1,412 research outputs found

    TARGETED THERAPEUTIC DELIVERY: SUCCESS THROUGH MAGNETIC MICROCARRIERS

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    There has been keen interest in the development of a targeted therapeutic delivery system. Targeted therapeutic delivery system aims to target the therapeutics to the site of action. A number of targeted therapeutic delivery system has been studied for targeting of various drugs but researchers have shown keen interest in magnetic targeting now a day. These include magnetic microspheres, magnetic liposome, magnetic nanoparticles, magnetic resealed erythrocytes, magnetic emulsion etc. Magnetic microspheres involve applying an external magnetic field to capture drug-loaded magnetic carriers in a targeted site. Magnetic therapeutic targeting is a promising method to increase the delivery of therapeutic agents to tumor cells while reducing side effects.  Magnetic microspheres & molecular magnetic labels have been used for great number of application in various areas of biosciences, targeted drug delivery, diagnosis and in immunoassay. Much has been investigated and much more are to be investigated for the use of principle of magnetism in targeting of therapeutics to the various organs. Thus present review paper will discuss about mechanism of magnetic targeted therapeutics delivery, magnetic carriers, and application of magnetic microspheres in targeted delivery of therapeutics

    Pooling job physical exposure data from multiple independent studies in a consortium study of carpal tunnel syndrome

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    Pooling data from different epidemiological studies of musculoskeletal disorders (MSDs) is necessary to improve statistical power and to more precisely quantify exposure–response relationships for MSDs. The pooling process is difficult and time-consuming, and small methodological differences could lead to different exposure–response relationships. A subcommittee of a six-study research consortium studying carpal tunnel syndrome: (i) visited each study site, (ii) documented methods used to collect physical exposure data and (iii) determined compatibility of exposure variables across studies. Certain measures of force, frequency of exertion and duty cycle were collected by all studies and were largely compatible. A portion of studies had detailed data to investigate simultaneous combinations of force, frequency and duration of exertions. Limited compatibility was found for hand/wrist posture. Only two studies could calculate compatible Strain Index scores, but Threshold Limit Value for Hand Activity Level could be determined for all studies. Challenges of pooling data, resources required and recommendations for future researchers are discussed

    Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

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    The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum
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