for the target population. Because of the policy of some organizations regarding confidentiality and privacy of work environment, only (86) questionnaires were collected and all were retrieved and analyzed. Results of the analysis of the questionnaire data demonstrate significant relationship of information overload with the managers ‘decision making process

    THE USE OF SIMULATION TO EVALUATE AND ENHANCE THE PERFORMANCE OF PASSPORTS AND CIVIL AFFAIRS SECTOR

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    In this thesis, the proposed project intends to study the use of Decision Support Systems in simulating Gaza Civil Affairs and Passports Directorate (GCAPD) through identifying the current environment, analyzing the status, and proposing a new system using simulation to determine the optimal number of service providers for the system in order to reduce the postponement of the public services

    LOADING OF CLARITHROMYCIN AND PACLITAXEL ON SYNTHESIZED CdS/NiO NANOPARTICLES AS PROMISING NANOCARRIERS

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    Objective: In this study cadmium sulfide (CdS) and nickel oxide (NiO) nanoparticles were synthesized and applied as novel nanocarriers for antibacterial drug clarithromycin (CLA) and anticancer drug paclitaxel (PTX) to improve their physical properties and biological activities.Methods: Cadmium sulfide (CdS) and nickel oxide (NiO) nanoparticles were synthesized by chemical co-precipitation and thermochemical processing techniques respectively and loaded with clarithromycin (CLA) and paclitaxel (PTX) by simple new one-step reaction. Analytical measures including FTIR, PXRD, SEM, AFM, TGA, DSC and zeta potential where used for characterization. The in vitro release, antibacterial as well as anticancer activities were evaluated.Results: Analytical measures revealed that the loading involved physical complex formation rather than chemical modification with the high percent surface loading of the drugs on the nanoparticles. Solubility/dissolution study revealed higher significant* improvement in the solubility of CLA from NiO nanoparticles than that from CdS nanoparticles while the antibacterial activity of CLA was non-significantly improved. For PTX loaded on CdS and NiO nanoparticles showed non-significant change in its solubility, but remarkable significant* increase in its antitumor activity on MCF-7 cell line accompanied with significant* reduction in its cytotoxicity on normal mammary cell line (MCF-10A) indicating the selectivity and targeting of PTX-CdS/NiO nanocarriers with reduced side effects of the drug and the used metal nanocarriers.Conclusion: This work provided most selective and safe delivery system for PTX and best method for enhancement of CLA solubility.Keywords: Clarithromycin (CLA), Paclitaxel (PTX), Cadmium sulfide (CdS) nanoparticles, Nickel oxide (NiO) nanoparticlesÂ
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