Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain-0

<p><b>Copyright information:</b></p><p>Taken from "Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain"</p><p>http://www.biomedcentral.com/1471-2202/9/12</p><p>BMC Neuroscience 2008;9():12-12.</p><p>Published online 24 Jan 2008</p><p>PMCID:PMC2245968.</p><p></p>IMI), desipramine (DES), fluoxetine (FLU), paroxetine (PAR), maprotiline (MAP), or nomifensine (NOM). After 90 min, tissue contents of [H]CDP-diacylglycerol were assayed. Each bar is the mean ± SEM (N = 9). Each drug stimulated significant concentration-dependent accumulations of CDP-diacylglycerol (ANOVA, p < 0.001 for each drug). Based on Dunnett tests, all agents induced statistically significant CDP-diacylglycerol responses at the 3 or 10 μM concentrations, except for paroxetine in the hippocampus and imipramine in the striatum where the drug effects were not significant until the 30 μM and higher concentrations

Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain-6

<p><b>Copyright information:</b></p><p>Taken from "Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain"</p><p>http://www.biomedcentral.com/1471-2202/9/12</p><p>BMC Neuroscience 2008;9():12-12.</p><p>Published online 24 Jan 2008</p><p>PMCID:PMC2245968.</p><p></p>oncentrations of fluoxetine or imipramine were added, and after 60 min accumulated [H]CDP-diacylglycerol was measured. While the frontal cortex data are shown, similar observations were made in the hippocampus. Each bar is the mean ± SEM (= 6). The presence of LiCl did not significantly alter the stimulatory effects of fluoxetine or imipramine on [H]DCP- diacylglycerol accumulation (ANOVA, p > 0.05)

Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain-1

<p><b>Copyright information:</b></p><p>Taken from "Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain"</p><p>http://www.biomedcentral.com/1471-2202/9/12</p><p>BMC Neuroscience 2008;9():12-12.</p><p>Published online 24 Jan 2008</p><p>PMCID:PMC2245968.</p><p></p>IMI), desipramine (DES), fluoxetine (FLU), paroxetine (PAR), or maprotiline (MAP). After 90 min, [H]inositol phospholipids were extracted and assayed as a total pool of extractable phosphatidylinositides. Each bar is the mean ± SEM (N = 9). Each drug stimulated significant and concentration-dependent increases in [H]inositol phospholipid synthesis (ANOVA, p < 0.001 for each drug). From the subsequent Dunnett tests, all agents induced statistically significant CDP-diacylglycerol responses at the 3 or 10 μM and higher concentrations