Acne resolution rates: Results of a single-blind, randomized, controlled, parallel phase III trial with EE/CMA (Belara (R)) and EE/LNG (Microgynon (R))

Background and Objective: Acne in women can often be successfully treated by the intake of oral contraceptives containing gestagens with anti-androgenic properties. This study aimed to evaluate the efficacy of the monophasic oral contraceptive ethinylestradiol/chlormadinone acetate (EE/CMA; Belara (R)) for the treatment of mild to moderate papulopustular acne of the face and acne-related disorders in comparison to EE/levonorgestrel (LNG; Microgynon (R)). Methods: 199 female acne patients were enrolled in a single-blind, randomized, multicentre phase III study and divided into two groups who received either EE/CMA or EE/LNG. The primary end point was fulfilled if the number of papules/pustules per half of the face present on admission had decreased by at least 50% in the 12th medication cycle. Results: 59.4% of the women under EE/CMA and 45.9% under EE/LNG were responders. The relative frequency of women with complete resolution was 16.5% under EE/CMA and 4.3% under EE/LNG at cycle 12. Conclusion: EE/CMA is an efficient treatment for women with mild and moderate papulopustular acne of the face and related disorders, reflecting the well-known anti-androgenic properties of the progestogen CMA. Copyright (C) 2001 S, Karger AG, Basel

Evidence for Intrinsic Redshifts in Normal Spiral Galaxies

The Tully-Fisher Relationship (TFR) is utilized to identify anomalous redshifts in normal spiral galaxies. Three redshift anomalies are identified in this analysis: (1) Several clusters of galaxies are examined in which late type spirals have significant excess redshifts relative to early type spirals in the same clusters, (2) Galaxies of morphology similar to ScI galaxies are found to have a systematic excess redshift relative to the redshifts expected if the Hubble Constant is 72 km s-1 Mpc-1, (3) individual galaxies, pairs, and groups are identified which strongly deviate from the predictions of a smooth Hubble flow. These redshift deviations are significantly larger than can be explained by peculiar motions and TFR errors. It is concluded that the redshift anomalies identified in this analysis are consistent with previous claims for large non-cosmological (intrinsic) redshifts.Comment: Accepted for publication at Astrophysics&Space Science. 36 pages including 8 tables and 7 figure

EMULATOR vs REAL PHONE: Android Malware Detection Using Machine Learning

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.The Android operating system has become the most popular operating system for smartphones and tablets leading to a rapid rise in malware. Sophisticated Android malware employ detection avoidance techniques in order to hide their malicious activities from analysis tools. These include a wide range of anti-emulator techniques, where the malware programs attempt to hide their malicious activities by detecting the emulator. For this reason, countermeasures against anti-emulation are becoming increasingly important in Android malware detection. Analysis and detection based on real devices can alleviate the problems of anti-emulation as well as improve the effectiveness of dynamic analysis. Hence, in this paper we present an investigation of machine learning based malware detection using dynamic analysis on real devices. A tool is implemented to automatically extract dynamic features from Android phones and through several experiments, a comparative analysis of emulator based vs. device based detection by means of several machine learning algorithms is undertaken. Our study shows that several features could be extracted more effectively from the on-device dynamic analysis compared to emulators. It was also found that approximately 24% more apps were successfully analysed on the phone. Furthermore, all of the studied machine learning based detection performed better when applied to features extracted from the on-device dynamic analysis

Massive Coronae of Galaxies

There is reason to suspect that about half of the baryons are in pressure-supported plasma in the halos of normal galaxies, drawn in by gravity along with about half of the dark matter. To be consistent with the observations this baryonic component, the corona, would have to be hotter than the kinetic temperature of the dark matter in the halo so as to produce acceptable central electron densities. We ascribe this hotter plasma temperature to the addition of entropy prior to and during assembly of the system, in an analogy to cluster formation. The plasma cooling time would be longer than the gravitational collapse time but, in the inner parts, shorter than the Hubble time, making the corona thermally unstable to the formation of a cloudy structure that may be in line with what is indicated by quasar absorption line systems. The corona of an isolated spiral galaxy would be a source of soft X-ray and recombination radiation, adding to the more commonly discussed effects of stars and supernovae. In this picture the mass in the corona is much larger than the mass in condensed baryons in a spiral galaxy. The corona thus would be a substantial reservoir of diffuse baryons that are settling and adding to the mass in interstellar matter and stars, so that star formation in isolated spirals will continue well beyond the present epoch.Comment: 14 pages, 5 figure

Further Evidence for Intrinsic Redshifts in Normal Spiral Galaxies

Evidence from galaxy absolute magnitudes, linear diameters, and HyperLeda images is presented which strongly supports the interpretation that some normal spiral galaxies can contain large non-cosmological (intrinsic) redshifts in excess of 5000 km s-1.Comment: 17 pages, Astrophysics&Space Science - Accepted for publicatio

