Bulk Level to Individual Particle Level Chemical Composition of Atmospheric Dust Aerosols (PM5) over a Semi-Arid Urban Zone of Western India (Rajasthan)

Mineral dust particles in the lower atmosphere may significantly influence radiative and optical budgets, along with the net chemical balance, through their interactions with ambient chemicals. Their ability to absotb/scatter incoming radiation strongly depends on their chemical composition (i.e., distribution of major crustal elements), but as yet there is no adequate regional database with regard to this for the Indian region. To create a regional database of background mineral dust from a semi-arid zone of western India, we measured the chemical composition of ambient particles (with aerodynamic diameter <= 5 mu m; PM5), collected from seven locations of Jaipur city (in the vicinity of Thar Desert; Rajasthan) at varying altitudes, during late-winter of 2012. The chemical compositions of the sampled particles at both bulk and individual levels were measured using X-ray fluorescence (XRF) and Scanning Electron Microscope equipped with Energy Dispersive X-ray (SEM-EDX) techniques, respectively. Significant differences in chemical compositions were observed among the seven sites, yet the bulk chemical compositions of the particles were broadly consistent with those of individual particles. Average elemental ratios of Mg/Al, Si/Al, K/Al, Ca/Al, Mn/Al, Fe/Al were found to be 0.44 +/- 0.22, 1.96 +/- 0.90, 0.65 +/- 0.22, 1.52 +/- 0.40, 0.84 and 1.54 +/- 1.67, respectively. We also estimated the complex refractive index (RIs at 550 nm wavelength) for the studied sites, yielding an average n and k (the real and imaginary parts of RI, respectively) of (1.56 +/- 0.03) + (6.5 +/- 4.6) x 10(-3)i, with the aerosols collected from Kukas Hill area (27.02 degrees N, 75.85 degrees E) having the highest iron (Fe) mass fraction (similar to 43%). Non-crustal elements e.g., Cu, S, C, Ag and Pb were found only in aerosols over the main city Birla Temple (Jaipur) at ground level (26.89 degrees N, 75.81 degrees E)

Morphology of Atmospheric Particles over Semi-Arid Region (Jaipur, Rajasthan) of India: Implications for Optical Properties

The regional dust morphology and spectral refractive indices (RIs; governed by hematite, Fe2O3 content at short wavelengths) are key elements for ascertaining direct radiative forcing of mineral dust aerosols. To provide morphological features of background mineral dust from a semi-arid zone in the vicinity of the Thar Desert, we carried out an expedition to the Jaipur city during late winter of 2012. Morphological analysis reveals the predominance of "Layered", "Angular" and "Flattened" particles, while the frequency distribution of a total of 235 dust particles shows the aspect ratio, AR and circularity parameter, CIR (measures of particle's non-sphericity) typically similar to 1.4 and similar to 0.8, respectively. Sensitivity analysis at 550 nm wavelength reveals the equivalent sphere model may underestimate Single Scattering Albedo, SSA for the dust with low (similar to 1.1%) hematite by similar to 3.5%. Both underestimation (by similar to 5.6%) and overestimation (up to 9.1%) are probable in case of dust with high hematite content (similar to 5.68%). In addition, the effect of AR on the dust scattering is significant in case of dust with high hematite content. More such regionally representative dust morphological data are required for better estimation of regional radiative forcing of mineral dust aerosols

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication

An annotated bird checklist of community-managed lands in Kailash Sacred Landscape-India, Kumaon Himalaya

In the Indian Himalayan region, community-managed lands such as community-managed forests and agriculture lands play an important role in conserving native biodiversity. Our avifaunal surveys done between 2013 and 2016 recorded 205 species belonging to 52 families. Two species were first records from Pithoragarh district. Six species are classified as Threatened and five as Near Threatened in the IUCN Red List. Six are Schedule-I species under the Indian Wildlife (Protection) Act, 1972. In total, 63 migratory (local/altitudinal and long-range) and 81 Himalayan endemic species were observed. Overall, our observations reveal a niche providing both transient and perennial havens for resident and migrant avifauna in our study site’s landscape. Our findings suggest that despite human persistence in the landscape, diversity within avifaunal guilds is rich in the community-managed lands. We recommend further research to focus on understanding the factors governing the bird distribution and co-occurrence in the landscape.

Occurrence and Composition of Fish Species in Three Different Locations of the Ganga River

The freshwater ecosystem's health and fish diversity depend on natural and human interventions. The present investigation was carried out for one year to observe the present physicochemical parameters, fish composition, and abundance with diversity at three selected locations, i.e., A1, A2, and A3. Physico-chemical parameters were exceptionally suitable, and the limnological conditions were favorable for the growth and survival of biodiversity. 39 fish species belonging to 8 orders and 16 families were recorded, and cypriniformes was the most predominant order, followed by siluriformes. Simpson's Diversity Index (D) at site A1 was D=0.73, site A2 D=0.82, and site A3 D=0.87. The highest diversity was found at site A3 and the lowest at site A1. The second most dominant catch of exotics in the landing has adversely impacted the Indian major carps. There should be proper regulations and guidelines for the production and disposal of effluents as well as excessive fishing of indigenous aquatic fisheries

