COVID-19 vaccine failure

COVID-19 affects the population unequally with a higher impact on aged and immunosuppressed people. Hence, we assessed the effect of SARS-CoV-2 vaccination in immune compromised patients (older adults and oncohematologic patients), compared with healthy counterparts. While the acquired humoral and cellular memory did not predict subsequent infection 18 months after full immunization, spectral and computational cytometry revealed several subsets within the CD8+ T-cells, B-cells, NK cells, monocytes and CD45RA+ CCR7- Tγδ cells differentially expressed in further infected and non-infected individuals not just following immunization, but also prior to that. Of note, up to 7 subsets were found within the CD45RA+ CCR7- Tγδ population with some of them being expanded and other decreased in subsequently infected individuals. Moreover, some of these subsets also predicted COVID-induced hospitalization in oncohematologic patients. Therefore, we hereby have identified several cellular subsets that, even before vaccination, strongly related to COVID-19 vulnerability as opposed to the acquisition of cellular and/or humoral memory following vaccination with SARS-CoV2 mRNA vaccines.This study has been funded through Programa Estratégico Instituto de Biología y Genética Molecular (IBGM Junta de Castilla y León. Ref. CCVC8485), Junta de Castilla y León (Proyectos COVID 07.04.467B04.74011.0) and the European Commission – NextGenerationEU (Regulation EU 2020/2094), through CSIC's Global Health Platform (PTI Salud Global; SGL21-03-026 and SGL2021-03-038)N

Diseño de herramientas de aprendizaje para estudiantes de los Grados de Veterinaria y Ciencias Agrarias y Bioeconomía, en la cría y mantenimiento de plancton para piscifactorías y acuarios

El objetivo principal de este proyecto ha sido aproximar a los estudiantes de Veterinaria a una realidad profesional concreta, la del mundo de la acuicultura y de los peces de acuario, que la mayoría no contempla como futura salida profesional, mediante el contacto con un sistema acuático real, la cría de Fito y Zooplancton, imprescindibles en acuicultura y acuariofilia. Paralelamente este mismo objetivo se hace extensible a los alumnos del grado de Ciencias Agrarias y Bioeconomía de la UPM.Se han cultivado las siguientes especies de: FITOPLANCTON: - Nannochloropsis gaditana - Phaeodactylum tricornutum - Athrospira máxima (Spirulina) y ZOOPLANCTON: - Brachionus plicatilis (Rotífero): - Tigriopus californicus (Copépodo) - Artemia salin