Effects of weight change on metachronous adenomatous polyps

BACKGROUND: Numerous epidemiologic studies have identified obesity as a vital risk factor for the development of colorectal cancer (CRC). More recently, obesity has been linked to the development of colorectal adenomatous polyps (adenomas), the precursor lesion of up to 80% of CRCs. The extent to which weight loss could reduce risk in obese patients is unclear. PROPOSED PROJECT: The proposed study is a randomized clinical trial that aims to evaluate the relationship between weight reduction and the prevalence of recurrent (metachronous) adenomas among obese patients in a safety-net health care setting. The intervention group will participate in a comprehensive, individually structured weight loss program in order to achieve successful long-term weight loss. The control group will receive no special recommendations about weight loss other than as part of “usual care”. Anthropometric measures (weight in kilograms [kg], height in meters squared [m2] and body mass index [BMI]) will be monitored annually until the time of surveillance colonoscopy which will occur in accordance with the U.S. Multi-Society Task Force recommendations. Statistical methods will be used to compare rates of recurrent adenomas among the two study groups after adjustments for duration of follow-up and potential confounders. CONCLUSION/SIGNIFICANCE: The results of this study will provide new evidence to support weight reduction as a preventive strategy for reducing CRC risk among obese patients

Remedies for Detainees: The Impact of the Ninth Circuit\u27s Decision on Medical Negligence Cases

This comment examines the impact of the Ninth Circuit‘s holding in medical neglect cases and whether the Second Circuit made an error. To examine this issue, it must first be understood what the factual and legal background is concerning each case, the detainee‘s medical rights and the types of actions they can bring against government employees. After examining the law, the Second Circuit‘s holding is then compared with the Ninth Circuit‘s holding. Finally, this comment argues why the Supreme Court should affirm the Ninth Circuit‘s holding

Remedies for Detainees: The Impact of the Ninth Circuit\u27s Decision on Medical Negligence Cases

This comment examines the impact of the Ninth Circuit‘s holding in medical neglect cases and whether the Second Circuit made an error. To examine this issue, it must first be understood what the factual and legal background is concerning each case, the detainee‘s medical rights and the types of actions they can bring against government employees. After examining the law, the Second Circuit‘s holding is then compared with the Ninth Circuit‘s holding. Finally, this comment argues why the Supreme Court should affirm the Ninth Circuit‘s holding

Redress: Rights and Other Remedies, A Comment on David Engel\u27s Article on Rights Consciousness

In responding to David Engel\u27s Article, this Comment analyzes how Engel situates contemporary perspectives on rights drawing from his research in Thailand. Engel shows how the discourse of rights carries with it meanings that have multiple and changing connotations and on the ground effects. Following on Engel\u27s questions about how consciousness of rights spreads and takes shape in local contexts, this Comment calls for expanding the substantive and methodological bases for understanding the changing effects of rights discourses. This Comment suggests that a study of the broader social and political implications, including the costs, of rights discourses (internationally, nationally, and locally) permits greater substantive awareness of the changing social and political landscapes. This can only be done with the kind of on-the-ground longitudinal study that Engel has conducted

SYNTHESIS OF HARD TO ACCESS BORYLATED COMPOUNDS AND A COMPUTATIONAL INVESTIGATION

Thesis (Ph.D.)--Michigan State University. Chemistry - Doctor of Philosophy, 2024This thesis outlines methods for accessing both C(sp2) and C(sp3) C-H bonds.C(Sp2)-B bonds are highly versatile and can be easily converted into C-C, C-N, and C-O bonds. Achieving selective access to para C-H bonds has been challenging due to the similar reactivity of meta and para bonds. This work introduces a method that creates an in-situ hydrogen-bonded steric shield to protect the ortho and meta positions, allowing access to the para C-H site. Furthermore, aryl Bpin compounds were demonstrated to undergo selective palladium-catalyzed Sarandeses-Sestelo coupling reactions with organoindium reagents. Additionally, a method for accessing sp3 C-H bonds is discussed. Borylating sp3 C-H bonds has traditionally been difficult and required large amounts of starting materials and reagents. This work presents an alternative strategy where sp2 C-H bonds are initially borylated using iridium catalysis, followed by hydrogenation using a bench stable catalyst to obtain saturated borylated compounds. Furthermore, this thesis includes a study investigating the mechanism of C-H borylation using a hydrazone ligand. Theoretical investigations were conducted to understand the mechanism of C- H borylation employing a hydrazone ligand.Description based on online resource. Title from PDF t.p. (Michigan State University Fedora Repository, viewed ).Includes bibliographical references

Redress: Rights and Other Remedies, A Comment on David Engel\u27s Article on Rights Consciousness

In responding to David Engel\u27s Article, this Comment analyzes how Engel situates contemporary perspectives on rights drawing from his research in Thailand. Engel shows how the discourse of rights carries with it meanings that have multiple and changing connotations and on the ground effects. Following on Engel\u27s questions about how consciousness of rights spreads and takes shape in local contexts, this Comment calls for expanding the substantive and methodological bases for understanding the changing effects of rights discourses. This Comment suggests that a study of the broader social and political implications, including the costs, of rights discourses (internationally, nationally, and locally) permits greater substantive awareness of the changing social and political landscapes. This can only be done with the kind of on-the-ground longitudinal study that Engel has conducted

ANTI- OBSESSIVE COMPULSIVE ACTIVITY OF HONEY

Objective: The present study aim to investigate the anti-obsessive compulsive disorder potential of honey in mice.Methods: The honey was given orally in two concentrations of 17.5 ml/kg and 35 ml/kg to mice for 21 days. The anti-obsessive compulsive activity was assessed on 21th day by in-vitro methods viz flickering-light induced obsessive- compulsive behaviour model developed in our laboratory (Patent No. 3087/DEL/2012) and marble-burying behaviour model. The biochemical estimation was also done on 21 days.Results: When honey was administered chronically for 21 days significantly reduced gnawing behaviour and marble-burying behaviour of mice. Interestingly in our biochemical estimations, both, brain serotonin and GABA level were significantly increased by honey. The anti-Obsessive compulsive activity of honey may be due to the presence of Tryptophan, which is an important precursor of serotonin in the serotonergic neurons thereby enhancing the biosynthesis of serotonin to facilitate the anti- obsessive compulsive activity.Conclusion: The present study revealed that honey possessed significant anti-OCD activity.Â