N-(4-Hydroxy­phen­yl)-2-(1,1,3-trioxo-2,3-di­hydro-1,2-benzothia­zol-2-yl)­acet­amide

In the title compound, C15H12N2O5S, the benzisothia­zole group is approximately planar (r.m.s. deviation excluding H atoms and the two O atoms bonded to S = 0.023 Å). The dihedral angle between the benzisothia­zole ring and the terminal phenol ring is 84.9 (1)°. In the crystal, mol­ecules are joined by N—H⋯O and O—H⋯O hydrogen bonds, and π-stacking inter­actions are observed between alternating phenol and benzisothia­zole rings [centroid–centroid distances = 3.929 (3) and 3.943 (3) Å]

Neoplastic growth of cerebral cavernous malformation presenting with impending cerebral herniation: A case report and review of the literature on de novo growth of cavernomas

Background: Cerebral cavernomas are rare vascular anomalies and their expansile growth has been considered to be mainly due to recurrent hemorrhages. They are not generally reported to show aggressive behavior.Case description: A 27-year-old male presented with headache, visual disturbances, and a 17-year history of seizures. He was known to have a temporal lobe lesion on CT scan, consistent with a diagnosis of cavernous malformation but with no relevant family history. Serial clinical and radiological follow-up revealed a progressive increase in the size of the lesion with formation of a growing cyst of 7 cm in diameter, which produced mass effect, resulting in the clinical picture of cerebral herniation. The patient underwent emergency surgical resection with symptomatic relief. There was no evidence of significant hemorrhage at surgery.Conclusion: Cavernous malformations can show expansile growth without any evidence of a presaging hemorrhagic event and, in the manner of a neoplastic lesion, present with raised intracranial pressure and cerebral herniation

Chance-type flexion-distraction fracture of lumbar spine

A case of a twenty years old male who had been hit by a van at the lower back, presented two weeks later with complete paraplegia and double incontinence is presented. Radiological imaging revealed shearing of spine with fracture line slicing through the second lumbar (L2) vertebra going across all the three vertebral columns with complete retrolisthesis of upper fragment. He was managed conservatively with immobilization and rehabilitation

Extradural granulocytic sarcoma causing acute paraparesis

A case of 9 years old female presenting with rapidly progressive paraparesis during remission phase of acute myeloblastic leukemia is reported. Radiological imaging revealed an extradural mass in the upper dorsal spine producing significant cord compression. The patient showed a dramatic neurological recovery after spinal cord decompression and subsequently treated with appropriate chemotherapy and local radiotherapy

Gas-producing brain abscess

A case of a known psychiatric patient who presented with rapid neurological deterioration is reported. Neuroimaging revealed a gas-producing brain abscess in left parietal lobe with a contiguous focus of infection in the adjacent bone and scalp initiated by obsessive scalp scratching. On complete surgical excision of abscess, followed by culture-based antibiotic therapy, a good neurological recovery was achieved with minimal residual deficits at follow-up

Isolated Sacral Metastasis Mimicking a Chordoma Presenting as a First Manifestation of Thyroid Malignancy: Case Report

Fifty-nine years old female presented with the clinical manifestations of lumbosacral plexopathy. MR imaging revealed a large destructive pelvic mass of sacral origin, mimicking a sacral chordoma. Histopathological findings are suggestive of follicular variant of papillary carcinoma of thyroid origin. There was no clinically palpable thyroid lesion or any clinical feature suggestive of thyroid dysfunction. This report describes an isolated sacral metastasis of thyroid origin without prior clinical features of thyroid malignancy. Keywords:  Sacral metastasis, Thyroid metastasis, sacral chordoma, spinal metastasis, sacral tumor, pelvic tumors

Mycoherbicidal potential of Alternaria alternata for management of Chenopodium album under field condition

