317 research outputs found

    In Lyric Places

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    The Sea, its odors softly drifting, Drifting on the quiet air, Up the duns and over, floating, Floating down again till there..

    Descriptive Catalogue of the Art Collections of Bowdoin College

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    3d ed., rev. and enlhttps://digitalcommons.bowdoin.edu/art-museum-collection-catalogs/1002/thumbnail.jp

    Descriptive Catalogue of the Art Collections of Bowdoin College

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    3d ed., rev. and enlhttps://digitalcommons.bowdoin.edu/art-museum-miscellaneous-publications/1007/thumbnail.jp

    Descriptive Catalogue of the Bowdoin College Art Collections

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    Includes index.https://digitalcommons.bowdoin.edu/art-museum-collection-catalogs/1004/thumbnail.jp

    Catalogue of the Bowdoin College Art Collections: Part 1: The Bowdoin Drawings

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    Catalogue from the Bowdoin College Museum of Art.https://digitalcommons.bowdoin.edu/art-museum-collection-catalogs/1006/thumbnail.jp

    Letter from Providence School District Superintendent

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    Correspondence to Paul Sproll from the superintendent of Providence Schools, regarding schools\u27 performance and progress.https://digitalcommons.risd.edu/archives_tlad_poddocs/1007/thumbnail.jp

    Letter from Providence School District Superintendent

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    Correspondence to Paul Sproll from the superintendent of Providence Schools, regarding schools\u27 performance and progress.https://digitalcommons.risd.edu/archives_tlad_poddocs/1002/thumbnail.jp

    The Ursinus Weekly, April 26, 1965

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    Ursinus Meistersingers present tour program • Student-Faculty show combines music, humor, satire • Library week: April 25 to May 1 • Campus Chest encouraged by enthusiastic support: One down, one to go • Campus freedom, Sunisru and you • Dr. Helfferich hosts dinner • Invitation • Shakespeare theatre festival • Last chapel May 13th • Editorial: Meistersingers concert; They\u27re all right, Jack; In the name of sweet charity • H.R.C. wages unending war: Greater than 1776 • Toward maturity • Peon or pledge? • Lacrosse team remains undefeated • Baseball team evens log; Beats W. Maryland, Johns Hopkins • Thinclads nip Swarthmore • Softballers open season with win • MSGA candidates speak out: L. Rudnyansky; R. Reed; R. Shaw • U.C. student pioneer corpsman • Ruby sales awards • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1247/thumbnail.jp

    Equation of state of warm-dense boron nitride combining computation, modeling, and experiment

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    The equation of state (EOS) of materials at warm dense conditions poses significant challenges to both theory and experiment. We report a combined computational, modeling, and experimental investigation leveraging new theoretical and experimental capabilities to investigate warm-dense boron nitride (BN). The simulation methodologies include path integral Monte Carlo (PIMC), several density functional theory (DFT) molecular dynamics methods [plane-wave pseudopotential, Fermi operator expansion (FOE), and spectral quadrature (SQ)], activity expansion (ACTEX), and all-electron Green's function Korringa-Kohn-Rostoker (MECCA), and compute the pressure and internal energy of BN over a broad range of densities (ρ\rho) and temperatures (TT). Our experiments were conducted at the Omega laser facility and measured the Hugoniot of BN to unprecedented pressures (12--30 Mbar). The EOSs computed using different methods cross validate one another, and the experimental Hugoniot are in good agreement with our theoretical predictions. We assess that the largest discrepancies between theoretical predictions are <<4% in pressure and <<3% in energy and occur at 10610^6 K. We find remarkable consistency between the EOS from DFT calculations performed on different platforms and using different exchange-correlation functionals and those from PIMC using free-particle nodes. This provides strong evidence for the accuracy of both PIMC and DFT in the warm-dense regime. Moreover, SQ and FOE data have significantly smaller error bars than PIMC, and so represent significant advances for efficient computation at high TT. We also construct tabular EOS models and clarify the ionic and electronic structure of BN over a broad TρT-\rho range and quantify their roles in the EOS. The tabular models may be utilized for future simulations of laser-driven experiments that include BN as a candidate ablator material.Comment: 19 pages, 14 figures, 4 table

    Ivacaftor potentiation of multiple CFTR channels with gating mutations

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    AbstractBackgroundThe investigational CFTR potentiator ivacaftor (VX-770) increased CFTR channel activity and improved lung function in subjects with CF who have the G551D CFTR gating mutation. The aim of this in vitro study was to determine whether ivacaftor potentiates mutant CFTR with gating defects caused by other CFTR gating mutations.MethodsThe effects of ivacaftor on CFTR channel open probability and chloride transport were tested in electrophysiological studies using Fischer rat thyroid (FRT) cells expressing different CFTR gating mutations.ResultsIvacaftor potentiated multiple mutant CFTR forms with defects in CFTR channel gating. These included the G551D, G178R, S549N, S549R, G551S, G970R, G1244E, S1251N, S1255P and G1349D CFTR gating mutations.ConclusionThese in vitro data suggest that ivacaftor has a similar effect on all CFTR forms with gating defects and support investigation of the potential clinical benefit of ivacaftor in CF patients who have CFTR gating mutations beyond G551D
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