Pengaruh Latihan Sirkuit Terhadap Daya Tahan Pada Tim Sepakbola SMKN 5 Pekanbaru

The problem in this study came from the interim results of observation carried out by researchers in the field. Researchers found the problem is the lack of durability that is owned by the football team SMKN 5 Pekanbaru. The purpose of this study was to determine the effect on the endurance circuit training on the football team SMKN 5 Pekanbaru. The study used the approach of one-group pretest-posttest design. The population in this study is a soccer player who SMKN Pekanbaru 5 of 16 people by using total sampling where all population sampled, to obtain research data using preliminary tests pretest and post-test after it was given a circuit workout. Diproleh The data were analyzed using t-test. Based on data analysis found that a circuit workout effect on durability on the football team SMKN 5 Pekanbaru, marked from the results diproleh namely 2,595 tcount > rtable 1,753. From the results obtainable circuit training effect on the durability of the soccer team SMKN 5 Pekanbaru

Aktivitas Sitotoksik Ekstrak Etanolik Herba Ciplukan (Physalis Angulata L.) pada Sel Kanker Leher Rahim Hela melalui Modulasi Ekspresi Protein P53

Cervical cancer is one of leading cause of cancer death in women in the developing countries. One of the strategy to prevent cervical cancer based on cytotoxic agents are now being developed. Ciplukan (Physalis angulata L.) is one of potential plant as chemopreventive agent due to Physalin and Withangulatin constituent in this plant. This study was aimed to know cytotoxic effect of ciplukan ethanolic extract (CEE) in human cervical carcinoma Hela cell line. Evaluation of cell viability value was determined using MTT assay. The expression of p53 as cell proliferation regulator was observed with immunocytochemistry assay. Ethanolic extract of ciplukan showed cytotoxic effect in HeLa cell line with IC50 of 158 µg/ml. Further observation of cell proliferation regulator showed that CEE induces expression of p53 that inhibit cell proliferation. The result showed that CEE has potential activity to be developed as anticancer agent in human cervical cancer