1 research outputs found
Hybrid Nanostructures of Hyperbranched Polyester Loaded with Gd(III) and Dy(III) Ions
Hyperbranched polymers are successful
nanoscale functional platforms
for loading metal ions and creating promising nanomaterials for medicine.
This work presents the synthesis of metal–polymer nanostructures
based on a second generation hyperbranched polyester with eight terminal
benzoylthiocarbamate (BTC) groups loaded with Gd(III) or Dy(III) ions.
Their structure (Fourier transform infrared spectroscopy) and morphology
(transmission electron microscopy), photophysical (ultraviolet–visible
and luminescence spectroscopy), thermophysical, magnetic activity,
relaxivity, and aggregation properties (nanoparticle tracking analysis)
were studied. The formation of the metal–polymer complex is
carried out by chelation of lanthanide ions −CO and
−CS groups of the BTC fragment of polyester. Coordination
units with composition Ln(III)-3BTC (Ln = Dy, Gd) were localized on
the branched polymer platform. The load is three lanthanide ions per
branched polyester polybenzoylthiocarbamate macromolecule. Logarithms
of stability constants of complexes and composition of coordination
polyhedron have been determined. The dysprosium complex is in a paramagnetic
state with antiferromagnetic correlations, and the gadolinium complex
is in a paramagnetic state. The relaxivity of the Dy(III) and Gd(III)
complexes increased by 2.5 and 3 times, respectively, compared to
their nitrates. An important achievement is the identification of
rare-earth metal (REM)-controlled morphology and self-organization
for Dy(III) and Gd(III) complexes with branched polyester polybenzoylthiocarbamate
in solution and on the surface. Spherical nanostructures for the dysprosium
complex and nanorods for the gadolinium complex were observed. Synthesized
REM-loaded nanostructures with polyester polybenzoylthiocarbamates
have low hemotoxicity and can be applied in biomedicine