A field experiment was conducted to evaluate the mycoherbicidal potential of Alternaria alternata to control Chenopodium album L., a problematic weed of wheat. Two wheat cultivars viz. Inqalab 91 and Punjab 96 were co-cultivated with C. album in 1:1 crop-weed ratio. Mycoherbicidal formulation was prepared in 20% canola oil emulsion with 107 conidia mL-1 of A. alternata. The mycoherbicidal formulation was sprayed at 2 - 3 and then at 4 - 5 leaf stage of the weed. Application of mycoherbicide significantly reduced the biomass of the target weed species up to 90%. Mycoherbicidal application significantly enhanced number of fertile tillers and 100 grains weight in both wheat cultivars. As a result of mycoherbicidal application, root and shoot biomass was significantly increased in cv. Inqalab 91 but not in cv. Punjab 96. The present study concludes that application of A. alternata in 20% canola oil can reduced growth of C. album resulting in enhanced growth and yield of wheat.Key words: Alternaria alternata, canola oil emulsion, Chenopodium album, mycoherbicide

Dielectric relaxation and infrared studies of hydrogen bonding

Dielectric relaxation and infrared study of a number of associating (H-bonding) compounds in glassy media, mainly polystyrene, have been carried out. The dielectric measurements by a General Radio 1621 Precision Capacitance bridge and infrared measurements by a Beckman spectrophotometer IR4250 have been described. The experimental dielectric data as a function of frequency at different temperatures were subjected to analysis by a series of computer programs written in APL and BASIC languages. The activation energy barriers opposing the dielectric relaxation processes were obtained by the application of the Eyring rate equation. An infrared study of various sterically hindered alcohols in polystyrene have been carried out. It is shown that a decrease in temperature leads to an increase in the degree of polymerization. The effect of steric factors on the degree of polymerization at a given temperature has also been discussed. Dielectric studies of sterically hindered alcohols, mainly in polystyrene matrix, have yielded, in some cases, completely separated molecular and intramolecular processes due to the H-bonded species. All alcohols gave a process owing to the H-bonded species with the exception of the most sterically hindered di-tert-butyl carbinol, tricyclohexyl carbinol and diphenyl methyl carbinol. The presence of Hbonded species was indentified by the infrared spectrum of the sample. In addition to sterically hindered alcohols, some simple small alcohols and water were also studied in a polystyrene matrix and in some other glassy media. The process owing to the H-bonded species was found to occur in the similar temperature region as was observed for sterically hindered alcohols. The energy barriers of the process related with H-bonded species for all the alcohols and water in a polystyrene were of a similar order of magnitude. A possible mechanism for the process related to H-bonded species was discussed. Dielectric studies on alcohol and amine systems in a polystyrene matrix have been carried out. It has been discussed that alcohols interact with amines, thus increase the dipole moment of the complexes which leads to an increase in the dielectric loss factor of the system. However, in many cases the dielectric process due to the complex, formed by alcoholamine interaction, was overlapped with the absorption owing to the H-bonded species of the alcohol and/or to the molecular process of amine

Primary chiasmal sarcoid granuloma masquerading as glioma of the optic chiasm

A 37-year-old woman presented with a 6 months history of headaches and memory impairment. Examination showed no neurological deficit with normal vision. MRI scans showed an enlarged optic chiasm. There was no dural or leptomeningeal enhancement or hydrocephalus. Open biopsy of the suprasellar mass showed non-caseating chronic granulomatous inflammation compatible with sarcoidosis. Systemic features of sarcoid were absent. Patient showed marked improvement on steroid therapy

Peritumoral cystic meningioma

A case of 39 years old male is described who presented with headache, right-sided focal fits and decreased power in the right hand. CT scan brain showed a left fronto-parietal cystic lesion with centrolateral intramural nodule with homogenous enhancement. At surgery, the extra-axial lesion with cyst containing xanthochromic fluid had a well-defined capsule that could easily be separated from the peri-lesional cortical surface. The dural-based nodule with its cyst wall was resected in toto. The histopathology of mural nodule was reported as meningioma while the cyst wall histology revealed meningothelial cells