Lopsided Galaxies, Weak Interactions and Boosting the Star Formation Rate

To investigate the link between weak tidal interactions in disk galaxies and the boosting of their recent star formation, we obtain images and spatially integrated spectra (3615A < lambda < 5315A) for 40 late-type spiral galaxies (Sab-Sbc) with varying degrees of lopsidedness (a dynamical indicator of weak interactions). We quantify lopsidedness as the amplitude of the m=1 Fourier component of the azimuthal surface brightness distribution, averaged over a range of radii. We compare the young stellar content, quantified by EW(H\delta_abs) and the strength of the 4000 Angstrom break (D_4000), with lopsidedness and find a 3-4 sigma correlation between the two. We also find a 3.2 sigma correlation between EW(H\beta_emission) and lopsidedness. Using the evolutionary population synthesis code of Bruzual & Charlot we model the spectra as an ``underlying population'' and a superimposed ``boost population'' with the aim of constraining the fractional boost in the SFR averaged over the past 0.5 Gyr (the characteristic lifetime of lopsidedness). From the difference in both EW(H\delta_abs) and D_4000 between the most and least symmetric thirds of our sample, we infer that ~ 1x10^9 M_solar of stars are formed over the duration of a lopsided event in addition to the ``underlying'' SFH (assuming a final galactic stellar mass of 10^10 M_solar). This corresponds to a factor of 8 increase in the SFR over the past 5x10^8 years. For the nuclear spectra, all of the above correlations except D_4000 vs. are weaker than for the disk, indicating that in lopsided galaxies, the SF boost is not dominated by the nucleus.Comment: 35 pages, including 10 figures, to appear in the Astrophysical Journal, abridged abstrac

Deflection of ultra high energy cosmic rays by the galactic magnetic field: from the sources to the detector

We report the results of 3D simulations of the trajectories of ultra-high energy protons and Fe nuclei (with energies $E = 4 \times 10^{19}$ and $2.5 \times 10^{20} eV$) propagating through the galactic magnetic field from the sources to the detector. A uniform distribution of anti-particles is backtracked from the detector, at the Earth, to the halo of the Galaxy. We assume an axisymmetric, large scale spiral magnetic field permeating both the disc and the halo. A normal field component to the galactic plane ($B_z$) is also included in part of the simulations. We find that the presence of a large scale galactic magnetic field does not generally affect the arrival directions of the protons, although the inclusion of a $B_z$ component may cause significant deflection of the lower energy protons ($E = 4 \times 10^{19}$ eV). Error boxes larger than or equal to $\sim 5^{\circ}$ are most expected in this case. On the other hand, in the case of heavy nuclei, the arrival direction of the particles is strongly dependent on the coordinates of the particle source. The deflection may be high enough ($> 20^{\circ}$) as to make extremely difficult any identification of the sources unless the real magnetic field configuration is accurately determined. Moreover, not every incoming particle direction is allowed between a given source and the detector. This generates sky patches which are virtually unobservable from the Earth. In the particular case of the UHE events of Yakutsk, Fly's Eye, and Akeno, they come from locations for which the deflection caused by the assumed magnetic field is not significant.Comment: LaTeX + 2 postscript figures - Color versions of both figures (highly recommended) available via anonymous ftp at ftp://capc07.ast.cam.ac.uk/pub/uhecr_gmf as fig*.g

Intrinsic Redshifts and the Tully-Fisher Distance Scale

The Tully-Fisher relationship (TFR) has been shown to have a relatively small observed scatter of ~ +/-0.35 mag implying an intrinsic scatter < +/-0.30 mag. However, when the TFR is calibrated from distances derived from the Hubble relation for field galaxies scatter is consistently found to be +/-0.64 to +/-0.84 mag. This significantly larger scatter requires that intrinsic TFR scatter is actually much larger than +/-0.30 mag, that field galaxies have an intrinsic TFR scatter much larger than cluster spirals, or that field galaxies have a velocity dispersion relative to the Hubble flow in excess of 1000 km s-1. Each of these potential explanations faces difficulties contradicted by available data and the results of previous studies. An alternative explanation is that the measured redshifts of galaxies are composed of a cosmological redshift component predicted from the value of the Hubble Constant and a superimposed intrinsic redshift component previously identified in other studies. This intrinsic redshift component may exceed 5000 km s-1 in individual galaxies. In this alternative scenario a possible value for the Hubble Constant is 55-60 km s-1 Mpc-1.Comment: 15 pages, Astrophysics&Space Science - Accepted for publicatio

The Distribution of Redshifts in New Samples of Quasi-stellar Objects

Two new samples of QSOs have been constructed from recent surveys to test the hypothesis that the redshift distribution of bright QSOs is periodic in $\log(1+z)$. The first of these comprises 57 different redshifts among all known close pairs or multiple QSOs, with image separations $\leq$ 10\arcsec, and the second consists of 39 QSOs selected through their X-ray emission and their proximity to bright comparatively nearby active galaxies. The redshift distributions of the samples are found to exhibit distinct peaks with a periodic separation of $\sim 0.089$ in $\log(1+z)$ identical to that claimed in earlier samples but now extended out to higher redshift peaks $z = 2.63, 3.45$ and 4.47, predicted by the formula but never seen before. The periodicity is also seen in a third sample, the 78 QSOs of the 3C and 3CR catalogues. It is present in these three datasets at an overall significance level $10^{-5}$ - $10^{-6}$, and appears not to be explicable by spectroscopic or similar selection effects. Possible interpretations are briefly discussed.Comment: submitted for publication in the Astronomical Journal, 15 figure

Globular Clusters as Candidates for Gravitational Lenses to Explain Quasar-Galaxy Associations

We argue that globular clusters (GCs) are good candidates for gravitational lenses in explaining quasar-galaxy associations. The catalog of associations (Bukhmastova 2001) compiled from the LEDA catalog of galaxies (Paturel 1997) and from the catalog of quasars (Veron-Cetty and Veron 1998) is used. Based on the new catalog containing 8382 pairs, we show that one might expect an increased number of GCs around irregular galaxies of types 9 and 10 from the hypothesis that distant compact sources are gravitationally lensed by GCs in the halos of foreground galaxies. The King model is used to determine the central surface densities of 135 GCs in the Milky Way. The distribution of GCs in central surface density was found to be lognormal.Comment: 22 pages, 4 figure