8 research outputs found

    Cognitive and Metacognitive Strategies Teaching: Effects on ICT Application

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    ABSTRACT The purpose of the present study was to compare the effectiveness of cognitive and metacognitive strategies teaching on the amount of using ICT among Payam Noor university of Ardabil province. The research hypotheses were as follow: cognitive strategies instruction has an influence on the value of using information communication and technology, ICT; and metacognitive strategies teaching exerts an effect on the value of using ICT. Sixty participants who were randomly selected and divided into three conditions of cognitive, metacognitive and control group, involved the entire students (both men and women) of Payam Noor university of Ardabil province, Iran. The design of the study was quasai expermental multigroup pretest and posttest. The instrument applied was a researcher made test which was composed of seven ICDL skills. First all three groups were given a pretest then were trained some cognitive and metacognitive strategies ending up with a posttest. ANOVA and ANCOVA statistical tools were used to analyze the data. Results indicated a meaningful relationship between cognitive strategy teaching and the students' application of information technology and communication. There was no meaningful relationship between metacognitive strategy teaching and the application of information technology and communication. No remarkable difference was seen between the results of pretest and posttest of control group

    A Precise Mathematical Correlation to Estimate Product Yield of Delayed Coking Units

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    Typical models are employed to estimate the product yields of delayed coking units using complicated and multistep calculations. In current study, a new first-order mathematical model have been proposed to estimate delayed coking products yield utilizing the Volk’s model as the baseline. The modified coefficients of Volk's model for industrial level are 0.634, 0.589, 1, and 1.116 for gas, gasoline, gasoil, and coke yield prediction, respectively. In Compare to other models, the proposed model showed very close and similar trend with industrial data in yield prediction, and the average error for gas production was 0.25%. For the gasoline, almost all of the other models have overestimated efficiency. However, current model prediction was obtained close to the industrial data with average error of 14 % that is almost three times better than the Volk’s model prediction (which was the most accurate model previously). The industrial data for the gasoil was underestimated by all previous models. However, the average error of proposed model for prediction of gasoil yield was 13% while other models’ estimation error is much higher. For the coke production, this newly developed model is the most accurate one compared to other predictive models

    Dysregulation of vitamin D synthesis pathway genes in colorectal cancer: A case-control study

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    Background: The cytochromes P450 are a superfamily of enzymes that control the synthesis of the biologically active form of vitamin D, 1,25-dihydroxyvitamin D3. These enzymes contribute to the formation of 1,25-dihydroxyvitamin D3, which starts with a 25-hydroxylation by CYP2R1 and CYP27A1 and a subsequent 1α-hydroxylation via CYP27B1. Methods: By using quantitative real-time polymerase chain reaction (qRT-PCR), we analyzed the expression ratio of CYP2R1, CYP27A1 and CYP27B1 genes within the vitamin D metabolic pathway in a total of 75 colorectal cancer (CRC) tissues compared to the adjacent tissues. Furthermore, we evaluated the association of CYP27B1 rs4646536 and CYP2R1 rs12794714 and rs10766196 polymorphisms with CRC risk in a total of 490 subjects, including 245 CRC patients and 245 non-cancer controls. The genotyping was performed using tetra-primer amplification refractory mutation system polymerase chain reaction (TP-ARMS�PCR) method. Results: The results indicated 2.3 and 2.7 upregulation of CYP2R1 and CYP27B1 genes in colorectal cancer tissues compared to the adjacent tissues, respectively. Rs12794714 AG genotype increased the risk of CRC (P =.03). Furthermore, a significant association was observed under the dominant inheritance model (P =.039). Conclusion: CYP2R1 and CYP27B1 genes were over-expressed in CRC samples compared to the adjacent control tissues. Furthermore, CYP2R1 rs12794714 variant was associated with the risk of CRC in the studied samples. CYP2R1 rs10766196 and CYP27B1 rs4646536 are not responsible for CYP2R1 and CYP27B1 genes expression alteration, respectively, but CYP2R1 rs12794714 polymorphism may be the reason of CYP2R1 upregulation and increased the risk of CRC

    Dysregulation of vitamin D synthesis pathway genes in colorectal cancer: A case-control study

    Get PDF
    Background: The cytochromes P450 are a superfamily of enzymes that control the synthesis of the biologically active form of vitamin D, 1,25-dihydroxyvitamin D3. These enzymes contribute to the formation of 1,25-dihydroxyvitamin D3, which starts with a 25-hydroxylation by CYP2R1 and CYP27A1 and a subsequent 1α-hydroxylation via CYP27B1. Methods: By using quantitative real-time polymerase chain reaction (qRT-PCR), we analyzed the expression ratio of CYP2R1, CYP27A1 and CYP27B1 genes within the vitamin D metabolic pathway in a total of 75 colorectal cancer (CRC) tissues compared to the adjacent tissues. Furthermore, we evaluated the association of CYP27B1 rs4646536 and CYP2R1 rs12794714 and rs10766196 polymorphisms with CRC risk in a total of 490 subjects, including 245 CRC patients and 245 non-cancer controls. The genotyping was performed using tetra-primer amplification refractory mutation system polymerase chain reaction (TP-ARMS�PCR) method. Results: The results indicated 2.3 and 2.7 upregulation of CYP2R1 and CYP27B1 genes in colorectal cancer tissues compared to the adjacent tissues, respectively. Rs12794714 AG genotype increased the risk of CRC (P =.03). Furthermore, a significant association was observed under the dominant inheritance model (P =.039). Conclusion: CYP2R1 and CYP27B1 genes were over-expressed in CRC samples compared to the adjacent control tissues. Furthermore, CYP2R1 rs12794714 variant was associated with the risk of CRC in the studied samples. CYP2R1 rs10766196 and CYP27B1 rs4646536 are not responsible for CYP2R1 and CYP27B1 genes expression alteration, respectively, but CYP2R1 rs12794714 polymorphism may be the reason of CYP2R1 upregulation and increased the risk of CRC

    Quality of diabetes care and its consequences in Northern Iran

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    Background. Diabetes is an important public health problem. This study aimed to investigate the quality of care in patients with diabetes type 2 and its consequences in rural areas at Golestan province, North of Iran, in comparison to standards of the Ministry of Health and Education of Iran and the American Diabetes Association.   Methods. This was a cross-sectional study based on data from 308 patients with diabetes type 2 in rural areas at Golestan province, which was conducted through a two-stage classified sampling method and random selection. Data of this research was gathered through a questionnaire (fulfilled by the interviewer), assessment blood sugar, and information obtained from patients’ files. Data were analyzed by descriptive statistics and SPSS version19.   Results. The mean age of patients was 57 years and 88 patients (29%) were male. Only 35% of patients were visited seasonally by a family physician. In addition, only 24% of patients were visited at least once a year by an ophthalmologist, and 31% of patients underwent a glycated hemoglobin test at least twice a year. Influenza and hepatitis vaccines were given to 1.6% and 9.4% of patients, respectively. 85% of patients were evaluated once a year for lipid profile and 61% for creatine and albumin. Only 31% of patients received nutrition counseling at least once a year. Controlled glycated hemoglobin (HBA1c) was 27% and most patients were in the range of overweight and obesity (> 75%).   Conclusion. The findings of this study showed that the quality of diabetes care and its consequences in patients is not desirable and is far from the standards provided by the Iran’s Ministry of Health and the American Diabetes Association and requires revision in the current program of diabetes control
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