Reflecting on How Social Impacts are Considered in Transport Infrastructure Project Planning:Looking beyond the Claimed Success of Sydney’s South West Rail Link

Urban rail transport megaprojects are promoted as generating positive social change at a metropolitan scale, yet they produce complex unplanned negative impacts at local scales. Environmental and Social Impact Assessment (ESIA) and its follow-up help decision-makers assess and manage the social and environmental impacts of major projects. Using Western Sydney’s politically-successful South West Rail Link as an example, we identified the practice challenges and governance barriers to applying ESIA and EIA follow-up across spatial scales. These challenges and barriers influence the planning and management of the impacts of integrated urban development and transport infrastructure development

Metro infrastructure planning in Amsterdam:how are social issues managed in the absence of environmental and social impact assessment?

Amsterdam's North-South Metro Line (NZL) megaproject has had a long eventful history. From the initial proposal in the 1990s, through construction in the 2000s to 2010s, to its opening in 2018, the NZL overcame many challenges. Several geotechnical incidents in the Vijzelgracht neighbourhood in 2008 cost the City of Amsterdam and the Dutch government millions of Euros. These incidents required complex recovery management actions, and there was a complete re-evaluation of the project, resulting in extensive reformulation of the project's communications and impact management strategies, and in more-transparent public participation. Despite NZL's significance, it never underwent any formal Environmental and Social Impact Assessment (ESIA), thus it provides an interesting case to consider how social impacts are addressed when there is no formal ESIA. Drawing on document review, semi-structured interviews, and a focus group, we considered the experiences of key decision-makers and project team members to learn how social impacts were assessed and managed over time in the absence of ESIA. We conclude that, when combined with appropriate urban governance frameworks, applying ESIA in urban and transport planning would improve the assessment and management of the social impacts of future megaproject infrastructure developments

Assessing the Risk of SARS-CoV-2 Transmission via Surgical Electrocautery Plume

This quality improvement study used a nonhuman subject research approach to examine whether SARS-CoV-2 from aerosolized virus is present in and potentially transmissible from a electrocautery plume in surgery

A Cautionary Tale of European Disability Policies: Lessons for the United States

Variations in the size of the population receiving disability payments across countries cannot be explained by simple differences in health. Rather, the process to disability is shaped by both social and medical factors. When governments ignore this reality, a policy generated disability epidemic is possible. This paper compares disability policies in The Netherlands, Sweden, Germany, and the United States. It argues that the extraordinary increase in Dutch disability rolls in the 1970s was caused by a general government policy to reduce official unemployment. And that by the end of the 1980s, this policy had left Holland with a hidden unemployment rate that was twice its official rate and three times the unemployment rates in the United States and Germany

Economic openness and income growth : a reassessment of the relationship for developing countries

This study analyzes the economic growth differentials among developing countries across Sub-Saharan Africa (SSA), Latin America and the Caribbean (LAC), South and East Asia (SEA) and High Performing Asian Economies (HPAEs), in the context of economic openness. We also investigate economic growth differences between developing countries that opened up their economy early (1960s) and those that opened up later (1980s). The results, using the SYS-GMM estimator show that, economic openness as measured by foreign direct investment positively affects economic growth in SSA and HPAEs. In LAC and SEA, it has no effect on growth. Openness as measured by international trade positively affects growth in SSA and HPAEs. In SEA, the effect is mixed while in LAC, trade has no effect on growth. The HPAEs recorded higher positive trade effect on growth relative to the other countries on account of efficiently managed inflation and well developed human capital

Heterologous expression and secretion of nanobodies targeting Campylobacter jejuni for intestinal health applications

As strategies for engineering the enteric microflora continue to advance, the vision of a future with a secondary, artificial immune system increasingly comes into focus. There are numerous challenges that will need to be overcome before this is a reality including the construction of a chassis capable of producing functional antimicrobial compounds at adequate concentrations and the construction of libraries of antimicrobial compounds capable of targeting a range of pathogens including those that develop resistance. Towards these ends, I have elected to engineer Bacteroides thetaiotaomicron (B. theta), one of the most prevalent and stable organisms in the human distal gut, to heterologously express and secrete nanobodies that bind the flagella of Campylobacter jejuni. Nanobody genes were inserted behind native B. theta promoters and integrated into the genome allowing for induction following the introduction of a specific inducing compound. Signalling peptides were fused to the nanobodies allowing for targeting the nanobodies out of Escherichia coli (E. coli) cells. Also as part of this project, novel signal peptides have also been characterized allowing for the targeting of protein to any subcellular compartment within a gram-negative bacterium

Escape of HIV-1 from a Small Molecule CCR5 Inhibitor Is Not Associated with a Fitness Loss

