Reclaiming human machine nature

Extending and modifying his domain of life by artifact production is one of the main characteristics of humankind. From the first hominid, who used a wood stick or a stone for extending his upper limbs and augmenting his gesture strength, to current systems engineers who used technologies for augmenting human cognition, perception and action, extending human body capabilities remains a big issue. From more than fifty years cybernetics, computer and cognitive sciences have imposed only one reductionist model of human machine systems: cognitive systems. Inspired by philosophy, behaviorist psychology and the information treatment metaphor, the cognitive system paradigm requires a function view and a functional analysis in human systems design process. According that design approach, human have been reduced to his metaphysical and functional properties in a new dualism. Human body requirements have been left to physical ergonomics or "physiology". With multidisciplinary convergence, the issues of "human-machine" systems and "human artifacts" evolve. The loss of biological and social boundaries between human organisms and interactive and informational physical artifact questions the current engineering methods and ergonomic design of cognitive systems. New developpment of human machine systems for intensive care, human space activities or bio-engineering sytems requires grounding human systems design on a renewed epistemological framework for future human systems model and evidence based "bio-engineering". In that context, reclaiming human factors, augmented human and human machine nature is a necessityComment: Published in HCI International 2014, Heraklion : Greece (2014

Two Amino Acid Residues Contribute to a Cation-π Binding Interaction in the Binding Site of an Insect GABA Receptor

Cys-loop receptor binding sites characteristically possess an "aromatic box," where several aromatic amino acid residues surround the bound ligand. A cation-π interaction between one of these residues and the natural agonist is common, although the residue type and location are not conserved. Even in the closely related vertebrate GABA_A and GABA_C receptors, residues in distinct locations perform this role: in GABA_A receptors, a Tyr residue in loop A forms a cation-π interaction with GABA, while in GABA_C receptors it is a loop B residue. GABA-activated Cys-loop receptors also exist in invertebrates, where they have distinct pharmacologies and are the target of a range of pesticides. Here we examine the location of GABA in an insect binding site by incorporating a series of fluorinated Phe derivatives into the receptor binding pocket using unnatural amino acid mutagenesis, and evaluating the resulting receptors when expressed in Xenopus oocytes. A homology model suggests that two aromatic residues (in loops B and C) are positioned such that they could contribute to a cation-π interaction with the primary ammonium of GABA, and the data reveal a clear correlation between the GABA EC_(50) and the cation-π binding ability both at Phe206 (loop B) and Tyr254 (loop C), demonstrating for the first time the contribution of two aromatic residues to a cation-π interaction in a Cys-loop receptor

Quantifying Self-Organization with Optimal Predictors

Despite broad interest in self-organizing systems, there are few quantitative, experimentally-applicable criteria for self-organization. The existing criteria all give counter-intuitive results for important cases. In this Letter, we propose a new criterion, namely an internally-generated increase in the statistical complexity, the amount of information required for optimal prediction of the system's dynamics. We precisely define this complexity for spatially-extended dynamical systems, using the probabilistic ideas of mutual information and minimal sufficient statistics. This leads to a general method for predicting such systems, and a simple algorithm for estimating statistical complexity. The results of applying this algorithm to a class of models of excitable media (cyclic cellular automata) strongly support our proposal.Comment: Four pages, two color figure

The Active Nucleus of IC4970: A Nearby Example of Merger-Induced Cold-Gas Accretion

We present results from Chandra X-ray and Spitzer mid-infrared observations of the interacting galaxy pair NGC6872/IC4970 in the Pavo galaxy group and show that the smaller companion galaxy IC4970 hosts a highly obscured active galactic nucleus (AGN). The 0.5-10 keV X-ray luminosity of the nucleus is variable, increasing by a factor 2.9 to 1.7 x 10^{42} erg/s (bright state) on ~100 ks timescales. The X-ray spectrum of the is heavily absorbed (N_H = 3 x 10^{23} cm^{-2}) for power law models with Gamma = 1.5-2.0 and shows a clear 6.4 keV Fe Kalpha line with equivalent width of 144-195 eV. Limits on the diffuse emission in IC4970 from Chandra X-ray data suggest that the available power from Bondi accretion of hot interstellar gas may be an order of magnitude too small to power the AGN. Spitzer images show that 8 micron nonstellar emission is concentrated in the central 1 kpc of IC4970, consistent with high obscuration in this region. The mid-infrared colors of the nucleus are consistent with those expected for a highly obscured AGN. Taken together these data suggest that the nucleus of IC4970 is a Seyfert 2, triggered and fueled by cold material supplied to the central supermassive black hole as a result of the off-axis collision of IC4970 with the cold-gas rich spiral galaxy NGC6872.Comment: 10 pages, 9 figures, submitted to ApJ, MIR flux conversion error corrected in Table 4, MIR colors and paper text unchange

Mid-infrared Identification of 6 cm Radio Source Counterparts in the Extended Groth Strip

A new 6-cm survey of almost 0.6 square degrees to a limit of 0.55-mJy/beam (10-sigma) finds 37 isolated radio sources and 7 radio source pairs (not necessarily physical companions). IRAC counterparts are identified for at least 92% of the radio sources within the area of deep IRAC coverage, which includes 31 isolated sources and 6 pairs. This contrasts with an identification rate of <74% to R<23.95 in visible light. Eight of the IRAC galaxies have power law spectral energy distributions, implying that the mid-infrared emission comes from a powerful AGN. The remaining 26 IRAC galaxies show stellar emission in the mid-infrared, probably in most of these galaxies because the stellar emission is bright enough to outshine an underlying AGN. The infrared colors suggest that the majority of these galaxies are bulge-dominated and have redshifts between approximately 0.5 and 1.0. Visible spectra from the DEEP2 redshift survey, available for 11 galaxies, are consistent with this suggestion. The IRAC galaxies fall into two distinct groups in a color-magnitude diagram, one group (the "stripe") includes all the AGN. The other group (the "blue clump") has blue 3.6 to 8 micron colors and a small range of 8 micron magnitudes. This separation should be useful in classifying galaxies found in other radio surveys.Comment: Accepted by A

Star formation in z>1 3CR host galaxies as seen by Herschel

We present Herschel (PACS and SPIRE) far-infrared (FIR) photometry of a complete sample of z>1 3CR sources, from the Herschel GT project The Herschel Legacy of distant radio-loud AGN (PI: Barthel). Combining these with existing Spitzer photometric data, we perform an infrared (IR) spectral energy distribution (SED) analysis of these landmark objects in extragalactic research to study the star formation in the hosts of some of the brightest active galactic nuclei (AGN) known at any epoch. Accounting for the contribution from an AGN-powered warm dust component to the IR SED, about 40% of our objects undergo episodes of prodigious, ULIRG-strength star formation, with rates of hundreds of solar masses per year, coeval with the growth of the central supermassive black hole. Median SEDs imply that the quasar and radio galaxy hosts have similar FIR properties, in agreement with the orientation-based unification for radio-loud AGN. The star-forming properties of the AGN hosts are similar to those of the general population of equally massive non-AGN galaxies at comparable redshifts, thus there is no strong evidence of universal quenching of star formation (negative feedback) within this sample. Massive galaxies at high redshift may be forming stars prodigiously, regardless of whether their supermassive black holes are accreting or not.Comment: 30 pages, 13 figures, 4 tables. Accepted for publication in A&