26 research outputs found
Schäume als neue Träger-Vehikel für die topische Applikation
Foams are relatively new delivery systems for topical administration. However, characterization of foams is only pooröy described in Pharmacopeias. A comprehensive approach to characterize foams has therefore been developed. Additionally, different formulation platforms were developed and investigated for their different release behaviour.Schäume sind relativ neue Freigabesysteme, deren Charakterisierung allerdings in den Arzneibüchern nur unzureichend beschrieben ist. Daher wurden Methoden entwickelt, um Schaumprodukte umfassend zu charakterisieren. Weiterhin wurde eine Formulierungsplattform entwickelt für Aerosol- und Non-Aerosolschäume und deren Einfluss auf die Wirkstofffreigabe untersucht
Bulk and surface rheology of Aculyn™ 22 and Aculyn™ 33 polymeric solutions and kinetics of foam drainage
This paper was accepted for publication in the journal Colloids and Surfaces A: Physicochemical and Engineering Aspects and the definitive published version is available at http://dx.doi.org/10.1016/j.colsurfa.2013.05.072Experimental investigations of both bulk and surface rheology of solutions of commercially available polymers AculynTM 22 and AculynTM 33 in presence of sodium chloride are performed in a wide range of the polymer and salt concentrations. It is shown that the bulk viscosity and the surface viscoelastic modulus of solutions of both polymers increases with the increase of polymer concentration and the decrease of the salt concentration. Solutions of both polymers demonstrate very good foamability and form stable foams. Foam drainage is governed mainly by the bulk viscosity when the latter is in the range of 100-500 mPa·s
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Responsive foams for nanoparticle delivery
We have developed responsive foam systems for nanoparticle delivery. The foams are easy to make, stable at room temperature, and can be engineered to break in response to temperature or moisture. Temperature-responsive foams are based on the phase transition of long chain alcohols and could be produced using medical grade nitrous oxide as a propellant. These temperature-sensitive foams could be used for polyacrylic acid (PAA)-based nanoparticle delivery. We also discuss moisture-responsive foams made with soap pump dispensers. Polyethylene glycol (PEG)-based nanoparticles or PMMA latex nanoparticles were loaded into Tween 20 foams and the particle size was not affected by the foam formulation or foam break. Using biocompatible detergents, we anticipate this will be a versatile and simple approach to producing foams for nanoparticle delivery with many potential pharmaceutical and personal care applications