Mucocutaneous Findings in Behçet’s Disease

Behçet’s disease is a chronic inflammatory disease with an unpredictable course. The disease may affect almost all organ systems resulting with significant organ-threatening morbidity and mortality. Mucocutaneous lesions mostly constitute the initial symptoms of the disease and precede other manifestations. As there is yet no pathognomonic diagnostic test in Behçet’s disease, the recognition of cutaneous and mucosal findings let the physician enable an earlier diagnosis and earlier treatment. Therefore, the purpose of this chapter is to emphasize the importance of the mucocutaneous manifestations of Behçet’s disease and to review the mucocutaneous lesions in detail. Finally, childhood Behçet’s disease, differential diagnosis and treatment of mucocutaneous manifestations will be briefly reviewed

Pemphigus: Subtypes, Clinical Features, Diagnosis, and Treatment

Pemphigus is a group of autoimmune blistering disorders associated with autoantibodies against the keratinocyte cell surface. Pemphigus has three major variants: pemphigus vulgaris (PV), pemphigus foliaceus (PF), and paraneoplastic pemphigus (PNP) which all have further subtypes. The variants of pemphigus are classified depending upon the clinical and histological features, immunofluorescence staining pattern, and autoantibody profile of the disease. The onset and course of pemphigus appear on the basis of interaction between genetic predisposition and various triggering factors. Pemphigus vulgaris is the most commonly seen and representative clinical form of pemphigus. Together with clinical manifestations, the histopathological and immunopathological data support the diagnosis. As though some pemphigus variants, particularly pemphigus vulgaris and paraneoplastic pemphigus, have a mortality risk, early diagnosis is necessary and onset of treatment should be promptly initiated. In this chapter, firstly, classification of pemphigus is described. After then, clinical features, histopathological and immunopathological findings, target antigens, etiopathogenesis and comorbidities of each pemphigus variant are discussed briefly

A Case of an Uncombable Hair Syndrome

A 24-year-old boy applied for his nevuses. On dermatological examination, he was noticed to have glistening, rough, dry and frizzy hair which was learnt to be present since his born.  He has not applied to a doctor for his hair previously. His hair samples were examined either by light microscopy and dermoscopy. The changes were also confirmed by electron microscopy. The patient was diagnosed as uncombable hair syndrome (UHS) and was detected to have bilateral juvenile cataract.In this report, we want to emphasize the features of a rare case of UHS and look at to the methods for the the diagnosis of hair disorders.</p

Analysis of diclofenac in water samples using in situ derivatization-vortex-assisted liquid-liquid microextraction with gas chromatography-mass spectrometry

A novel micro-extraction technique for a rapid and sensitive analysis of diclofenac (DCF) in water samples has been developed. DCF was derivatized and extracted simultaneously using vortex-assisted liquid-liquid micro-extraction (VALLME) prior to gas chromatography with mass spectrometry detection. The effects of extraction solvent volume, extraction and derivatization time and ionic strength of the sample were studied using 23 factorial experimental design. The optimum extraction conditions were as follows: 200 µL of chloroform, 25 µL of N-methyl-N-trimethylsilyl-trifluoroacetamide (MSTFA) derivatization reagent, vortex extraction and derivatization time 5 min at 3000 rpm. The extraction recovery for different fortification levels was 98 %. Also, the proposed micro-extraction method exhibited results comparable with the solid phase extraction of real water samples. The proposed one-step VALLME and derivatization method is simpler and faster than the conventional extraction and derivatization methods used for the determination of DCF in real water samples

Comparison of Cad and Manual System Efficiency In Pre-Production Preparation Process

WOS: 000485289300008In the apparel industry, computer aided design (CAD) systems are most commonly used for basic pattern making, grading and marker making processes. Even though there are various software in this area in the market, pattern making process is still performed manually in several apparel businesses. In this research, the amount of time required for the processes of garment technical pattern making, modelling, grading and marker making via CAD systems was compared to time required for the manual method, with the aim of determining the more efficient approach. To this end, time measurements for the steps of these processes, specified by 3 expert pattern designers and 3 CAD operators, were taken and compared. The comparison was focused on the aspects of processes that made a difference in terms of time, the effect of these processes on total time and the identification of the factors that resulted in the time difference. Upper-body garments was chosen as the focus of this study due to the involvement of several steps in the processes of basic pattern making and grading. The acquired data shows that the process times required for CAD systems was shorter than that for manual design in every step that have an important role in the pre-production preparation process

Investigation of children victims of road traffic injuries required intensive care

Children are considered vulnerable road users (VRUs) in the literature, with high mortality and morbidity rates in accidents, resulting in various injuries such as head and neck injuries, fractures, tears, and post-traumatic stress disorder. The study was conducted retrospectively among patients admitted to the Pediatric Intensive Care Unit between October 1, 2017, and January 1, 2022, in a Hospital in Bursa. Eighty-six children were admitted to the study. Of them, 74.4% were male and 25.6% female. The average age was 8.8±5.0 years. The accidents occurred predominantly in urban areas (67.4%), with 32.6% occurring in rural areas. Pedestrians were 68.6% of the victims. Most accidents happened on Sundays (22.1%) and weekdays (62.8%). The distribution of accidents by season showed that most accidents occurred in the fall (29.1%), followed by spring (26.7%), summer (25.6%), and winter (18.6%). The most common time for accidents was between 18:00 and 00:00 (59.3%), and preschool-age children were most involved (44.2%). The most frequent type of injury was multiple trauma (50%), followed by isolated cranial trauma (29.1%). Of 14.0% victims died, and two became permanent care patients. The findings provide valuable insights for developing policies to prevent accidents and reduce associated morbidity and mortality. [Med-Science 2023; 12(4.000): 1284-9

A study on material selection of reusable surgical garments

WOS: 000335289900001Today, surgical garments are manufactured in two groups as disposable and reusable in the medical market. These garments prevent viruses from passing on to the patient and also keep medical staff from blood pathogens exposures. With modern technology it is possible to obtain surgical gowns and drapes by using many different materials. Therefore, in the selection of materials used in surgical gowns, purpose of clothing and surgical conditions must be considered. In this research, material structures of reusable scrub sets and reusable surgical gowns used in surgical operations are investigated and the relationships between specifications of surgical gowns and surgical scrub sets and air and water permeability values was evaluated by correlation analysis. Existing features of garments are compared with the specified properties of surgical garments according to the pr EN 13795 standard. As a result of the study, different types of material for surgical gown are proposed according to the types of surgery

A Case Of Erythema Multiforme Associated With Pustules: Coexistence Of Erythema Multiforme Minor And Acute Generalized Exanthamatous Pustulosis

Adverse cutaneous drug reactions (ACDRs) can mimic a variety of dermatologic diseases, causing confusion and additional work-up for differential diagnoses. In this report, a case who admitted with non-follicular pustules with extensive targetoid lesions during follow-up is presented. In this case, erythema multiforme (EM)-like lesions were predominant and pustules that were concordant with acute generalized exanthematous pustulosis were thought to be triggered after drug intake. ACDRs can mimic several different infectious and inflammatory entities, and they should be kept in mind in cases accompanied by EM-like lesions with pustules. To our knowledge, EM-like lesions with a small number of pustules are first described in the literature in this case report.WoSScopu