Seasonal Variation, Diversity, and Composition of Planktons in the Ganga River

Plankton are important components of aquatic ecosystems because they contribute to primary production, which sustains fisheries and other ecosystem functions. The study was carried out over a one-year period at three Ganga River sites: Haridwar (Bhadrabad) site A1, Bijnor (Balawali) site A2, and Muzaffarnagar (Bairaj Ganga bridge) site. Bacillariphyceae made almost 65% of the phytoplankton at location A1 14% Chlorophyceae and 14% Cynophyceae. The zooplankton consisted of Protozoa (80%) and Cladocera (20%), with Ulvophyceae accounting for 7%. At location A2, the phytoplankton composition was Bacillariphyceae (79%) and Chlorophyceae (7%). ˃ Cynophyceae (7%). Ulvophyceae (7%), and zooplankton were Protozoa (80%), Rotifera (20%). At location A3, the phytoplankton mix shifted to Bacillariphyceae (70%). ˃ Chlorophyceae (18%) ˃ Cynophyceae (12%) and Protozoa (60%) Rotifera accounts for 40%. The Simpson diversity index (D) value for phytoplankton is 0.58, whereas for zooplankton, the value is 0.53. The mean plankton density at locations A1, A2, and A3 was 2059, 2959, and 3304 individuals per liter, respectively. Only dissolved oxygen in physicochemical characteristics correlated positively with plankton density; all other metrics correlated negatively

Impact assessment of integrated-pathy on cancer-related fatigue in cancer patients: an observational study

Abstract Background Integrated-pathy aims to integrate modern medicine with traditional systems via applying the holistic approach of Ayurveda, Yoga, and natural medicine. This is important for addressing the challenges surrounding the delivery of long-term palliative care for chronic ailments including cancer. The prime intent of this study was to substantiate the underlying hypothesis behind the differential and integrative approach having a positive impact on Quality of Life of cancer patients. Study design Cross-sectional Observational study. Methods A standardized questionnaire was developed and used, after obtaining written informed consent from patients to assess the impact of Integrated-pathy on patients (n = 103) diagnosed with cancer receiving care at Patanjali Yoggram. The research was carried out over 8 months. All participants received a uniform treatment protocol as prescribed by Patanjali. For the sample size determination and validation, α and 1-β was calculated and for the significance of the pre- and post-treatment QoL ratings, Shapiro wilk test and other descriptive statistics techniques were explored. Results A total of 103 patients seeking cancer special-healthcare were interviewed, out of which 39 (37.86%) remained finally based on the inclusion/exclusion criteria with age (25–65 years), types of cancers (Carcinoma and Sarcoma), chemotherapy/radiotherapy received or not, before opting Integrated-pathy. Follow-ups revealed a significant increase in the QoL (17.91%) after receiving the integrated therapy over a course of at least 1 month. Further, a significant reduction in cancer-related pain followed by an increase in QoL index was reported in the patients. Shapiro–wilk test revealed significant pairing (p < 0.001) with validation of the model using test. Conclusions To bolster evidence-based backing for Integrated-pathy, there is a need for clearly delineated clinical indicators that are measurable and trackable over time. Clinical investigators are encouraged to incorporate Integrated-pathy into their proposed interventions and conduct analogous studies to yield sustained advantages in the long run

A comprehensive analysis of the advances in Indian Digital Agricultural architecture

ICT-based interventions such as smart farming and precision agriculture are helping to improve the output of traditional agricultural systems and drive them toward sustainability. Data-driven technologies like remote sensing, smart sensors, and IoT-based devices constructed over AI/ML algorithms have become a fundamental aspect of agriculture that assists farmers with critical decision-making. This revolution is strengthening the farmers in terms of farm management by improving crop yield, pest control, soil health, etc. in real-time. We have thoroughly reviewed the digital adoption in terms of insights into the Indian agriculture sector and presented a comprehensive account of major ICT initiatives undertaken followed by a redundancy analysis as well as its influence on the sector. Unfortunately, while being a significant agrarian country, India's adoption of digital solutions is still in its infancy, as apparent from a close look at important FMIS and key components of recognized solutions used internationally. We found 28 FMIS solutions that are active globally, and have produced a list of 29 local (Indian) applications spread across 23 different agricultural sub-domains. Sadly, a majority among these were not unique and replicated similar features, besides just a few were found to be crop-specific applications. The article is unique in its approach to presenting the tale of digital penetration in the Indian agriculture sector and will be helpful to further Agri-stack vision of India

An In Vivo Evaluation of postoperative pain after root canal instrumentation using manual K-files and Kedo-S rotary files in primary molars

Aim: To determine postoperative pain after root canal instrumentation using manual K-file and rotary Kedo-S files in primary molars. Material and Method: Thirty-six primary mandibular molars from 4- to 8-year-old children requiring pulpectomy were randomly split into two groups of 18 teeth each, that is, manual file K-file (Group I) and Kedo-S rotary file (Group II). Children's pre- and postoperative pain was assessed using a four-point scale at different time intervals. Results: From the result of the present study, it was observed that the Kedo-S group showed significantly less pain after 24, 48, and 72 h. Conclusion: It was concluded from the present research that patients enrolled in the Kedo-s group experienced less pain