Fitness is a parameter used to quantify how well an organism adapts to its environment; in the present study, fitness is a measure of how well strains of human immunodeficiency virus type 1 (HIV-1) replicate in tissue culture. When HIV-1 develops resistance in vitro or in vivo to antiretroviral drugs such as reverse transcriptase or protease inhibitors, its fitness is often impaired. Here, we have investigated whether the development of resistance in vitro to a small molecule CCR5 inhibitor, AD101, has an associated fitness cost. To do this, we developed a growth-competition assay involving dual infections with molecularly cloned viruses that are essentially isogenic outside the env genes under study. Real-time TaqMan quantitative PCR (QPCR) was used to quantify each competing virus individually via probes specific to different, phenotypically silent target sequences engineered within their vif genes. Head-to-head competition assays of env clones derived from the AD101 escape mutant isolate, the inhibitor-sensitive parental virus, and a passage control virus showed that AD101 resistance was not associated with a fitness loss. This observation is consistent with the retention of the resistant phenotype when the escape mutant was cultured for a total of 20 passages in the absence of the selecting compound. Amino acid substitutions in the V3 region of gp120 that confer complete AD101 resistance cause a fitness loss when introduced into an AD101-sensitive, parental clone; however, in the resistant isolate, changes elsewhere in env that occurred prior to the substitutions within V3 appear to compensate for the adverse effect of the V3 changes on replicative capacity. These in vitro studies may have implications for the development and management of resistance to other CCR5 inhibitors that are being evaluated clinically for the treatment of HIV-1 infection

IRMA calibrations and data analysis for telescope site selection

xii, 135 leaves : ill. ; 28 cm. --Our group has developed a 20 μm passive atmospheric water vapour monitor. The Infrared Radiometer for Millimetre Astronomy (IRMA) has been commissioned and deployed for site testing for the Thirty Meter Telescope (TMT) and the Giant Magellan Telescope (GMT). Measuring precipitable water vapour (PWV) requires both a sophisticated atmospheric model (BTRAM) and an instrument (IRMA). Atmospheric models depend on atmospheric profiles. Most profiles are generic in nature, representing only a latitude in some cases. Site-specific atmospheric profiles are required to accurately simulate the atmosphere above any location on Earth. These profiles can be created from publicly available archives of radiosonde data, that offer nearly global coverage. Having created a site-specific profile and model, it is necessary to determine the PWV sensitivity to the input parameter uncertainties used in the model. The instrument must also be properly calibrated. In this thesis, I describe the radiometric calibration of the IRMA instrument, and the creation and analysis of site-specific atmospheric models for use with the IRMA instrument in its capacity as an atmospheric water vapour monitor for site testing

Remote sensing of atmospheric water vapour above the Chilean Andes

xvii, 206 leaves : ill. (some col.) ; 28 cmWater vapour is the principle source of opacity at infrared wavelengths in the Earth’s atmosphere. In support of site testing for the European Extremely Large Telescope (E-ELT), we have used La Silla and Paranal as calibration sites to verify satellite measurements of precipitable water vapour (PWV). We reconstructed the PWV history over both sites by analysing thousands of archived high-resolution echelle calibration spectra and compared that to satellite estimates for the same period. Three PWV measurement campaigns were conducted over both sites using several independent measurement techniques. Radiosondes were launched to coincide with satellite measurements and provide a PWV reference standard allowing intercomparison between the various instruments and methods. This multi-faceted approach has resulted in a unique data set. Integral to this analysis is the internal consistency provided by using a common atmospheric model

Vitamin D deficiency and course of frailty in a depressed older population

Objective: To study the association between vitamin D levels and frailty, its components and course in a depressed sample. Methods: Baseline and two-year follow-up data from the depressed sample of the Netherlands Study of Depression in Older persons (NESDO), a prospective observational cohort study, were analyzed. The 378 participants (aged 60–93) had a diagnosis of depression according to DSM-IV criteria. Frailty was defined according to Fried’s physical phenotype. 25-OH vitamin D measurement was performed by liquid chromatography–tandem mass spectrometry. Linear and logistic regression analyses were performed, adjusted for covariates. Results: Higher vitamin D levels were cross-sectionally associated with lower prevalence of frailty (OR 0.64 [95%-CI 0.45–0.90], p =.010), predicted a lower incidence of frailty among non-frail depressed patients (OR 0.51 [95%-CI 0.26–1.00], p=.050), and, surprisingly, the persistence of frailty among frail depressed patients (OR 2.82 [95%-CI 1.23–6.49], p=.015). Conclusions: In a depressed population, higher vitamin D levels were associated with lower prevalence and incidence of frailty. Future studies should examine whether the favorable effect of low vitamin D levels on the course of frailty can be explained by confounding or whether unknown pathophysiological mechanisms may exert protective effects