BMI: Body Mass Index, error bars represent the standard error.

<p>BMI: Body Mass Index, error bars represent the standard error.</p

Adipose and lean tissue characteristics of participants.

<p>* Means (± SE) are adjusted for age and BMI,</p><p>† Means (± SE) are adjusted for age, sex and BMI,</p><p>|| Total fat area refers to: superficial + deep+visceral fat by MRI,</p><p>‡ p<0.05 comparing South Asians to Europeans overall,</p><p>§ p<0.05 comparing South Asian women to European women,</p><p>¶ p<0.05 comparing South Asian men to European men,</p><p>Note: There was no change in the IMCL change after adjustment for peak exercise capacity i.e. Vo2 max at 15 mins.</p

Baseline characteristics of participants.

<p>* Means (± SE) are adjusted for age,</p><p>† Means (± SE) are adjusted for age, sex, BMI ‡ p<0.05 comparing South Asians to Europeans overall,</p><p>§ p<0.05 comparing South Asian women to European women,</p><p>|| p<0.05 comparing South Asian men to European men; Physical activity score derived from the SHARE activity index (14).</p

HDL: High Density Lipoprotein, CRP: C-reactive protein.

<p>HDL: High Density Lipoprotein, CRP: C-reactive protein.</p

Kaplan-Meier survival analysis of men by SUA quartiles.

<p>P-values were calculated using logrank statistics.</p

Baseline characteristics in men and women stratified by SUA quartiles.

<p>Continuous variables are presented as means (SD). Abbreviations: Q1 = lowest quartile: males: <317 µmol/l, females: <280 µmol/l, Q2 = second quartile: males: 317–373 µmol/l, females: 280–336 µmol/l, Q3 = third quartile: males: 373–432 µmol/l, females: 336–395 µmol/l, Q4 = highest quartile males: >432 µmol/l, females: >395 µmol/l. BMI = body mass index. Diast. = diastolic.</p><p>P-values were obtained by analysis of variance for continuous variables and by Cochran-Armitage trend test for discrete variables.</p>*<p>HbA1c was only measured in diabetics.</p

Kaplan-Meier survival analysis of women by SUA quartiles.

<p>P-values were calculated using logrank statistics.</p

Hazard ratios and 95% confidence intervals for men and women calculated by Cox regression.

<p>Cut off points for quartiles: see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0059121#pone-0059121-t002" target="_blank">Table 2</a>. Ref = reference. Hazard ratios (95% confidence intervals). Primary outcome event = AMI, stroke, resuscitation after cardiac arrest or cardiovascular death.</p>*<p>Hazard ratios with p-values less than 0.05 are written in bold letters.</p><p>Model 1: uric acid.</p><p>Model 2: model 1+ age.</p><p>Model 3: model 2+ baseline serum creatinine and diuretics use.</p><p>Model 4: model 3+ baseline values of cholesterol, HDL-C, LDL-C, BMI, glucose, triglyceride, history of only diabetes/both diabetes and cardiovascular disease/only cardiovascular disease, history of congestive heart failure, systolic blood pressure, diastolic blood pressure, waist-hip ratio, tobacco use, alcohol use, beta-blocker use, statin use, aspirin use and sibutramine use.</p

Proportion of event-free men by SUA quartiles.

<p>P-values were calculated using logrank statistics.</p

Uric acid levels over time in patients with and without use of sibutramine.

<p>Uric acid levels over time in patients with and without use of sibutramine.</p