1 research outputs found
Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries
From a screening campaign that included
mixture-based libraries containing more than 6 million compounds,
a lead series of bis-cyclic guanidines was identified as the most
promising. Lead optimization resulted in the identification of potent
(IC<sub>50</sub> < 500 nM) and selective compounds within this
series as well as potent and selective monoguanidines