Prevention of Chemotherapy-induced Peripheral Neuropathy with PRESIONA, a Therapeutic Exercise and Blood Flow Restriction Program: A Randomized Controlled Study Protocol

Objective This trial will analyze the acute and cumulative effects of a tailored program called PRESIONA that combines therapeutic exercise and blood flow restriction to prevent chemotherapy-induced peripheral neuropathy (CIPN) in individuals with early breast cancer undergoing neoadjuvant chemotherapy. Methods PRESIONA will be a physical therapist–led multimodal exercise program that uses blood flow restriction during low-load aerobic and strength exercises. For the acute study, only 1 session will be performed 1 day before the first taxane cycle, in which 72 women will be assessed before intervention and 24 hours post intervention. For the cumulative study, PRESIONA will consist of 24 to 36 sessions for 12 weeks following an undulatory prescription. At least 80 women will be randomized to the experimental group or control group. Feasibility will be quantified based on the participant recruitment to acceptance ratio; dropout, retention, and adherence rates; participant satisfaction; tolerance; and program security. In the efficacy study, the main outcomes will be CIPN symptoms assessed with a participant-reported questionnaire (EORTC QLQ-CIPN20). In addition, to determine the impact on other participant-reported health and sensorimotor and physical outcomes, the proportion of completed scheduled chemotherapy sessions will be examined at baseline (t0), after anthracycline completion (t1), after intervention (t2), and at the 2-month (t3) and 1-year follow-ups (t4). Conclusion The proposed innovative approach of this study could have a far-reaching impact on therapeutic options, and the physical therapist role could be essential in the oncology unit to improve quality of life in individuals with cancer and reduce side effects of cancer and its treatments. Impact Physical therapists in the health care system could be essential to achieve the planned doses of chemotherapy to improve survival and decrease the side effects of individuals with breast cancer. The prevention of CIPN would have an impact on the quality of life in these individuals, and this protocol potentially could provide an action guide that could be implemented in any health care system.This study is funded by Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (FI19/00230), the Spanish Ministry of Education Cultura y Deporte (FPU17/00939 and FPU18/03575), and Ilustre Colegio Profesional de Fisioterapeutas de Andalucía (AI-04/2020)

Design of a new cutting tool for drill bits

Traditional manufacturing techniques applied in the Mexican Mining Industry require a high number of experimental tests, long periods of machining time used, and high economic costs are generated. To solve this problem, it is proposed to use the computational simulation technique, which turns out to be a faster, low-cost, highly accurate, simple, and reliable technique to evaluate the performance of a cutting tool. In addition, with this technique, it is possible to simulate different geometries during the machining process, without generating economic losses and increasing the test accuracy. For this reason, the objective of this work was to design and validate a new cutting tool for the internal string of drill bits used in mining. The methodology used was through the implementation of the computational simulation technique and later the manufacture of the new tool. Which was mounted on a computerized numerical control lathe, and it was simultaneously introduced into the drill bit to perform the machining of the internal chord. To find the optimal geometry of such a tool, the finite element and design of experiment methods are used. Among the main results of this work is to identify the model that showed the best maximum effort performance, and that allows us to have a high safety factor. The deformation shown by the new cutting tool allows the manufactured parts to have adequate dimensional tolerances for their fit in the drill bit. The validation of the cutting tool design was carried out considering the cutting force that is generated in the machining process.Las técnicas tradicionales de manufactura en la Industria Minera Mexicana, requieren de un alto número de pruebas experimentales, utilizan largos periodos de tiempo de maquinado y generan altos costos económicos. Para resolver tal problemática, se propone utilizar la técnica de simulación computacional, la cual resulta ser una técnica más rápida, de bajo costo, de gran exactitud, sencilla y confiable para evaluar el desempeño de una herramienta de corte. Además, con esta técnica es posible simular diferentes geometrías durante el proceso de maquinado. Es por ello, que el objetivo del presente trabajo fue diseñar y validar una nueva herramienta de corte para la cuerda interna de brocas de perforación utilizadas en la minería. La metodología utilizada fue mediante la implementación de la técnica de simulación computacional y posteriormente la manufactura de la nueva herramienta. Posteriormente, fue necesario montar tal herramienta en un torno de control numérico computarizado, y simultáneamente introducirla al interior de la broca de perforación para realizar el maquinado de la cuerda interna. Para encontrar la geometría óptima de la herramienta se utilizan los métodos del elemento finito y de diseño de experimentos. Entre los principales resultados de este trabajo se encontró el determinar la geometría de la herramienta de corte que mostró el mejor desempeño de esfuerzo máximo, y que permite tener un factor de seguridad alto.La deformación que mostró la nueva herramienta de corte, permite que las piezas fabricadas tengan tolerancias dimensionales adecuadas para su ajuste en la broca de perforación. La validación del diseño de la herramienta de corte se realizó considerando la fuerza de corte que se genera en el proceso de maquinado