Simple and Efficient Synthesis of 5-Substituted-3-phenyl-2-thioxoimidazolidin-4-one Derivatives from <i>S</i>-Amino Acids and Phenylisothiocyanate in Et₃N/DMF-H₂O

<div><p></p><p>A concise approach for the transformation of various <i>S</i>-amino acids into the 5-alkyl-3-phenyl-2-thioxoimidazolidin-4-one heterocycles using phenylisothiocyanate is described. Phenylthiohydantoins of amino acid were synthesized at room temperature in Et₃N/DMF-H₂O with easy workup and excellent yields.</p></div

Meet the Board of ChemistryOpen: Sheshanath V. Bhosale

Abstract Sheshanath V. Bhosale received his PhD from Freie University Berlin (Germany) in supramolecular chemistry under the supervision of Prof. J. H. Fuhrhop in 2004. He then pursued his postdoctoral studies with Prof. S. Matile at University of Geneva (Switzerland) under the auspices of a Roche Foundation Fellowship. This was followed by a stay at Monash University (Australia) for 5 years as an ARC‐APD Fellow. He worked at RMIT University, Melbourne (Australia) for 6 years as ARC‐Future Fellowship. Currently, Prof. Bhosale is working at the Department of Chemistry, Goa University (India) as a UGC‐FRP Professor, His research interests lie in the design and synthesis of π‐functional materials, especially small molecules, for sensing, biomaterials, and supramolecular chemistry applications. So far, Prof. Bhosale has produced 185 research articles and his work has been cited more than 4400 times, giving him an h‐index of 32. He currently serves as an active Editorial Board member for ChemistryOpen

Green Process Development for the Synthesis of Aliphatic Symmetrical <i>N,N</i>′-Disubstituted Thiourea Derivatives in Aqueous Medium

<div><p>GRAPHICAL ABSTRACT</p><p></p></div

Highly Efficient Regioselective Synthesis of 2‑Imino-4-oxothiazolidin-5-ylidene Acetates via a Substitution-Dependent Cyclization Sequence under Catalyst-Free Conditions at Ambient Temperature

A green and efficient method for the synthesis of newer 2-imino-4-oxothiazolidin-5-ylidene acetate derivatives under catalyst-free conditions by simply stirring symmetrical and unsymmetrical 1,3-diarylthioureas with dialkyl acetylenedicarboxylates in ethanol at room temperature has been developed. Interestingly, the regioselective synthesis affords the 2-imino-4-oxothiazolidin-5-ylidene acetate derivatives: the amine nitrogen bonded to an electron-withdrawing substituent becomes part of the imino component, and the amine nitrogen bonded to an electron-donating substituent becomes the heterocyclic nitrogen. This is the first report wherein the impact of substituents in directing the regiocyclization has been explained and the structure conflict resolved by single-crystal X-ray analysis